ID A0A2I3H3S0_NOMLE Unreviewed; 372 AA.
AC A0A2I3H3S0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Cytohesin 4 {ECO:0000313|Ensembl:ENSNLEP00000038249.1};
GN Name=CYTH4 {ECO:0000313|Ensembl:ENSNLEP00000038249.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000038249.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000038249.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000038249.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01024377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024378; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3H3S0; -.
DR STRING; 61853.ENSNLEP00000038249; -.
DR Ensembl; ENSNLET00000043450.1; ENSNLEP00000038249.1; ENSNLEG00000027880.1.
DR GeneTree; ENSGT00940000160865; -.
DR InParanoid; A0A2I3H3S0; -.
DR OMA; LYNPNCK; -.
DR Proteomes; UP000001073; Chromosome 7b.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd01252; PH_GRP1-like; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF323; CYTOHESIN-4; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 32..219
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 237..353
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 372 AA; 43208 MW; C063BB32883C5DAE CRC64;
MDLCHPEPAE LSSGETEELQ RIKWHRKQLL EDIQRMAQKE KELCIGRKKF NMDPAKGIQY
FIEHKLLTPD IQDIARFLYK GEGLNKTAIG TYLGERDPIN LQVLQAFVDC HEFANLNLVQ
ALRQFLWSFR LPGEAQKIDR MMEAFATRYC LCNPGVFQST DTCYVLSFSI IMLNTSLHNP
NVRDRPPFER FVSMNRGINN GSDLPEDQLR NLFDSIKSEP FSIPEDDGND LTHTFFNPDR
EGWLLKLGGR VKTWKRRWFI LTDNCLYYFE FTTDKEPRGI IPLENLSVQK VDDPKKPFCL
ELYNPSCRGQ KIKACKTDGD GRVVEGKHES YRISATSAEE RDQWIQAIRA SITRVPFYDL
VSTRKKKIAS KH
//
