ID A0A2I3GWG8_NOMLE Unreviewed; 2585 AA.
AC A0A2I3GWG8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Teneurin transmembrane protein 3 {ECO:0000313|Ensembl:ENSNLEP00000035694.1};
GN Name=TENM3 {ECO:0000313|Ensembl:ENSNLEP00000035694.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000035694.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000035694.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000035694.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; ADFV01066016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01066017; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01066018; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01066019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01066020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01066021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01066022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01066023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01066024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01066025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000041044.1; ENSNLEP00000035694.1; ENSNLEG00000010584.2.
DR GeneTree; ENSGT01030000234566; -.
DR Proteomes; UP000001073; Chromosome 7b.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR NCBIfam; TIGR01643; YD_repeat_2x; 2.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF65; TENEURIN-3; 1.
DR Pfam; PF06484; Ten_N; 1.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 8.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..179
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 480..512
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 514..547
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 618..653
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 48..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 502..511
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 537..546
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 622..632
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 643..652
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2585 AA; 288880 MW; 88E39A3BDE61FE07 CRC64;
MQFLILIHLQ WIPKKLVVCI YIHIYVMSSL SFFFFFFFFS EQPANNQGQS TLQPLPPSHK
QHSAQHHPSI TSLNRNSLTN RRNQSPAPPA ALPAELQTTP ESVQLQDSWV LGSNVPLESR
HFLFKTGTGT TPLFSTATPG YTMASGSVYS PPTRPLPRNT LSRSAFKFKK SSKYCSWKCT
ALCAVGVSVL LAILLSYFIA MHLFGLNWQL QQTENDTFEN GKVNSDTMPT NTVSLPSGDN
GKLGGFMQEN NTIDSGELDI GRRAIQEVPP GIFWRSQLFI DQPQFLKFNI SLQKDALIGV
YGRKGLPPSH TQYDFVELLD GSRLIAREQR SLLETERAGR QARSVSLHEA GFIQYLDSGI
WHLAFYNDGK NAEQVSFNTI VIESVVECPR NCHGNGECVS GTCHCFPGFL GPDCSRAACP
VLCSGNGQYS KGRCLCFSGW KGTECDVPTT QCIDPQCGGR GICIMGSCAC NSGYKGENCE
EADCLDPGCS NHGVCIHGEC HCSPGWGGSN CEILKTMCPD QCSGHGTYLQ ESGSCTCDPN
WTGPDCSNEI CSVDCGSHGV CMGGTCRCEE GWTGPACNQR ACHPRCAEHG TCKDGKCECS
QGWNGEHCTI AHYLDKIVKE GCPGLCNSNG RCTLDQNGWH CVCQPGWRGA GCDVAMETLC
TDSKDNEGDG LIDCMDPDCC LQSSCQNQPY CRGLPDPQDI ISQSLQSPSQ QAAKSFYDRI
SFLIGSDSTH VIPGESPFNK SLASVIRGQV LTADGTPLIG VNVSFFHYPE YGYTITRQDG
MFDLVANGGA SLTLVFERSP FLTQYHTVWI PWNVFYVMDT LVMKKEENDI PSCDLSGFVR
PNPIIVSSPL STFFRSSPED SPIIPETQVL HEETTIPGTD LKLSYLSSRA AGYKSVLKIT
MTQSIIPFNL MKVHLMVAVV GRLFQKWFPA SPNLAYTFIW DKTDAYNQKV YGLSEAVVSV
GYEYESCLDL TLWEKRTAIL QGYELDASNM GGWTLDKHHV LDVQNGILYK GNGENQFISQ
QPPVVSSIMG NGRRRSISCP SCNGQADGNK LLAPVALACG IDGSLYVGDF NYVRRIFPSG
NVTSVLELRN KDFRHSSNPA HRYYLATDPV TGDLYVSDTN TRRIYRPKSL TGAKDLTKNA
EVIAGTGEQC LPFDEARCGD GGKAVEATLM SPKGMAVDKN GLIYFVDGTM IRKVDQNGII
STLLGSNDLT SARPLTCDTS MHISQVRLEW PTDLAINPMD NSIYVLDNNV VLQITENRQV
RIAAGRPMHC QVPGVEYPVG KHAVQTTLES ATAIAVSYSG VLYITETDEK KINRIRQVTT
DGEISLVAGI PSECDCKNDA NCDCYQSGDG YAKDARLNAP SSLAASPDGT LYIADLGNIR
IRAVSKNKPL LNSMNFYEVA SPTDQELYIF DINGTHQYTV SLVTGDYLYN FSYSNDNDIT
AVTDSNGNTL RIRRDPNRMP VRVVSPDNQV IWLTIGTNGC LKSMTAQGLE LVLFTYHGNS
GLLATKSDET GWTTFFDYDS EGRLTNVTFP TGVVTNLHGD MDKAITVDIE SSSREEDVSI
TSNLSSIDSF YTMVQDQLRN SYQIGYDGSL RIIYASGLDS HYQTEPHVLA GTANPTVAKR
NMTLPGENGQ NLVEWRFRKE QAQGKVNVFG RKLRVNGRNL LSVDFDRTTK TEKIYDDHRK
FLLRIAYDTS GHPTLWLPSS KLMAVNVTYS STGQIASIQR GTTSEKVDYD GQGRIVSRVF
ADGKTWSYTY LEKSMVLLLH SQRQYIFEYD MWDRLSAITM PSVARHTMQT IRSIGYYRNI
YNPPESNASI ITDYNEEGLL LQTAFLGTSR RVLFKYRRQT RLSEILYDST RVSFTYDETA
GVLKTVNLQS DGFICTIRYR QIGPLIDRQI FRFSEDGMVN ARFDYSYDNS FRVTSMQGVI
NETPLPIDLY QFDDISGKVE QFGKFGVIYY DINQIISTAV MTYTKHFDAH GRIKEIQYEI
FRSLMYWITI QYDNMGRVTK REIKIGPFAN TTKYAYEYDV DGQLQTVYLN EKIMWRYNYD
LNGNLHLLNP SNSARLTPLR YDLRDRITRL GDVQYRLDED GFLRQRGTEI FEYSSKGLLT
RVYSKGSGWT VIYRYDGLGR RVSSKTSLGQ HLQFFYADLT YPTRITHVYN HSSSEITSLY
YDLQGHLFAM EISSGDEFYI ASDNTGTPLA VFSSNGLMLK QIQYTAYGEI YFDSNIDFQL
VIGFHGGLYD PLTKLIHFGE RDYDILAGRW TTPDIEIWKR IGKDPAPFNL YMFRNNNPAS
KIHDVKDYVT DVNSWLVTFG FHLHNAIPGF PVPKFDLTEP SYELVKSQQW DDTPPIFGVQ
QQVARQAKAF LSLGKMAEVQ VSRRRAGGAK SWLWFATVKS LIGKGVMLAV SQGRVQTNVL
NIANEDCIKV AAVLNNAFYL ENLHFTIEGK DTHYFIKTTT PESDLGTLRL TSGRKALENG
INVTVSQSTT VVNGRTRRFA DVEMQFGALA LHVRYGMTLD EEKARILEQA RQRALARAWA
REQQRVRDGE EGARLWTEGE KRQLLSAGKV QGYDGYYVLS VEQYPELADS ANNIQFLRQS
EIGRR
//
