ID A0A2I3H950_NOMLE Unreviewed; 541 AA.
AC A0A2I3H950;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Tripartite motif containing 46 {ECO:0000313|Ensembl:ENSNLEP00000040025.1};
GN Name=TRIM46 {ECO:0000313|Ensembl:ENSNLEP00000040025.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000040025.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000040025.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000040025.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; ADFV01183572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01183573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01183574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3H950; -.
DR Ensembl; ENSNLET00000046152.1; ENSNLEP00000040025.1; ENSNLEG00000011882.3.
DR GeneTree; ENSGT00940000158021; -.
DR Proteomes; UP000001073; Chromosome 12.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19786; Bbox2_TRIM46_C-I; 1.
DR CDD; cd00063; FN3; 1.
DR CDD; cd16757; RING-HC_TRIM46_C-I; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 4.10.830.40; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR017903; COS_domain.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR040859; Midline-1_COS.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24099; E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED; 1.
DR PANTHER; PTHR24099:SF20; TRIPARTITE MOTIF-CONTAINING PROTEIN 46; 1.
DR Pfam; PF18568; COS; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51262; COS; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 209..250
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 357..414
FT /note="COS"
FT /evidence="ECO:0000259|PROSITE:PS51262"
FT DOMAIN 416..515
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 54..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 541 AA; 60709 MW; B8CB0A9554AF6C14 CRC64;
MAAKRGTKTS MKNMEKELLC PVCQEMYKQP LVLPCTHNVC QACAREVLGQ QGYIGHGGDP
SSEPTSPAST PSTRSPRLSR RTLPKPDRLD RLLKSGFGTY PGRKRGALHP QVIMFPCPAC
QGDVELGERG LAGLFRNLTL ERVVERYRQS VSVGGAILCQ LCKPPPLEAT KGCTECRATF
CNECFKLFHP WGTQKAQHEP TLPTLSFRPK GLMCPDHKEE VTHYCKTCQR LVCQLCRVRR
THSGHKITPV LSAYQALKDK LTKSLTYILG NQDTVQTQIC ELEEAVRHTE VSGQQAKEEV
SQLVRGLGAV LEEKRASLLQ AIEECQQERL ARLSAQIQEH RSLLDGSGLV GYAQEVLKET
DQPCFVQAAK QLHNRIARAT EALQTFRPAA SSSFRHCQLD VGREMKLLTE LNFLRVPEAP
VIDTQRTFAY DQIFLCWRLP PHSPPAWHYT VEFRRTDVPA QPGPTRWQRR EEVRGTSALL
ENPDTGSVYV LRVRGCNKAG YGEYSEDVHL HTPPAPGTTR TAGTTAVLRM PQWRRRRPSL
S
//
