ID A0A2I3H285_NOMLE Unreviewed; 1782 AA.
AC A0A2I3H285;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=FERM and PDZ domain containing 3 {ECO:0000313|Ensembl:ENSNLEP00000037651.1};
GN Name=FRMPD3 {ECO:0000313|Ensembl:ENSNLEP00000037651.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000037651.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000037651.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000037651.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01008088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01008089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01008090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01008091; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01008092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01008093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01008094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01008095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000033828.1; ENSNLEP00000037651.1; ENSNLEG00000013906.3.
DR GeneTree; ENSGT00950000183035; -.
DR InParanoid; A0A2I3H285; -.
DR OMA; VRDCKPY; -.
DR Proteomes; UP000001073; Chromosome X.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13183; FERM_C_FRMPD1_FRMPD3_FRMPD4; 1.
DR CDD; cd17169; FERM_F1_FRMPD3; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR049385; FAK1-like_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR041779; FRMPD1/3/4_FERM_C.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46221:SF1; FERM AND PDZ DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR46221; FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF21477; FERM_C_FAK1; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 48..125
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 174..488
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 515..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 897..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1266..1304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1321..1357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1725..1771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1006..1086
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1105..1120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1290..1304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1725..1752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1782 AA; 196147 MW; C533F5380C917BCA CRC64;
METLDSLLAA PGCSSPSSQQ ELFSSHVMQE ESANDMECEQ LPAEILRQVT IHRDPIYGFG
FVAGSERPVV VRSVRPGGPS ENKLLAGDQI VAINEEDVSE APRERLIELI RSAKEFIVLT
VLHTHQSPKS AFISAAKKAK LRSNPVKVRF SEQVAVGETD AKMMKKEALL LIPNVLKVFL
ENGQIKSFTF DGRTTVKDVM VTLQDRLSLR YIEHFALVLE YAGPEQNHKF LLLQDKQPLA
YVVQRTHYHG MKCLFRISFF PKDPVELLRR DPAAFEYLYI QSRNDVIRER FGMDPKPEML
LGLAALHIYI TVSATRPSQK ISLKNVEKEW GLEPFLPPSL LQGIKEKNLR KSLSQQLKAH
QTHPSCGTKG SAIQAKLQYL RILNELPTFT GVLFNTVGLD EKQSATTLLV GPRHGISHVI
DLKTNLTTVL SEFSKISKIQ LFRENQGVAR VETSIMDAKP LVLLMEWPEA TNFACLIAGY
CRLLLDSRKM VFSRPASQPL PPPMIKADYM HSAHRPVTGG HLGKKESSYV GSVGTSPRKS
SRCTPPPADS ELVSFCYLHM REQRKEQESR TDVNENLIFF EETRPRTKSD PTSKSSGQGY
EVVPDDFDAA SLDHEPCASR ARSYTLDNSL GAEALNFYCD SCKAKLQEQL GPRKGGKPGS
SRDNIVDLMS LPPPGSEEED XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXDHAQELDD ALVSTLITSP IPVPPGLIVL ATITPESSLD
SGHETNSSEL TDMSEMMSAM KQHQNTTYFL AQHLNKDSLL ARKDLPFRIQ SCAAQAVLTA
PYSLGRPDPN SSLQPIATGK SPGPPGARRK LPQSEGQVEG ERTYSLAVHP ALSPQLSEQK
NLSLLSPVPE DKGPGHTRAG LEMSLRAATS SLSEEQVSEL RDNLPKEVRL SPKLILDPKG
SVTPAIISAA LQQVVHSKSL VTAGGALGNP PSRGERRLEA SMGRPEVSMM SSSANKNLKF
KISPSAPETS RNSQHQLGAE VSSSPRAPTG SRSDSLHLSQ QEDRLPVQNF PPKSYLLRTS
RESVGKQATG EAVGKGGPEG GKPTLQKQGT ISSQGEKVQL ESTPKRSKLE ETSLVPRATY
PIALQSPSCQ SRSHSPSCQP HGHSPSSQSR GQSPSCQPRG QSPLRSQAAS RQVSTMPSRK
LETTLNGAHS TSEGPAKPKS SRGPFRLRNL FSATFPTRQK KETDERQAQL QKVKQYELEF
LEELLKPPSQ GELPGTEYLQ PPAPGRCSCQ LRSSPVQQGP GMSREQRRSC DCKRICRGGR
PQATQTPVPS LRGRERDRVL PSQRQPEAGP GVSLSSPINV RRIRSTSLES RECRSDPESG
VSCLTTCASG GECLGAPNYR KLMRRYSISE LDQGDRASLT SDVYPHPPLG MLPREAKEVE
TSLPIALGPK SRSLESPTLG DPFYVQVAPE TKGPRQMAVF SLPEEVYRKP AELDEDSESS
KCCSIRYCFY YRKCDMADDA SDGKDELSYS IPMKILPGMK LDEQVVPVVS RTLQVLDAAT
CSSSSPEASR TQEIDLRVST FEGSLAKINA LRAHAYGLPD GFLAARLDTN ELLTVLRQCV
ASPEARAPKP YVSQISEYKL ELALKFKELR ASCRRVANVD KSPTHMLAAI TGSFQVLSSL
IETFVRLVFI VRSEAQRQEL LAKVEEVVRN YTFLLRAAEE STARNLNQQQ QQQQQQQQQQ
QQQQQQQQVA AAAGAATEHP PGSPTSATVM STFTHSLKTL IK
//
