ID A0A2I3H7Z3_NOMLE Unreviewed; 777 AA.
AC A0A2I3H7Z3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=MARK2 {ECO:0000313|Ensembl:ENSNLEP00000039597.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000039597.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000039597.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000039597.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. SNF1 subfamily. {ECO:0000256|ARBA:ARBA00006234}.
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DR EMBL; ADFV01079336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01079337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01079338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01079339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01079340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01079341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01079342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01079343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01079344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01079345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3H7Z3; -.
DR Ensembl; ENSNLET00000060218.1; ENSNLEP00000039597.1; ENSNLEG00000004656.3.
DR GeneTree; ENSGT00940000155031; -.
DR Proteomes; UP000001073; Chromosome 4.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd12201; MARK2_C; 1.
DR CDD; cd14072; STKc_MARK; 1.
DR CDD; cd14406; UBA_MARK2; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.30.310.80; Kinase associated domain 1, KA1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR028375; KA1/Ssp2_C.
DR InterPro; IPR001772; KA1_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR049508; MARK1-4_cat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015940; UBA.
DR PANTHER; PTHR24346; MAP/MICROTUBULE AFFINITY-REGULATING KINASE; 1.
DR PANTHER; PTHR24346:SF56; SERINE_THREONINE-PROTEIN KINASE MARK2; 1.
DR Pfam; PF02149; KA1; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00627; UBA; 1.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF103243; KA1-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50032; KA1; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 43..293
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 312..351
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 728..777
FT /note="KA1"
FT /evidence="ECO:0000259|PROSITE:PS50032"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 86691 MW; B723E19D1C9047BF CRC64;
RTFTRTPLPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG KGNFAKVKLA
RHILTGKEVR TGTGDMHDPR YFIFQLFREV RIMKVLNHPN IVKLFEVIET EKTLYLVMEY
ASGGEVFDYL VAHGRMKEKE ARAKFRQIVS AVQYCHQKFI VHRDLKAENL LLDADMNIKI
ADFGFSNEFT FGNKLDTFCG SPPYAAPELF QGKKYDGPEV DVWSLGVILY TLVSGSLPFD
GQNLKELRER VLRGKYRIPF YMSTDCENLL KKFLILNPSK RGTLEQIMKD RWMNVGHEDD
ELKPYVEPLP DYKDPRRTEL MVSMGYTREE IQDSLVGQRY NEVMATYLLL GYKSSELEGD
TITLKPRPSA DLTNSSAPSP SHKVQRSVSA NPKQRRFSDQ AAGPAIPTSN SYSKKTQSNN
AENKRPEEDR ESGRKASSTA KVPASPLPGL ERKKTTPTPS TNSVLSTSTN RSRNSPLLER
ASLGQASIQN GKDSLTMPGS RASTASASAA VSAARPRQHQ KSMSASVHPN KASGLPPTES
NCEVPRPSTA PQRVPVASPS AHNISSSGGA PDRTNFPRGV SSRSTFHAGQ LRQVRDQQNL
PYGVTPASPS GHSQGRRGAS GSIFSKFTSK FVPLNSPSLC FLRNLNEPES KDRVETLRPH
VVGSGGNDKE KEEFREAKPR SLRFTWSMKT TSSMEPNEMM REIRKVLDAN SCQSELHEKY
MLLCMHGTPG HEDFVQWEME VCKLPRLSLN GVRFKRISGT SMAFKNIASK IANELKL
//
