ID A0A2I3H140_NOMLE Unreviewed; 1800 AA.
AC A0A2I3H140;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
GN Name=PCDH15 {ECO:0000313|Ensembl:ENSNLEP00000037177.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000037177.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000037177.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000037177.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01114496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01114497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01114498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01114499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01114500; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01114501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01114502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01114503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01114504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01114505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000042619.1; ENSNLEP00000037177.1; ENSNLEG00000011914.3.
DR GeneTree; ENSGT00940000156675; -.
DR Proteomes; UP000001073; Chromosome 3.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0032420; C:stereocilium; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0048839; P:inner ear development; IEA:InterPro.
DR GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 8.
DR Gene3D; 2.60.40.3430; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 10.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR041149; EC_dom.
DR InterPro; IPR030718; EC_dom_sf.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF431; CADHERIN-RELATED FAMILY MEMBER 5-LIKE ISOFORM X1; 1.
DR Pfam; PF00028; Cadherin; 8.
DR Pfam; PF18432; ECD; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 10.
DR SUPFAM; SSF49313; Cadherin-like; 10.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 9.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1800
FT /note="Cadherin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014149099"
FT TRANSMEM 1263..1286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 106..223
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 236..353
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 354..467
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 468..604
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 606..706
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 707..813
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 814..922
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 924..1031
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1032..1146
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 1485..1507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1627..1650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1800 AA; 199180 MW; 6D5E84EEC1B1F582 CRC64;
MFSNNFLWFA GTILVDNMLI KGTAGGPDPT IELSLKDNVD YWVLMDPVKQ MLFLNSTGRV
LDRDPPMNIH SIVVQVQCIN KKVGTIIYHE VRIVVRDRND NSPTFKHESY YATVNELTPV
GTTIFTGFSG DNGATDIDDG PNGQIEYVIQ YNSDDPTSND TFEIPLMLTG NIVLRKRLNY
EDKTRYFVII QANDRAQNLN ERRTTTTTLT VDVLDGDDLG PVFLPCVLVP NTRDCRPLTY
QAAIPELRTP EELNPIIVTP PIQAIDQDRN IQPPSDRPGI LYSILVGTPE DYPRFFHMHP
RTAELSLLEP VNRDFHQKFD LVIKAEQDNG HPLPAFASLH IEILDENNQS PYFTMPSYQG
YILESAPVGA TISDSLNLTS PLRIVALDKD IEDTKDPELH LFLNDYTSVF TVTQTGITRY
LTLLQPVDRE EQQTYTFSIT AFDGVQESEP VIVNIQVMDA NDNTPTFPEI SYDVYVYTDM
RPGDSVIQLT AVDADEGSNG EITYEILVGA QGDFIINKTT GLITIAPGVE MIVGRTYALT
VQAADNAPLA ERSTGILTLG KALDRESTDR YILIITASDG RPGGTSTATV NIVVTDVNDN
APVFDPYLPR NLSVVEEEAN AFVGQVKATD PDAGINGQVH YSLGNFNNLF RITSNGSIYT
AVKLNREVRD YYELVVVATD GAVHPRHSTL TLAIKVLDID DNSPVFTNST YTVLVEENLP
AGTTILQIEA KDVDLGANVS YRIRSPEVKH FFALHPFTGE LSLLRSLDYE AFPDQEASIT
FLVEAFDIYG TMPPGIATVT VIVKDMNDYP PVFSKRIYKG MVAPDAVKGT PITTVYAEDA
DPPGLPASRV RYRIDDVQFP YPASIFDVEE DSGRVITRVN LNEEPTTIFK LVVVAFDDGE
PVMSSSATVK ILVLHPGEIP RFTQEEYRPP PVSELATKGT MVGVISAAAV NQSIVYSIVS
GNEEDTFGIN NITGIIYVNG PLDYETRTSY VLRVQADSLE VVLANLRVPS KSNTAKVYIE
IQDENNHPPV FQKKFYIGGV SEDARMFTSV LRVKATDKDT GNYSVMAYRL IIPPIKEGKE
GFVVETYTGL IKTAMLFHNM RRSYFKFQVI ATDDYGKGLS GKADVLVSVV NQLDMQVIVS
NVPPTLVEKK IEDLTEILDR YVQEQIPGAK VVVESIGARR HGDAFSLEDY TKCDLTVYAI
DPQTNRAIDR NELFKFLDGK LLDINKDFQP YYGEGGRILE IRTPEAVTSI KKRGESLGYT
EGALLALAFI IILCCIPAIL VVLVSYRQRQ AECTKTARIQ AALPAAKPAA PAPAPVAAPP
PPPPPPGAHL YEELGDSSIL FLLYHFQQSR GNNSVSEDRK HQQVVMPFSS NTIEAHKSAH
VDGSLLKSNK LKSARKFTFL SDEDDLSAHN PLYKENISQV STNSDISLRT DFVDPFLSKI
QAKSKSLRGP RGKIQRLWSQ SVSLPRRLMR KVPNRPEIID LQQWQGTRQK AENENTGICT
NKRGSSNPLL TTEEANLTEK EEIRQGETLI IKGTEQLKFL SSDSSSFCFP RPHFSFSTLP
TVSRTVELKS EPNVITSPAE CSLELSPSRP CILNSSLTRR ETPICMLAVE TERNIFENFA
HPPNISPSSA CPPPPPISPP SPPPAPAPLA PPPDISPFSL FFLPPPPPSI PCPPPPSASF
LSTECVCLTG VKCTTNMMPA EKIKSSMAQL STATVCKTDP QREPKGILRH VKNLAELEKS
VANMYSQIEK NYLRTNVSEL QTMCPSEVTN MEITSEQNKE NLNNIVEGTE KQSHSQSTSL
//
