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Database: UniProt
Entry: A0A2I3H349_NOMLE
LinkDB: A0A2I3H349_NOMLE
Original site: A0A2I3H349_NOMLE 
ID   A0A2I3H349_NOMLE        Unreviewed;       227 AA.
AC   A0A2I3H349;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=Calcium-activated potassium channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE            Short=BKbeta {ECO:0000256|RuleBase:RU368097};
DE   AltName: Full=BK channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE   AltName: Full=Calcium-activated potassium channel, subfamily M subunit beta {ECO:0000256|RuleBase:RU368097};
DE   AltName: Full=Charybdotoxin receptor subunit beta {ECO:0000256|RuleBase:RU368097};
DE   AltName: Full=K(VCA)beta {ECO:0000256|RuleBase:RU368097};
DE   AltName: Full=Maxi K channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE   AltName: Full=Slo-beta {ECO:0000256|RuleBase:RU368097};
GN   Name=KCNMB2 {ECO:0000313|Ensembl:ENSNLEP00000038083.1};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000038083.1, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000038083.1, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000038083.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1
CC       (maxiK) channel. Modulates the calcium sensitivity and gating kinetics
CC       of KCNMA1, thereby contributing to KCNMA1 channel diversity.
CC       {ECO:0000256|RuleBase:RU368097}.
CC   -!- SUBUNIT: Interacts with KCNMA1 tetramer. There are probably 4 molecules
CC       of KCMNB per KCNMA1 tetramer. {ECO:0000256|RuleBase:RU368097}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU368097}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU368097}.
CC   -!- PTM: N-glycosylated. {ECO:0000256|RuleBase:RU368097}.
CC   -!- SIMILARITY: Belongs to the KCNMB (TC 8.A.14.1) family.
CC       {ECO:0000256|RuleBase:RU368097}.
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DR   EMBL; ADFV01170407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01170408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01170409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01170410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2I3H349; -.
DR   Ensembl; ENSNLET00000046174.1; ENSNLEP00000038083.1; ENSNLEG00000005652.2.
DR   GeneTree; ENSGT00950000183039; -.
DR   Proteomes; UP000001073; Chromosome 11.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0015269; F:calcium-activated potassium channel activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:UniProtKB-UniRule.
DR   Gene3D; 4.10.81.20; KCNMB2, ball/chain domain; 1.
DR   InterPro; IPR003930; K_chnl_Ca-activ_BK_bsu.
DR   InterPro; IPR037096; KCNMB2_ball/chain_dom_sf.
DR   InterPro; IPR015382; KCNMB2_ball_chain_dom.
DR   PANTHER; PTHR10258; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA; 1.
DR   PANTHER; PTHR10258:SF5; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-2; 1.
DR   Pfam; PF03185; CaKB; 1.
DR   Pfam; PF09303; KcnmB2_inactiv; 1.
DR   PRINTS; PR01450; BKCHANNELB.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|RuleBase:RU368097};
KW   Ion channel {ECO:0000256|RuleBase:RU368097};
KW   Ion transport {ECO:0000256|RuleBase:RU368097};
KW   Membrane {ECO:0000256|RuleBase:RU368097};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Transmembrane {ECO:0000256|RuleBase:RU368097};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU368097};
KW   Transport {ECO:0000256|RuleBase:RU368097}.
FT   TRANSMEM        39..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368097"
FT   TRANSMEM        192..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368097"
FT   DOMAIN          1..32
FT                   /note="KCNMB2 ball/chain"
FT                   /evidence="ECO:0000259|Pfam:PF09303"
SQ   SEQUENCE   227 AA;  26360 MW;  3A7DA58F76F0284D CRC64;
     MFIWTSGRTS SSYRHDEKRN IYQKIRDHDL LDKRKTDRAI LLGLAMMVCS IMMYFLLGIT
     LLRSYMQSVW TEESQCTLLN ASITETFNCS FSCGPDCWKL SQYPCLQVYV NLTSSGEKLL
     LYHTEETIKI NQKCSYIPKC GKNFEESMSL VNVVMENFRK YQHFSCYSDP EGNQKSVILT
     KLYSSNVLFH SLFWPTCMMA GGVAIVAMVK LTQYLSLLCE RIQRINR
//
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