ID A0A2I3GY67_NOMLE Unreviewed; 2123 AA.
AC A0A2I3GY67;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|RuleBase:RU364134};
GN Name=MED13 {ECO:0000313|Ensembl:ENSNLEP00000036304.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000036304.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000036304.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000036304.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex, which is composed of MED1,
CC MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L,
CC MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23,
CC MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and
CC CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
CC module termed the CDK8 module. Mediator containing the CDK8 module is
CC less active than Mediator lacking this module in supporting
CC transcriptional activation. Individual preparations of the Mediator
CC complex lacking one or more distinct subunits have been variously
CC termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
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DR EMBL; ADFV01107689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01107690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01107691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01107692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01107693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01107694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01107695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01107696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01107697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01107698; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000041739.1; ENSNLEP00000036304.1; ENSNLEG00000000545.3.
DR GeneTree; ENSGT00390000013680; -.
DR Proteomes; UP000001073; Chromosome 14.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF4; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 1360..1673
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1709..2112
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 428..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 780..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 954..1047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1434..1453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1506..1566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1964..1997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..466
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..724
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..762
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..995
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1047
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1506..1561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2123 AA; 233964 MW; A52766E50E555313 CRC64;
RFQVHSTCHC NPEDGADLTG IKWKKYVWQG PTSAPILFPV TEEDPILSSF SRCLKADVLG
VWRRDQRPGR RELWIFWWGE DPNFADLIHH DLSEEEDGVW ENGLSYECRT LLFKAVHNLL
ERCLMNRNFV RIGKWFVKPY EKDEKPINKS EHLSCSFTFF LHGDSNVCTS VEINQHQPVY
LLSEEHITLA QQSNSPFQVI LCPFGLNGTL TGQAFKMSDS ATKKLIGEWK QFYPISCCLK
EMSEEKQEDM DWEDDSLAAV EVLVAGVRMI YPACFVLVPQ SDIPTPSPVG STHCSSSCLG
VHQVPASTRD PAMSSVTLTP PTSPEEVQTV DPQSAQKWVK FSSVSDGFNS DSTSHHGGKI
PRKLANHVVD RVWQECNMNR AQNKRKYTAS SGGLCEEATA AKVASWDFVE ATQRTNCSCL
RHKNLKSRNA GQQGQAPSLG QQQQILPKHK TNEKQEKSEK PQKRPLTPFH HRVSVSDDVG
MDADSANQRL VMSAPDSQVR FSNIRTNDVA KTPQMHGTEM ANSPQPPPLS PHPCDVVDEG
VTKTPSTPQS QHFYQMPTPD PLVPSKPMED RIDSLSQSFP PQYQEAVEPT VYVGTAVNLE
EDEANIAWKY YKVPKKKDVE FLPPQLPSDK FKDDPVGPFG QESVTSVTEL MVQCKKPLKV
SDELVQQYQI KNQYLSAIAS DAEQEPKIDP YAFVEGDEEF LFPDKKDRQN SEREAGKKHK
VEDGTSSVTV LSHEEDAMSL FSPSVKQDAP RPTSHARPPS TSLIYDSDLA VSYTDLDNLF
NSDEDELTPG SKKSANGSDD KASCKESKTG NLDPLSCIST ADLHKMYPTP PSLEQHIMGF
SPMNMNNKEY GSMDTTPGGT VLEGNSSSIG AQFKIEVDEG FCSPKPSEIK DFSYVYKPEN
CQILVGCSMF APLKTLPSQY LPPIKLPEEC IYRQSWTVGK LELLSSGPAM PFIKEGDGSN
MDQEYGPAYT PQTHTSFGMP PSSAPPSNSG AGILPSPSTP RFPTPRTPRT PRTPRGAGGP
ASAQGSVKYE NSDLYSPAST PSTCRPLNSV EPATVPSIPE AHSLYVNLIL SESVMNLFKD
CNFDSCCICV CNMNIKGADV GVYIPDPTQE AQYRCTCGFS AVMNRKFGNN SGLFLEDELD
IIGRNTDCGK EAEKRFEALR ATSAEHVNGG LKESEKLSDD LILLLQDQCT NLFSPFGAAD
QDPFPKSGVI SNWVRVEERD CCNDCYLALE HGRQFMDNMS GGKVDEALVK SSCLHPWSKR
NDVSMQCSQD ILRMLLSLQP VLQDAIQKKR TVRPWGVQGP LTWQQFHKMA GRGSYGTDES
PEPLPIPTFL LGYDYDYLVL SPFALPYWER LMLEPYGSQR DIAYVVLCPE NEALLNGAKS
FFRDLTAIYE CLGENRKQVI KFPTCFYSLG PYLASLPLDS SLLSQPNLVA PTSQSLITPP
QMTNTGNANT PSATLASAAS STMTMTSGVA ISTSVATANS TLTTASTSSS SSSNLNSGVS
SNKLPSFPPF GSMNSNAAGS MSTQANTVQS GQLGGQQTSA LQTAGISGES SSLPTQPHPD
VSESTMDRDK VGIPTDGDSH AITYPPAIVV YIIDPFTYEN TDESTNSSSV WTLGLLRCFL
EMVQTLPPHI KSTVSVQIIP CQYLLQPVKH EDREIYPQHL KSLAFSAFTQ CRRPLPTSTN
VKTLTGFGPG LAMETALRSP DRPECIRLYA PPFILAPVKD KQTELGETFG EAGQKYNVLF
VGYCLSHDQR WILASCTDLY GELLETCIIN IDVPNRARRK KSSARKFGLQ KLWEWCLGLV
QMSSLPWRVV IGRLGRIGHG ELKDWSCLLS RRNLQSLSKR LKDMCRMCGI SAADSPSILS
ACLVAMEPQG SFVIMPDSVS TGSVFGRSTT LNMQTSQLNT PQDTSCTHIL VFPTSASVQV
ASATYTTENL DLAFNPNNDG ADGMGIFDLL DTGDDLDPDI INILPASPTG SPVHSPGSHY
PHGGDAGKGQ STDRLLSTEP HEEVPNILQQ PLALGYFVST AKAGPLPDWF WSACPQAQYQ
CPLFLKASLH LHVPSVQSDE LLHSKHSHPL DSNQTSDVLR FVLEQYNALS WLTCDPAIQD
RRSCLPIHFV VLNQLYNFIM NML
//
