ID A0A2I3GWV5_NOMLE Unreviewed; 639 AA.
AC A0A2I3GWV5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Eosinophil peroxidase {ECO:0000313|Ensembl:ENSNLEP00000035722.1};
GN Name=EPX {ECO:0000313|Ensembl:ENSNLEP00000035722.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000035722.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000035722.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000035722.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
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DR EMBL; ADFV01070544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01070545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01070546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01070547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3GWV5; -.
DR STRING; 61853.ENSNLEP00000035722; -.
DR Ensembl; ENSNLET00000054690.1; ENSNLEP00000035722.1; ENSNLEG00000035172.1.
DR GeneTree; ENSGT00940000156009; -.
DR InParanoid; A0A2I3GWV5; -.
DR OMA; PRWNGDK; -.
DR Proteomes; UP000001073; Chromosome 14.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004601; F:peroxidase activity; IEA:Ensembl.
DR GO; GO:0002215; P:defense response to nematode; IEA:Ensembl.
DR GO; GO:0072677; P:eosinophil migration; IEA:Ensembl.
DR GO; GO:0032693; P:negative regulation of interleukin-10 production; IEA:Ensembl.
DR GO; GO:0032714; P:negative regulation of interleukin-5 production; IEA:Ensembl.
DR GO; GO:0010936; P:negative regulation of macrophage cytokine production; IEA:Ensembl.
DR GO; GO:0032753; P:positive regulation of interleukin-4 production; IEA:Ensembl.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 2.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR PANTHER; PTHR11475:SF63; EOSINOPHIL PEROXIDASE; 1.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR Pfam; PF03098; An_peroxidase; 2.
DR PRINTS; PR00457; ANPEROXIDASE.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
PE 4: Predicted;
KW Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..639
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014184078"
FT BINDING 398
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ SEQUENCE 639 AA; 71990 MW; DEEEEE4FE4644268 CRC64;
MYLLPALAGV LATLILAQPC EGTDPASPGA VETSVLRDCI AEAKLLVDAA YNWTQKSIKQ
RLRSGQPRAT RTVVRAADYM HVALGLLEEK LQPQRSGPFN VTDVLTEPQL LLLSQASGCA
LRDQAERCSN KYRTITGRCN NKRRPLLGAS NQALARWLPA EYEDGLSLPF GWTPGRRRNG
FLLPLVSWGQ FIDHDLDFSP ESPARVAFTA GVDCERTCDQ LPPCFPIKIP PNDPRIKNQR
DCIPFFRSAP SCPQNKNRVR NQINALTSFV DASMVYGSEV SLSLRLRNRT NYLGLLAINQ
RFQDNGRALL PFDNLHDDPC LLTNRSARIP CFLAGQTGRK VVSSQETAIS GIITYRDFLP
LVLGEARARR TLGPYRGYCS NVDPRVANVF TLAFRFGHTM LQPFMFRLDS QYQASAPNSH
VPLSSAFFAS WRIVYEGGID PILRGLMATP AKLNRQDAML VDELRDRLFR QVRRIGLDLA
ALNMQRSRDH GLPGYNAWRR FCGLSQPRNL AQLSRVLKNQ DLARKFLNLY GTPDNIDIWI
GAIAEPLLPG ARVGPLLACL FENQFRRARD GDRFWWQKRG VFTKRQRKAL RRISLSRIIC
DNTGITMVSR DIFRANIYPR GFVSCSRIPR LNLSAWRGT
//
