ID A0A2I3H829_NOMLE Unreviewed; 482 AA.
AC A0A2I3H829;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Forkhead box protein P2 {ECO:0000256|ARBA:ARBA00040052};
GN Name=FOXP2 {ECO:0000313|Ensembl:ENSNLEP00000039784.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000039784.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000039784.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000039784.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR EMBL; ADFV01195536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3H829; -.
DR Ensembl; ENSNLET00000051202.1; ENSNLEP00000039784.1; ENSNLEG00000011394.3.
DR GeneTree; ENSGT00940000155480; -.
DR Proteomes; UP000001073; Chromosome 13.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd20065; FH_FOXP2; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047412; FH_FOXP1_P2.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR032354; FOXP-CC.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45796; FORKHEAD BOX P, ISOFORM C; 1.
DR PANTHER; PTHR45796:SF1; FORKHEAD BOX PROTEIN P2; 1.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16159; FOXP-CC; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 271..344
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 271..344
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 51..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..482
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 482 AA; 53532 MW; DD23F1931638EB0C CRC64;
EQRLEREQMF DTFEKQQKAT FFHFIAGLSP AEIQQLWKEV TGVHSMEDNG IKHGGLDLTT
NNSSSTTSST TSKASPPITH HSIVNGQSSV LNARRDSSSH EETGASHTLY GHGVCKWPGC
ESICEDFGQF LKHLNNEHAL DDRSTAQCRV QMQVVQQLEI QLSKERERLQ AMMTHLHMRP
SEPKPSPKPL NLVSSVTMSK NMLETSPQSL PQTPTTPTAP VTPITQGPSV ITPASVPNVG
AIRRRHSDKY NIPMSSEIAP NYEFYKNADV RPPFTYATLI RQAIMESSDR QLTLNEIYSW
FTRTFAYFRR NAATWKNAVR HNLSLHKCFV RVENVKGAVW TVDEVEYQKR RSQKITGSPT
LVKNIPTSLG YGAALNASLQ AALAESSLPL LSNPGLINNA SSGLLQAVHE DLNGSLDHID
SNGNSSPGCS PQPHIHSIHV KEEPVIAEDE DCPMSLVTTA NHSPELEDDR EIEEEPLSED
LE
//