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Database: UniProt
Entry: A0A2I3GX59_NOMLE
LinkDB: A0A2I3GX59_NOMLE
Original site: A0A2I3GX59_NOMLE 
ID   A0A2I3GX59_NOMLE        Unreviewed;      4784 AA.
AC   A0A2I3GX59;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 5.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSNLEP00000035835};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSNLEP00000035835};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000035835, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000035835, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000035835}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; ADFV01037095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037097; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037098; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037100; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSNLET00000049302; ENSNLEP00000035835; ENSNLEG00000003602.
DR   GeneTree; ENSGT00940000154906; -.
DR   Proteomes; UP000001073; Chromosome 5.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 2.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4083   4109       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4130   4149       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4333   4353       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4407   4426       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4584   4606       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4661   4684       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       89    144       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      151    196       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      204    259       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      265    322       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      330    387       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      533    733       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      939   1136       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3880   3915       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     2939   2959       {ECO:0000256|SAM:Coils}.
FT   COILED     3204   3224       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4784 AA;  543268 MW;  0B8E4EBE16537E9E CRC64;
     DDEVVLQCTA TIHKEQQKLC LAAEGFGNRL CFLESTSNSK NVPPDLSICT FVLEQSLSVR
     ALQEMLANTM EKSEGQVDVE KWTAQGGGHR TLLYGHAILL RHSYSGMYLC CLSTSRSSTD
     KLAFDVGLQE DTTGEACWWT IHPASKQRSE GEKVRVGDDL ILVSVSSERY LHLSYGNGSL
     HVDAAFQQTL WSVAPISSGS EAAQGYLIGG DVLRLLHGHM DECLTVPSGE HGEEQRRTVH
     YEGGAVSVHA RSLWRLETLR VAWSGSHIRW GQPFRLRHVT TGKYLSLMED KNLLLMDKEK
     ADVKSTAFTF RSSKEKLDVG VRKEVDGMGT SEIKYGDSVC YIQHVDTGLW LTYQSVDVKS
     VRMGSIQRKA IMHHEGHMDD GISLSRSQHE ESRTARVIRS TVFLFNRFIR GLDALSKKAK
     AATVDLPIES VSLSLQDLIE VRVYQHSLLF CYRLHVYSSA AHFADVAGRE AGESWKSILN
     SLYELLAALI RGNRKNCAQF SGSLDWLISR LERLEASSGI LEVLHCVLVE SPEALNIIKE
     GHIKSIISLL DKHGRNHKVL DVLCSLCVCH GVAVRSNQHL ICDNLLPGRD LLLQTRLVNH
     VSSMRPIFFL GVSEVLNSLR VGWASTEGYS PYPGGGEEWG GNGVGDDLFS YGFDGLISGC
     IARTVSSPNQ HLLRTDDVIS CCLDLSAPSI SFRINGQPVQ GMFENFNIDG LFFPVVSFSA
     GIKVRFLLGG RHGEFKFLPP PGYAPCYEAV LPKEKLKVEH SREYKQERTY TRDLLGPTVS
     LTQAAFTPIP VDTSQIVLPP HLERIREKLA ENIHELWVMN KIELGWQYGP VRDDNKRQHP
     CLVEFSKLPE QERNYNLQMS LETLKDFYEK ANSIQISLSL IHSYQLTSGY KPAPMDLSFI
     KLTPSQEAMV DKLAENAHNV WARDRIRQGW TYGIQQDVKN RRNPRLVPYT LLDDRTKKSN
     KDSLREAVRT LLGYGYNLEA PDQDHAARAE VCSGTGERFR IFRAEKTYAV KAGRWYFEFE
     TVTAGDMRVG WSRPGCQPDQ ELGSDERAFA FDGFKAQRWH QGNEHYGRSW QAGDVVGCMV
     DMNEHTMMFT LNGEILLDDS GSELAFKDFD VGDGFIPVCS LGVAQVGRMN FGKDVSTLKY
     FTICGLQEGY EPFAVNTNRD ITMWLSKRLP QFLQVPSNHE HIEVTRIDGT IDSSPCLKVT
     QKSFGSQNSN TDIMFYRLSM PIECAEVFSK TVAGGLSGAG LFGPKNDLED YDADSDFEVL
     MKTAHGHLVP DRVDKDKEAT KPEFNNHKDY AQEKPSRLKQ RFLLRRTKPD YSTSHSARLT
     EDVLADDRDD YDFLMQTSTY YYSVRIFPGQ EPANVWVGWI TSDFHQYDTG FDLDRVRTVT
     VTLGDEKGKV HERLVFLNFF SKTPSQKNKN NQKKIFFLLS SFITNIIKFI CVFQVEPSTK
     LFPAVFAQAT SPNVFQFELG RIKNVMPLSA GLFKSEHKNP VPQCPPRLHV QFLSHVLWSR
     MPNQFLKVDV SRISERQGWL VQCLDPLQFM SLHIPEENRS VDILELTEQE ELLKFHYHTL
     RLYSAVCALG NHRVAHALCS HVDEPQLLYA IENKYMPGLL RAGYYDLLID IHLSSYATAR
     LMMNNEYIVP MTEETKSITL FPDENKKHGL PGIGLSTSLR PRMQFSSPSF VSISNECYQY
     SPEFPLDILK AKTIQMLTEA VKEGSLHARD PVGGTTEFLF VPLIKLFYTL LIMGIFHNED
     LKHILQLIEP SVFKEAATPE EESDTLEKEF SVDDAKLQGA GEEEAKGGKR PKEGLLQMKL
     PEPVKLQMCL LLQYLCDCQV RHRIEAIVAF SDDFVAKLQD NQRFRYNEVM QALNMSAALT
     ARKTKEFRSP PQEQINMLLN FKDDKSECPC PEEIRDQLLD FHEDLMTHCG IELDEDGSLD
     GNSDLTIRGR LLSLVEKVTY LKKKQAEKPV ESDSKKSSTL QQLISETMVR WAQESVIEDP
     ELVRAMFVLL HRQYDGIGGL VRALPKTYTI NGVSVEDTIN LLASLGQIRS LLSVRMGKEE
     EKLMIRGLGD IMNNKVFYQH PNLMRALGMH ETVMEVMVNV LGGGESKEIT FPKMVANCCR
     FLCYFCRISR QNQKAMFDHL SYLLENSSVG LASPAMRGST PLDVAAASVM DNNELALALR
     EPDLEKVVRY LAGCGLQSCQ MLVSKGYPDI GWNPSVEENA NVVVRLLIRR PECFGPALRG
     EGGNGLLAAM EEAIKIAEDP SRDGPSPNSG STKTLDTEEE EDDTIHMGNA IMTFYAALID
     LLGRCAPEMH LIHAGKGEAI RIRSILRSLI PLGDLVGVIS IAFQMPTIAK DGNVVEPDMS
     AGFCPDHKAA MVLFLDRVYG IEVQDFLLHL LEVGFLPDLR AAASLDTAAL SATDMALALN
     RYLCTAVLPL LTRCAPLFAG TEHHASLIDS LLHTVYRLSK GCSLTKAQRD SIEVCLLSIC
     GQLRPSMMQH LLRRLVFDVP LLNEHAKMPL KLLTNHYERC WKYYCLPGGW GNFGAASEEE
     LHLSRKLFWG IFDALSQKKY EQELFKLALP CLSAVAGALP PDYMESNYVS MMEKQSSMDS
     EGNFNPQPVD TSNITIPEKL EYFINKYAEH SHDKWSMDKL ANGWIYGEIY SDSSKVQPLM
     KPYKLLSEKE KEIYRWPIKE SLKTMLAWGW RIERTREGDS MALYNRTRRI SQTSQVSVDA
     AHGYSPRAID MSNVTLCRDL HAMAEMMAEN YHNIWAKKKK MELESKGGGN HPLLVPYDTL
     TAKEKAKDRE KAQDILKFLQ INGYAVSRGF KDLELDTPSI EKRFAYSFLQ QLIRYVDEAH
     QYILEFDGGS RGKGEHFPYE QEIKFFAKVV LPLIDQYFKN HRLYFLSAAS RPLCSGGHAS
     NKEKEMNIEK FSGQFIRHFV SSLGNDATSI VNCLHILGQT LDARTVMKTG LESVKSALRA
     FLDNAAEDLE KTMENLKQGQ FTHTRNQPKG VTQIINYTTV ALLPMLSSLF EHIGQHQFGE
     DLILEDVQVS CYRILTSLYA LGTSKSIYVE RQRSALGECL AAFAGAFPVA FLETHLDKHN
     IYSIYNTKSS RERAALSLPT NVEDVCPNIP SLEKLMEEIV ELAESGIRYT QMPHVMEVIL
     PMLCSYMSRW WEHGPENNPE RAEMCCTALN SEHMNTLLGN ILKIIYNNLG IDEGAWMKRL
     AVFSQPIINK VKPQLLKTHF LPLMEKLKKK AAMVVSEEDH LKAEARGDMS EAELLILDEF
     TTLARDLYKY LYPFLIILIY QINTYLCKNL QVLLVLTEIS FATSQNFKRE EQNFVVQNEI
     NNMSFLITDT KSKMSKAAVS DQERKKMKRK GDRYSMQTSL IVAALKRLLP IGLNICAPGD
     QELIALAKNR FSLKDTEDEV RDIIRSNIHL QGKLEDPAIR WQMALYKDLP NRTDDTSDPE
     KTVERVLDIA NVLFHLEQKS KRVGRRHYCL GSTVEHPQRS KKAVWHKLLS KQRKRAVVAC
     FRMAPLYNLP RHRAVNLFLQ GYEKSWIETE EHYFEDKLIE DLAKPGAEPP EEDEGTKRVD
     PLHQLILLFS RTTPSCHDEE DDDGEEEVKS FEEKEMEKQK LLYQQARLHD RGAAEMVLQT
     ISASKGETGP MVAATLKLGI AILNGGNSTV QQKMLDYLKE KKDVGFFQSL AGLMQSCSVL
     DLNAFERQNK AEGLGMVTEE GSGEKVLQDD EFTCDLFRFL QLLCEGHNSD FQNYLRTQTG
     NNTTVNIIIS TVDYLLRVQE SISDFYWYYS GKDVIDEQGQ RNFSKAIQVA KQVFNTLTEY
     IQGPCTGNQQ SLAHSRLWDA VVGFLHVFAH MQMKLSQDSS QIELLKELMD LQKDMVVMLL
     SMLEGNVVNG TIGKQMVDML VESSNNVEMI LKFFDMFLKL KDLTSSDTFK EYDPDGKGVI
     SKRDFHKAME SHKHYTQSET EFLLSCAETD ENETLDYEEF VKRFHEPAKD IGFNVAVLLT
     NLSEHMPNDT RLQTFLELAE SVLNYFQPFL GRIEIMGSAK RIERSSRTQW EKPQVKESKR
     QFIFDVVNEG GEKEKMELFV NFCEDTIFEM QLAAQISESD LNERSANKEE SEKERPEEQG
     PRMAFFSILT VKSALFALRY NILTLMRMLS LKSLKKQMKK VKKMTVKDMV TAFFSSYWSI
     FMTLLHFVAS VFRGFFRIVC SLLLGGSLVE GAKKIKVAEL LANMPDPTQD EVRGDGEEGE
     RKPLEAALPS EDLTDLKELT EESDLLSDIF GLDLKREGGQ YKLIPHNPNA GLSDLMITAA
     FSLDFGAYVL FICFHRGEDG EKEEKAKEDK GKQKLRQLHT HRYGEPEVPE SAFWKKIIAY
     QQKLLNYFAR NFYNMRMLAL FVAFAINFIL LFYKVSTSSV VEGKELPTRS SSENAKVTSL
     DSSSHRIIAV HYVLEESSGY MEPTLRILAI LHTVISFFCI IGYYCLKVPL VIFKREKEVA
     RKLEFDGLYI TEQPSEDDIK VNNYVRLSVM DKYGEFYGRD RISELLGMDK AALDFSDARE
     KKKPKKDSSL SAVLNSIDVK YQMWKLGVVF TDNVILPLPR LVYDYVCLGH YNNFFFAAHF
     LDIAMGFKTL RTILSSVTHN GKQLVLTVGL LAVVVYLYTV VAFNFFRKFY NKSEDGDTPD
     MKCDDMLTCY MFHMYVGVRA GGGIGDEIED PAGDEYEIYR IIFDITFFFF VIVILLAIIQ
     GLIIDAFGEL RDQQEQVKED METKCFICGI GNDYFDTVPH GFETHTLQEH NLANYLFFLM
     YLINKDETEH TGQESYVWKM YQERCWEFFP AGDCFRKQYE DQLN
//
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