ID A0A2I3GYP0_NOMLE Unreviewed; 958 AA.
AC A0A2I3GYP0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Rho guanine nucleotide exchange factor 2 {ECO:0000256|ARBA:ARBA00017262};
DE AltName: Full=Guanine nucleotide exchange factor H1 {ECO:0000256|ARBA:ARBA00031760};
GN Name=ARHGEF2 {ECO:0000313|Ensembl:ENSNLEP00000036396.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000036396.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000036396.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000036396.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}. Cytoplasmic vesicle
CC {ECO:0000256|ARBA:ARBA00004541}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01183692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01183693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01183694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01183695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01183696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01183697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01183698; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01183699; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01183700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01183701; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3GYP0; -.
DR Ensembl; ENSNLET00000039791.1; ENSNLEP00000036396.1; ENSNLEG00000012264.3.
DR GeneTree; ENSGT00940000158341; -.
DR Proteomes; UP000001073; Chromosome 12.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd20877; C1_ARHGEF2; 1.
DR CDD; cd13393; PH_ARHGEF2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037806; ARHGEF2_PH.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR13944; AGAP007712-PA; 1.
DR PANTHER; PTHR13944:SF20; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 12..59
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 207..404
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 444..543
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 655..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..921
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..958
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 958 AA; 108500 MW; 34A432CB43ECA6DC CRC64;
MKEAKDARYT NGHLFTTISV SGMTMCYACN KSITAKEALI CPTCNVTIHN RCKDTLANCT
KVKQKQQKAA LLKNNTALQS VSLRSKTTIR ERPSSAIYPS DSFRQSLLGS RRGRSSLSLA
KSVSTTNIAG HFNDESPLGL RRILSQSTDS LNMRNRTLSV ESLIDEEVIY NELMSDFEMD
EKDFAADSWS LAVDSSFLQQ HKKEVMKQQD VIYELIQTEL HHVRTLKIMT RLFRTGMLEE
LQLEPGVVQG LFPCVDELSD IHTRFLSQLL ERRRQALCPG STRNFVIHRL GDLLISQFSG
PSAEQMRKTY SEFCSRHTKA LKLYKELYAR DKRFQQFIRK VTRSAVLKRH GVQECILLVT
QRITKYPVLL SRILQHSHGI EEERQDLTTA LGLVKELLSN VDQDIYELEK GARLQEIYNR
MDPRAQTPVP GKGPFGREEL LRRKLIHDGC LLWKTATGRF KDVLMLLMTD VLLFLQEKDQ
KYIFPTLDKP SVVSLQNLIV RDIANQEKGM FLISAAPPEM YEVHTASRDD RSTWIRVIQQ
SVRICPSRED FPLIETEDEA YLRRIKMELQ QKDRALVELL REKVGLFAEM THFQAEEDGG
SGMALPTLPR GLFRSESLES PRGERLLQDA IREVEGLKDL LVGPGVELLL TPREPALPLE
PDSGGNTSPG VTANGEARTF NGSIELCRAD SDSSQRDRNG NQLRSPQEEA LQRLVNLYGL
LHGLQAAVAQ QDTLMEARFP EGPEWREKLC RANSRDGEAG RAGAAPVVPE KQATELALLQ
RQHALLQEEL RRCRRLGEER ATEAGSLEAR LRESEQARAL LEREAEEARR QLAALGQTEP
LPAEAPWARR PVDPRRRSLP AGDALYLSFN PPQPSRGTDR LDLPVTTRSV HRHFEDRERQ
ELGSPEERLQ DSSDPDTGSE EEGSSRLSPP HSPRDFTRMQ DIPEETESRD GEAVASES
//
