ID A0A2I3GVK5_NOMLE Unreviewed; 619 AA.
AC A0A2I3GVK5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Dystrophin {ECO:0000313|Ensembl:ENSNLEP00000035265.1};
GN Name=DMD {ECO:0000313|Ensembl:ENSNLEP00000035265.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000035265.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000035265.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000035265.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Anchors the extracellular matrix to the cytoskeleton via F-
CC actin. Ligand for dystroglycan. Component of the dystrophin-associated
CC glycoprotein complex which accumulates at the neuromuscular junction
CC (NMJ) and at a variety of synapses in the peripheral and central
CC nervous systems and has a structural function in stabilizing the
CC sarcolemma. Also implicated in signaling events and synaptic
CC transmission. {ECO:0000256|ARBA:ARBA00037032}.
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DR EMBL; ADFV01195228; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195229; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195231; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195233; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195235; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3GVK5; -.
DR Ensembl; ENSNLET00000038186.1; ENSNLEP00000035265.1; ENSNLEG00000010129.3.
DR GeneTree; ENSGT00940000154342; -.
DR Proteomes; UP000001073; Chromosome X.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd16246; EFh_DMD; 1.
DR CDD; cd02334; ZZ_dystrophin; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015153; EF-hand_dom_typ1.
DR InterPro; IPR015154; EF-hand_dom_typ2.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR12268:SF25; DYSTROPHIN; 1.
DR PANTHER; PTHR12268; E3 UBIQUITIN-PROTEIN LIGASE KCMF1; 1.
DR Pfam; PF09068; EF-hand_2; 1.
DR Pfam; PF09069; EF-hand_3; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 237..293
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT REGION 444..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 485..519
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 619 AA; 70432 MW; 912B890B09C2E4A8 CRC64;
RKKHLKTQTT CWDHPKMTEL YQSLADLNNV RFSAYRTAMK LRRLQKALCL DLLSLSAACD
ALDQHNLKQN DQPMDILQII NCLTTIYDRL EQEHNNLVNV PLCVDMCLNW LLNVYDTGRT
GRIRVLSFKT GIISLCKAHL EDKYRYLFKQ VASSTGFCDQ RRLGLLLHDS IQIPRQLGEV
ASFGGSNIEP SVRSCFQFAN NKPEIEAALF LDWMRLEPQS MVWLPVLHRV AAAETAKHQA
KCNICKECPI IGFRYRSLKH FNYDICQSCF FSGRVAKGHK MHYPMVEYCT PTTSGEDVRD
FAKVLKNKFR TKRYFAKHPR MGYLPVQTVL EGDNMETPAS SPQLSHDDTH SRIEHYASRL
AEMENSNGSY LNDSISPNES IDDEHLLIQH YCQSLNQDSP LSQPRSPAQI LISLESEERG
ELERILADLE EENRNLQAEY DRLKQQHEHK GLSPLPSPPE MMPTSPQSPR DAELIAEAKL
LRQHKGRLEA RMQILEDHNK QLESQLHRLR QLLEQPQAEA KVNGTTVSSP STSLQRSDSS
QPMLLRVVGS QTSDSMGEED LLSPPQDTST GLEEVMEQLN NSFPSSRGHN VGSLFHMADD
LGRAMESLVS VMTDEEGAE
//
