ID A0A2I3H908_NOMLE Unreviewed; 747 AA.
AC A0A2I3H908;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Rho guanine nucleotide exchange factor 7 {ECO:0000313|Ensembl:ENSNLEP00000039967.1};
GN Name=ARHGEF7 {ECO:0000313|Ensembl:ENSNLEP00000039967.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000039967.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000039967.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000039967.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}.
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DR EMBL; ADFV01054186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01054187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01054188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01054189; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01054190; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01054191; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01054192; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01054193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01054194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01054195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3H908; -.
DR STRING; 61853.ENSNLEP00000039967; -.
DR Ensembl; ENSNLET00000034816.1; ENSNLEP00000039967.1; ENSNLEG00000007989.3.
DR GeneTree; ENSGT00940000155360; -.
DR InParanoid; A0A2I3H908; -.
DR Proteomes; UP000001073; Chromosome 5.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0098794; C:postsynapse; IEA:Ensembl.
DR GO; GO:0000322; C:storage vacuole; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0030032; P:lamellipodium assembly; IEA:Ensembl.
DR GO; GO:0060124; P:positive regulation of growth hormone secretion; IEA:Ensembl.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd12061; SH3_betaPIX; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035789; BetaPIX_SH3.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16615; RhoGEF67_u1; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 129..188
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 216..396
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 418..523
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 527..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 623..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 362..417
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 527..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..647
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 747 AA; 83944 MW; D4BF0AA489E566FC CRC64;
VYPEPRSESE CLSNIREFLR GCGASLRLEL LFPPSQPPQH LVTTILLSAS TFDANDLYQG
QNFNKVLSSL VTLNKVTADI GLGSDSVCAR PSSHRIKSFD SLGSQSLHTR TSKLFQGQYR
SLDMTDNSNN QLVVRAKFNF QQTNEDELSF SKGDVIHVTR VEEGGWWEGT LNGRTGWFPS
NYVREVKASE KPVSPKSGTL KSPPKGFDTT AINKSYYNVV LQNILETENE YSKELQTVLS
TYLRPLQTSE KLSSANISYL MGNLEEICSF QQMLVQSLEE CTKLPEAQQR VGGCFLNLMP
QMKTLYLTYC ANHPSAVNVL TEHSEELGEF METKGASSPG ILVLTTGLSK PFMRLDKYPT
LLKELERHME DYHTDRQDIQ KSMAAFKNLS AQCQEVRKRK ELELQILTEA IRNWEGDDIK
TLGNVTYMSQ VLIQCAGSEE KNERYLLLFP NVLLMLSASP RMSGFIYQGK LPTTGMTITK
LEDSENHRNA FEISGSMIER ILVSCNNQQD LQEWVDHLQK QTKVTSVGNP TIKPHSVPSH
TLPSHPVTPS CKHAHSKPAP LTPAYHTLPH PSHHGIPYTS IIWGPLDTPI SLTCSLNCLR
PVPTLRASFV LCYKEDLSKS PKTMKKLLPK RKPERKPSDE EFASRKSTAA LEEDAQILKV
IEAYCTSAKT RQTLNSTWQG TDLMHNHVLA DDDQPSLDSL GRRSSLSRLE PSDLSEDSDY
DSIWTAHSYR MGSTSRKSCC SYISHQN
//
