GenomeNet

Database: UniProt
Entry: A0A2I3H0N9_NOMLE
LinkDB: A0A2I3H0N9_NOMLE
Original site: A0A2I3H0N9_NOMLE 
ID   A0A2I3H0N9_NOMLE        Unreviewed;      4415 AA.
AC   A0A2I3H0N9;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 6.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSNLEP00000037111};
GN   Name=RYR1 {ECO:0000313|Ensembl:ENSNLEP00000037111};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000037111, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000037111, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000037111}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; ADFV01001693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01001694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01001695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01001696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01001697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01001698; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01001699; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01001700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01001701; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01001702; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSNLET00000054449; ENSNLEP00000037111; ENSNLEG00000034556.
DR   GeneTree; ENSGT00940000155288; -.
DR   Proteomes; UP000001073; Chromosome 11.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0031674; C:I band; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030314; C:junctional membrane complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0006936; P:muscle contraction; IEA:Ensembl.
DR   GO; GO:0043931; P:ossification involved in bone maturation; IEA:Ensembl.
DR   GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 9.
DR   PANTHER; PTHR13715:SF15; PTHR13715:SF15; 9.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 2.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 2.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3780   3802       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3993   4013       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4081   4104       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4296   4319       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       97    152       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      159    204       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    264       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    327       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      335    392       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      565    777       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1727   1754       {ECO:0000256|SAM:Coils}.
FT   COILED     2465   2485       {ECO:0000256|SAM:Coils}.
FT   COILED     3189   3209       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4415 AA;  492796 MW;  2449BA8417B1536A CRC64;
     MGDAEGEDEV QFLRTDDEVV LQCSATVLKE QLKLCLAAEG FGNRLCFLEP TSNAQNVPPD
     LAICCFVLEQ SLSVRALQEM LANTVEAGVE VRTPPGGGTL QYGHAILLRH AHSRMYMSCL
     TTSRSMTDKL AFDVGLQEDA TGEACWWTMH PASKQRSEGE KVRVGDDIIL VSVSSERYLH
     LSTASGELQV DASFMQTLWN MNPICSRCEE GFVTGGHVLR LFHGHMDECL TISPADSDDQ
     RRLVYYEGGA VCTHARSLWR LEPLRISWSG SHLRWGQPLR VRHVTTGRYL ALTEDQGLVV
     VDASKAHTKA TSFCFRISKE KLDVAPKRDV EGMGPPEIKY GESLCFVQHV ASGLWLTYAA
     PDPKALRLGV LKKKAMLHQE GHMDDALSLT RCQQEESQAA RMIHSTNGLY NQFIKSLDSF
     SGKPRGSGPP AGTALPIEGV ILSLQDLIIY FEPPSEDLQH EEKQSKLRSL RNRQSLFQEE
     GMLSLVLNCI DRLNVYTTAA HFAEFAGEEA AESWKEIVNL LYELLGRGPS PDSPKNTPDP
     HKLDRLEASS GILEVLYCVL IESPEVLNII QENHIKSIIS LLDKHGRNHK VLDVLCSLCV
     CNGVAVRSNQ DLITENLLPG RELLLQTNLI NYVTSIRPNI FVGRVMVDEV TPFLTAQATH
     LRVGWALTEG YSPYPGGGEG WGGNGVGDDL YSYGFDGLHL WTGHVARPVT SPGQHLLAPE
     DVVSCCLDLS VPSISFRING CPVQGVFESF NLDGLFFPVV SFSAGVKVRF LLGGRHGEFK
     FLPPPGYAPC HEAVLPRERL HLEPIKEYRR EGPRGPHLVG PSRCLSHIDF VPCPVDTVQI
     VLPPHLERIR EKLAENIHEL WALTRIEQGW TYGPVRDDNK RLHPCLVDFH SLPEPERNYN
     LQMSGETLKT LLALGCHVGM ADEKAEDNLK KTKLPKTYMM SNGYKPAPLD LSHVRLTPAQ
     TTLVDRLAEN GHNVWARDRV GQGWSYSAVQ DIPARRNPRL VPYRLLDEAT KRSNRDSLCQ
     AVRTLLGYGY NIEPPDQEPS QVENQSRCDR VRIFRAEKSY AVQSGRWYFE FEAVTTGEMR
     VGWARPELRP DVELGADELA YVFNGHRVGT SLGNILPGPV VSPTQNPVST QNKQNYLGVE
     PMAWPSLLPS SVLYSLPPQV SRVDGTVDTP PCLRLTHRTW GSQNSLVEMV FLRLSLPVQF
     HQHFRCTAGA TPLAPPGLQP PAEDEARAAE PDPDYENLRR SAGGWGEAEN GKEGTAKEGA
     PGGTPQAGGE VQPVRAENEK DATTEKNKKR GFLFKAKKVA MMTQPPATPT LPRLPHDVVP
     ADNRDDPEII LNTTTVWTRN PQFWVPSNCP PYTGDSPCSN CYMVWGGDFV SPGQQGRISH
     TDLVIGCLVD LATGLMTFTA NGKESNTFFQ VEPNTKLFPA VFVLPTHQNV IQFELGKQKN
     IMPLSAAMFQ SERKNPAPQC PPRLEMQMLM PVSWSRMPNH YLQVETRRAG ERLGWAVQCQ
     EPLTMMALHI PEEKRCMDIL ELSERLDLQR FHSHTLRLYR AVCALGNNRV AHALCSHVDQ
     AQLLHALEDA HLPGPLRAGY YDLLISIHLE SACRSRRSML SEYIVPLTPE TRAITLFPPG
     RSTENGHPRH GLPGVGVTTS LRPPHHFSPP CFVAALPAAG ATEAPARLSP AIPLEALRDK
     ALRMLGEAVR DGGQHARDPV GGSVEFQFVP VLKLVSTLLV MASSCFRGTA QEKEDEAKEE
     EEAAEGEKEE GLEEGLLQMK LPESVKLQMC HLLEYFCDQE LQHRVESLAA FAERYVDKLQ
     ANQRSRYGLL IKAFSMTAAE TARRTREFRS PPQEQPTSLV ANLSPRDGSN QEPLGLPWPC
     DDYHAEGLDK QLSLMLPCVV SFPGSLQELV SHMVVRWAQE DFVQSPELVR AMFSLLHRQY
     DGLGELLRAL PRAYTISPSS VEDTMSLLEC LGQIRSLLIV QMGPQEENLM IQSIGNIMNN
     KVFYQHPNLM RALGMHETVM EVMVNVLGGG ESKEIRFPKM VTSCCRFLCY FCRISRQNQR
     SMFDHLSYLL ENSGIGLGEN PRGSTPLDVA AASVIDNNEL ALALQEQDLE KVVSYLAGCG
     LQSCPMLVAK GYPDIGWNPC GGERYLDFLR FAVFVNGESV EENANVVVRL LIRKPECFGP
     ALRGEGAYHL HNPHLLYNLK ALACLCLSGP SSACHSLVPP SFVCPPLVPT QLLTNHYERC
     WKYYCLPTGW ANFGVTSEEE LHLTRKLFWG IFDSLAHKKY DPELYRMAMP CLCAIAGALP
     PDYVDASYSS KAEKKATVDA EGNFDPRPVE TLNVIIPEKL DSFINKFAEY THEKWAFDKI
     QNNWSYGENI DEELKTHPML RPYKTFSEKG LEQGAWPDRE GMERRGPISP PPIFPLSSQT
     YDPREGYNPQ PPDLSAVTLS RELQAMAEQL AENYHNTWGR KKKQELEAKG GGTHPLLVPY
     DTLTAKEKAR DREKAQELLK FLQMNGYAVT RGLKDMELDS SSIEKRFAFG FLQQLLRWMD
     ISQEFIAHLE AVVSSGRVEK SPHEQEIKFF AKILLPLINQ YFTNHCLYFL STPAKVLGSG
     GHASNKEKEM ITRWAACDPR PSPLTSQDCN RLTVMKSGPE IVKAGLRSFF ESASEDIEKM
     VENLRLGKVS QARTQVKGVG QNLTYTTVAL LPVLTTLFQH IAQHQFGDDV ILDDVQVSCY
     RTLCSIYSLG TTKNTYVEKL RPALGESAMP VAFLEPQLNE YNAFSVYTTK SPRGAVLGLP
     NSVEEMCPDI PVLERLMADI GGLAESGARY TEMPHVIEIT LPMLCSYLPR WWERGPEAPP
     PALPAGAPPP CTAVTSDHLN SLLGNILRII VNNLGIDEAS WMKRLAVFAQ PIVSRARPEL
     LQSHFIPTIG RLRKRAGKVV SEEEQLRLEA KAEAQEGELL VRDEFSVLCR DLYALYPLLI
     RYVDNNRAQW LTEPNPSAEE LFRMVGEIFI YWSKSHNFKR EEQNFVVQNE INNMSFLTAD
     NKSKMAKVGS GGSDQERTKK KRRGDRYSVQ TSLIVATLKK MLPIGLNMCA PTDQDLITLA
     KTRYALKDTD EEVREFLHNN LHLQGKVEGS PSLRWQMALY RGVPGREEDA DDPEKIVRRV
     QEVSAVLYHL DQVGGAGGVF LLGLWARRRA RPSDVTPLPC RHRACNMFLE SYKAAWILTE
     DHSFEDRMID DLSKAGEQEE EEEEVEEKKP DPLHQLVLHF SRTALTEKSK LDEDYLYIAY
     ADIMAKAGLE SLDLPPWVCL PSQEKEMEKQ RLLYQQARLH TRGAAEMVLQ MISACKGETG
     AMVSSTLKLG ISILNGGNAE VQQKMLDYLK DKKEVGFFQS IQALMQTCSV LDLNAFERQN
     KAEGLGMVNE DGTVINRQNG NSPREKVMAD DEFTQDLFRF LQLLCEGHNN DFQNYLRTQT
     GNTTTINIII CTVDYLLRLQ ESISDFYWYY SGKDVIEEQG KRNFSKAMSV AKQVFNSLTE
     YIQGPCTGNQ QSLAHSRLWD AVVGFLHVFA HMMMKLAQDS SQIELLKELL DLQKDMVVML
     LSLLEGNVVN GMIARQMVDM LVESSSNVEM ILKFFDMFLK LKDIVGSEAF QDYVTDPRGL
     ISKKDFQKAM DSQKQFSGPE IQFLLSCSEA DENEMINCEE FANRFQEPAR DIGFNVAVLL
     TNLSEHVPHD PRLHNFLELA ESILEYFRPY LGRIEIMGAS RRIERIYFEI SETNRAQWEM
     PQVKESKRQF IFDVVNEGGE AEKMELFVSF CEDTIFEMQI AAATAVAALL WAAVTRAGPA
     GAGAAAGALS LLWGSLFGGG LVEGAKKVTV TELLAGMPDP TSDEVHGEQP AGPGGDADGE
     GASEGAGDAA EGAGDEEEAV HEAGPGGADG AVAVTDGGPF RPEGAGGLGD MGDTTPAEPP
     TPEGSPILKR KLGVDGVEEE LPPEPEPEPE LEPEKADAEN GEKEEIPEPP PEPPKKQAPP
     SPPPKKEEAG GEFWGELEVQ RVKFLNYLSR NFYTLRFLAL FLAFAINFIL LFYKVSDSPP
     GEEDMEGSAA GDVSGAGSGG GSGWGLGAGE EAEGDEDENM VYYFLEESTG YMEPALRCLS
     LLHTLVAFLC IIGYNCLKVP LVIFKREKEL ARKLEFDGPS PHLRVFVKRK VRGHGCTGSW
     IGSLPRIAEL LGMDLATLEI TAHNERKPDP PPGLLTWLMS IDVKYQIWKF GVIFTDNVSR
     VTYLSFYSRL TVLSHPGDTK RTSVCRALWL TLLIPALWAA KAGGSSEVKS LRPCAPLPQC
     YLFHMYVGVR AGGGIGDEIE DPAGDEYELY RVVFDITFFF FVIVILLAII QGLIIDAFGE
     LRDQQEQVKE DMETKCFICG IGSDYFDTTP HGFETHTLEE HNLANYMFFL MYLINKDETE
     HTGQESYVWK MYQERCWDFF PAGDCFRKQY EDQLS
//
DBGET integrated database retrieval system