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Database: UniProt
Entry: A0A2I3H921_NOMLE
LinkDB: A0A2I3H921_NOMLE
Original site: A0A2I3H921_NOMLE 
ID   A0A2I3H921_NOMLE        Unreviewed;      2755 AA.
AC   A0A2I3H921;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 6.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 3 {ECO:0000313|Ensembl:ENSNLEP00000040000};
GN   Name=ITPR3 {ECO:0000313|Ensembl:ENSNLEP00000040000};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000040000, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000040000, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000040000}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
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DR   EMBL; ADFV01130918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130921; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSNLET00000054793; ENSNLEP00000040000; ENSNLEG00000008373.
DR   GeneTree; ENSGT00940000157078; -.
DR   Proteomes; UP000001073; Chromosome 1a.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:Ensembl.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR   GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
DR   GO; GO:0007613; P:memory; IEA:Ensembl.
DR   GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR   GO; GO:0050913; P:sensory perception of bitter taste; IEA:Ensembl.
DR   GO; GO:0050916; P:sensory perception of sweet taste; IEA:Ensembl.
DR   GO; GO:0050917; P:sensory perception of umami taste; IEA:Ensembl.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2285   2310       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2322   2340       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2352   2372       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2408   2433       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2453   2475       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2582   2605       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    173       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    224       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      232    288       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      295    352       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      360    416       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       90    110       {ECO:0000256|SAM:Coils}.
FT   COILED     2713   2740       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2755 AA;  313482 MW;  9C044FC714E982B3 CRC64;
     MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC
     PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS
     VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG
     DKVILNPVNA GQPLHASNYE LSDNAGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV
     VRLFHAEQEK FLTCDEYKGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
     NGLYRFKHLA TGNYLAAEVS RRQRASWGSC CVRSSTAGGC AHGNDIASLL SWTPHLQKTD
     SFVPRNSYVR LRHLCTNTWI QSTNVPIDIE EERPIRLMLG TCPTKEDKEA FAIVSVPVSE
     IRDLDFANDA SSMLASAVEK LNEGFISQND RRFVIQLLED LVFFVSDVPN NGQNVLDIMV
     TKPNRERQKL MREQNILKQI FGILKAPFRE KGGEGPLVRL EELSDQKNAP YQHMFRLCYR
     VLRHSQEDYR KNQEHIAKQF GMMQSQIGYD ILAEDTITAL LHNNRKLLEK HITKTEVETF
     VSLVRKNREP RFLDYLSDLC VSNHIAIPVT QELICKCVLD PKNSDILIRT ELRPVKEMAQ
     SHEYLSIEYS DEEVWLTWTD KNNEHHEKSV RQLAQEARAG NAHDENVLSY YRYQLKLFAR
     MCLDRQYLAI DEISQQLGVD LIFLCMADEM LPFDLRASFC HLMLHVHVDR DPQELVTPVK
     FARLWTEIPT AITIKDYDSN LNASRDDKKN KFANTMEFVE DYLNNVVSEA VPFANEEKNK
     LTFEVVSLAH NLIYFGFYSF SELLRLTRTL LGIIDCVQGP PAMLQAYEDP GGKNVRRSIQ
     GVGHMMSTMV LSRKQSVFSA PSLSAGASAA EPLDRSKFEE NEDIVVMETK LKILEILQFI
     LNVRLDYRIS YLLSVFKKEF VEVFPMQDSG ADGTAPAFDS TTANMNLDRI GEQAEAMFGV
     GKTSSMLEVD DEGGRMFLRV LIHLTMHDYA PLVSGALQLL FKHFSQRQEA MHTFKQVQLL
     ISAQDVENYK VIKSELDRLR TMVEKSELWV DKKGSSKGEE VEAGAAKDKK ERPTDEEGFL
     HPPGEKSSIL ERLNKMCGVG EQMRKKQQRL LKNMDAHKVM LDLLQIPYDK GDAKMMEILR
     YTHQFLQKFC AGNPGNQALL HKHLHLFLTP GLLEAETMQH IFLNNYQLCS EISEPVLQHF
     VHLLATHGRH VQYLDFLHTV IKAEGKYVKK CQDMIMTELT NAGDDVVVFY NDKASLAHLL
     DMMKAARDGV EDHSPLMYHI SLVDLLAACA EGKNVYTEIK CTSLLPLEDV VSVVTHEDCI
     TEVKMAYVNF VNHCYVDTEV EMKEIYTSNH IWTLFENFTL DMARVCSKRE KRVADPTLEK
     YVLSVVLDTI NAFFSSPFSE NSTSLQTHQT IVVQLLQSTT RLLECPWLQQ QHKGSVEACI
     RTLCAGALAS SKPLLLPLGR AILLPMDLDA HISSMLSSGA SCAAAAQRNA SSYKATTRAF
     PRVTPTANQW DYKNIIEKLQ DIITALEERL KPLVQAELSV LVDVLHWPEL LFLEGSEAYQ
     RCESGGFLSK LIQHTKDLME SEEKLCIKVL RTLQQMLLKK TKYGDRGNQL RKMLLQNYLQ
     NRKSTSRGDX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     GLDPDWSAIC RLDKEGATKL VCDLITSTKN EKIFPGEHRP GHPLLDGGNT EIQKSFHNLM
     MSDKKSERFF KVLHDRMKRA QQETKSTVAV NMNDLGSQPH EDREPVDPTT KGRLASFSIP
     GSSSRCSLGP SLHRGHEVSE RVQSNEMGTS VLIMQPILRF LQLLCENHNR DLQNFLRCQN
     NKTNYNLVCE TLQFLDIMCG STTGGLGLLG LYINEDNVGL VIQTLETLTE YCQGPCHENQ
     TCIVTHESNG IDIITALILN DISPLCKYRM DLVLQLKDNA SKLLLALMES RHDSENAERI
     LISLRPQELV DVIKKAYLQE EERENSEVSP REVGHNIYIL ALQLSRHNKQ LQHLLKPVKR
     IQEEEAEGIS SMLSLNNKQL SQMLKSSVPA QEEEEDPLAY YENHTSQIEI VRQDRSMEQI
     VFPVPGICQF LTEETKHRLF TTTEQDEQGS KVSDFFDQSS FLHNEMEWQR KLRSMPLIYW
     FSRRMTLWGS ISFNLAVFIN IIIAFFYPYM EGASTGVLDS PLISLLFWIL ICFSIAALFT
     KRYSIRPLIV ALILRSIYYL GIGPTLNILG ALNLTNKIVF VVSFVGNRGT FIRGYKAMVM
     DMEFLYHVGY ILTSVLGLFA HELFYSILLF DLIYREETLF NVIKSVTRNG RSILLTALLA
     LILVYLFSIV GFLFLKDDFI LEVDRLPNNH STASPLGMPH GAAAFVDTCS GDKMDCVSGV
     SVPEVLEEDG ELDSTERACD TLLMCIVTVM NHGLRNGGGV GDILRKPSKD ESLFPARVVY
     DLLFFFIVII IVLNLIFGVI IDTFADLRSE KQKKEEILKT TCFICGLERD KFDNKTVSFE
     EHIKLEHNMW NYLYFIVLVR VKNKTDYTGP ESYVAQMIKN KNLDWFPRMR AMSLVSNEGE
     GEQNEIRILQ DKLNSTMKLV SHLTAQLNEL KEQMTEQRKR RQRLGFVDVQ NCMSR
//
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