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Database: UniProt
Entry: A0A2I3H0Y3_NOMLE
LinkDB: A0A2I3H0Y3_NOMLE
Original site: A0A2I3H0Y3_NOMLE 
ID   A0A2I3H0Y3_NOMLE        Unreviewed;      2728 AA.
AC   A0A2I3H0Y3;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 5.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 3 {ECO:0000313|Ensembl:ENSNLEP00000037170};
GN   Name=ITPR3 {ECO:0000313|Ensembl:ENSNLEP00000037170};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000037170, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000037170, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000037170}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
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DR   EMBL; ADFV01130918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130921; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSNLET00000058023; ENSNLEP00000037170; ENSNLEG00000008373.
DR   GeneTree; ENSGT00940000157078; -.
DR   Proteomes; UP000001073; Chromosome 1a.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2258   2283       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2295   2313       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2325   2345       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2381   2406       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2426   2448       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2555   2578       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    173       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    224       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      232    288       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      295    346       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      349    405       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       90    110       {ECO:0000256|SAM:Coils}.
FT   COILED     2686   2713       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2728 AA;  310628 MW;  C5ECD525DA1B714D CRC64;
     MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC
     PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS
     VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG
     DKVILNPVNA GQPLHASNYE LSDNAGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV
     VRLFHAEQEK FLTCDEYKGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
     NGLYRFKHLA TGNYLAAEVS RRSSTAGGCA HGNDIASLLS WTPHLQKTDS FVPRNSYVRL
     RHLCTNTWIQ STNVPIDIEE ERPIRLMLGT CPTKEDKEAF AIVSVPVSEI RDLDFANDAS
     SMLASAVEKL NEGFISQNDR RFVIQLLEDL VFFVSDVPNN GQNVLDIMVT KPNRERQKLM
     REQNILKQIF GILKAPFREK GGEGPLVRLE ELSDQKNAPY QHMFRLCYRV LRHSQEDYRK
     NQEHIAKQFG MMQSQIGYDI LAEDTITALL HNNRKLLEKH ITKTEVETFV SLVRKNREPR
     FLDYLSDLCV SNHIAIPVTQ ELICKCVLDP KNSDILIRTE LRPVKEMAQS HEYLSIEYSD
     EEVWLTWTDK NNEHHEKSVR QLAQEARAGN AHDENVLSYY RYQLKLFARM CLDRQYLAID
     EISQQLGVDL IFLCMADEML PFDLRASFCH LMLHVHVDRD PQELVTPVKF ARLWTEIPTA
     ITIKDYDSNL NASRDDKKNK FANTMEFVED YLNNVVSEAV PFANEEKNKL TFEVVSLAHN
     LIYFGFYSFS ELLRLTRTLL GIIDCVQGPP AMLQAYEDPG GKNVRRSIQG VGHMMSTMVL
     SRKQSVFSAP SLSAGASAAE PLDRSKFEEN EDIVVMETKL KILEILQFIL NVRLDYRISY
     LLSVFKKEFV EVFPMQDSGA DGTAPAFDST TANMNLDRIG EQAEAMFGVG KTSSMLEVDD
     EGGRMFLRVL IHLTMHDYAP LVSGALQLLF KHFSQRQEAM HTFKQVQLLI SAQDVENYKV
     IKSELDRLRT MVEKSELWVD KKGSSKGEEV EAGAAKDKKE VRALAHPPPL QILERLNKMC
     GVGEQMRKKQ QRLLKNMDAH KVMLDLLQIP YDKGDAKMME ILRYTHQFLQ KFCAGNPGNQ
     ALLHKHLHLF LTPGLLEAET MQHIFLNNYQ LCSEISEPVL QHFVHLLATH GRHVQYLDFL
     HTVIKAEGKY VKKCQDMIMT ELTNAGDDVV VFYNDKASLA HLLDMMKAAR DGVEDHSPLM
     YHISLVDLLA ACAEGKNVYT EIKCTSLLPL EDVVSVVTHE DCITEVKMAY VNFVNHCYVD
     TEVEMKEIYT SNHIWTLFEN FTLDMARVCS KREKRVADPT LEKYVLSVVL DTINAFFSSP
     FSENSTSLQT HQTIVVQLLQ STTRLLECPW LQQQHKGSVE ACIRTLAMVA KGRAILLPMD
     LDAHISSMLS SGASCAAAAQ RNASSYKATT RAFPRVTPTA NQWDYKNIIE KLQDIITALE
     ERLKPLVQAE LSVLVDVLHW PELLFLEGSE AYQRCESGGF LSKLIQHTKD LMESEEKLCI
     KVLRTLQQML LKKTKYGDRG NQLRKMLLQN YLQNRKSTSR GDXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXGLDPDWS AICRLDKEGA TKLVCDLITS
     TKNEKIFPGE HRPGHPLLDG GNTEIQKSFH NLMMSDKKSE RFFKVLHDRM KRAQQETKST
     VAVNMNDLGS QPHEDREPVD PTTKGRLASF SIPGSSSRCS LGPSLHRGHE VSERVQSNEM
     GTSVLIMQPI LRFLQLLCEN HNRDLQNFLR CQNNKTNYNL VCETLQFLDI MCGSTTGGLG
     LLGLYINEDN VGLVIQTLET LTEYCQGPCH ENQTCIVTHE SNGIDIITAL ILNDISPLCK
     YRMDLVLQLK DNASKLLLAL MESRHDSENA ERILISLRPQ ELVDVIKKAY LQEEERENSE
     VSPREVGHNI YILALQLSRH NKQLQHLLKP VKRIQEEEAE GISSMLSLNN KQLSQMLKSS
     VPAQEEEEDP LAYYENHTSQ IEIVRQDRSM EQIVFPVPGI CQFLTEETKH RLFTTTEQDE
     QGSKVSDFFD QSSFLHNEME WQRKLRSMPL IYWFSRRMTL WGSISFNLAV FINIIIAFFY
     PYMEGASTGV LDSPLISLLF WILICFSIAA LFTKRYSIRP LIVALILRSI YYLGIGPTLN
     ILGALNLTNK IVFVVSFVGN RGTFIRGYKA MVMDMEFLYH VGYILTSVLG LFAHELFYSI
     LLFDLIYREE TLFNVIKSVT RNGRSILLTA LLALILVYLF SIVGFLFLKD DFILEVDRLP
     NNHSTASPLG MPHGAAAFVD TCSGDKMDCV SGVSVPEVLE EDGELDSTER ACDTLLMCIV
     TVMNHGLRNG GGVGDILRKP SKDESLFPAR VVYDLLFFFI VIIIVLNLIF GVIIDTFADL
     RSEKQKKEEI LKTTCFICGL ERDKFDNKTV SFEEHIKLEH NMWNYLYFIV LVRVKNKTDY
     TGPESYVAQM IKNKNLDWFP RMRAMSLVSN EGEGEQNEIR ILQDKLNSTM KLVSHLTAQL
     NELKEQMTEQ RKRRQRLGFV DVQNCMSR
//
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