ID A0A2I3GZK2_NOMLE Unreviewed; 329 AA.
AC A0A2I3GZK2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Ku domain-containing protein {ECO:0000259|SMART:SM00559};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000036685.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000036685.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000036685.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ku70 family.
CC {ECO:0000256|ARBA:ARBA00005240}.
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DR EMBL; ADFV01114908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01114909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3GZK2; -.
DR STRING; 61853.ENSNLEP00000036685; -.
DR Ensembl; ENSNLET00000047535.1; ENSNLEP00000036685.1; ENSNLEG00000034323.1.
DR GeneTree; ENSGT00940000153239; -.
DR InParanoid; A0A2I3GZK2; -.
DR OMA; NRCLAND; -.
DR Proteomes; UP000001073; Chromosome 3.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0010558; P:negative regulation of macromolecule biosynthetic process; IEA:UniProt.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd00788; KU70; 1.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 4.10.970.10; Ku70, bridge and pillars; 1.
DR InterPro; IPR006165; Ku70.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR027388; Ku70_bridge/pillars_dom_sf.
DR InterPro; IPR047087; KU70_core_dom.
DR InterPro; IPR005160; Ku_C.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR NCBIfam; TIGR00578; ku70; 1.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF7; KU DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03730; Ku_C; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 87..233
FT /note="Ku"
FT /evidence="ECO:0000259|SMART:SM00559"
FT REGION 300..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..329
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 329 AA; 37939 MW; CCD920CC74167469 CRC64;
TDLTTRSVKV RFEESSKLED LLQKLCAKEI RKQALSRLKL KLNKDIVISV GICSLVQKAL
KPPPIKLHQE TNELVKTKTL TFNTNTCSLL LPSDTKRSQI CGSHQIIPEK EEPEELKWFN
DPGLMLMGFK PLLMLKKHHY LRPSLFVYPE ESLMIGSSIL FSTLLIKCLE KEVIALCRFT
PHRNIPPYFV ALVPQEEELD DQKIQVTPPG FQLVFLPFTD DKMKMRFTEK VKVMATPEQM
DKMKAIIQKL CFIYRSDSFE NPVLQQHFLN LDALVEAMNK RLGSLVDEFK ELVYLPDYNP
EGKVTKRKHD NEASGSKRPK MESIHKQPA
//
