ID A0A2I3H9V4_NOMLE Unreviewed; 2137 AA.
AC A0A2I3H9V4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN Name=CACNA1G {ECO:0000313|Ensembl:ENSNLEP00000040256.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000040256.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000040256.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000040256.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. This channel gives rise to T-type calcium
CC currents. T-type calcium channels belong to the "low-voltage activated
CC (LVA)" group and are strongly blocked by nickel and mibefradil. A
CC particularity of this type of channels is an opening at quite negative
CC potentials, and a voltage-dependent inactivation. T-type channels serve
CC pacemaking functions in both central neurons and cardiac nodal cells
CC and support calcium signaling in secretory cells and vascular smooth
CC muscle. They may also be involved in the modulation of firing patterns
CC of neurons which is important for information processing as well as in
CC cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR EMBL; ADFV01070083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01070084; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01070085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01070086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01070087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01070088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01070089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01070090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01070091; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01070092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000046590.1; ENSNLEP00000040256.1; ENSNLEG00000007757.3.
DR GeneTree; ENSGT00940000159664; -.
DR Proteomes; UP000001073; Chromosome 14.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR005445; VDCC_T_a1.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF137; VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01629; TVDCCALPHA1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808}; Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|RuleBase:RU003808};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022568, ECO:0000256|RuleBase:RU003808};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 813..832
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 889..912
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1225..1243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1263..1287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1358..1380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1460..1483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1558..1579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1591..1614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1668..1686
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1706..1723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1769..1791
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 86..380
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 769..918
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1223..1493
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1557..1801
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 673..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 995..1178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1818..1877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1955..2009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2040..2137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1492..1519
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 470..484
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..691
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 995..1024
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1066
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1097..1120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 329
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 871
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1432
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 2137 AA; 236259 MW; ABA9BC3296AF3866 CRC64;
MDEEEDGAGA EESGQPRRFM RLNDLSRAGG RPGPGSAEKD PGSADSEVEG LPYPALAPVV
FLYLSQDSRP RRWCLRTVCN PYPSGTWFER ISMLVILLNC VTLGMFRPCE DIACDSQRCR
ILQAFDDFIF AFFAVEMVVK MVALGIFGKK CYLGDTWNRL DFFIVIAGTV RVLRPLRAIN
RVPSMRILVT LLLDTLPMLG NVLLLCFFVF FIFGIVGVQL WAGLPLSVDL ERYYQTENED
ESPFICSQPR ENGMRSCRSV PTLRGEGGGG PPCGLDYEAY NSSSNTTCVN WNQYYTNCSA
GEHNPFKGAI NFDNIGYAWI AIFQVITLEG WVDIMYFVMD AHSFYNFIYF ILLIIVGSFF
MINLCLVVIA TQFSETKQRE SQLMREQRVR FLSNASTLAS FSEPGSCYEE LLKYLVYILR
KAARRLAQVS RAAGVRAGLL SSPAPLGGQE TQPSSSCSRS HRRLSVHHLV HHHHHHHHHY
HLGNGTLRAP RASPEIQDRD ANGSRRLMLP PPSTPALSGG PPGGAESVHS FYHADCHLEP
VRCQAPPPRS PSEASGRTVG SGKVYPTVHT SPPPETLKEK ALVEVAASSG PPTLTSLNIP
PGPYSSMHKL LETQSTGTCQ SSCKISSPCL KADSGACGPD SCPYCARAGA GEVELADREM
PDSDSEAVYE FTQDAQHRDL RDPHSRRQRS LGPDAEPSSV LAFWRLICDT FRKIVDSKYF
GRGIMIAILV NTLSMGIEYH EQVGVWAEAG LLVKVQGAQA ACPLCSVWEI VGQQGGGLSV
LRTFRLMRVL KLVRFLPALQ RQLVVLMKTM DNVATFCMLL MLFIFIFSIL GMHLFGCKFA
SERDGDTLPD RKNFDSLLWA IVTVFQILTQ EDWNKVLYNG MASTSSWAAL YFIALMTFGN
YVLFNLLVAI LVEGFQAEEI SKREDASGQL SCIQLPVDSQ GGDANKSESE PDFFSPSLDG
DGDRKKCLAL VSLGEHPELR KSLLPPLIIH TAATPMSLPK STSTGLGEAL GPASRRTSSS
GSAEPGAAHE MKSPPSARSS PHSPWSAASS WTSRRSSRNS LGRAPSLKRR SPSGERRSLL
SGEGQESQDE EESSEEERAS PAGSDRHHRG SLEREAKSSF DLPDTLQVPG LHRTASGRGS
ASEHQDCNGK SASGRLARAL RPDDPPLDGD DADDEGNLSK GERVRAWIRA RLPACCLERD
SWSAYIFPPQ SRFRLLCHRI ITHKMFDHVV LVIIFLNCIT IAMERPKIDP HSAERIFLTL
SNYIFTAVFL AEMTVKVMGA GVGLAGILRS SWNVLDGLLV LISVIDILVS MVSDSGTKIL
GMLRVLRLLR TLRPLRVISR AQGLKLVVET LMSSLKPIGN IVVICCAFFI IFGILGVQLF
KGKFFVCQGE DTRNITNKSD CAEASYRWVR HKYNFDNLGQ ALMSLFVLAS KDGWVDIMYD
GLDAVGVDQQ PIMNHNPWML LYFISFLLIV AFFVLNMFVG VVVENFHKCR QHQEEEEARR
REEKRLRRLE KKRRNLMLDD VIASGSSASA ASEAQCKPYY SDYSRFRLLV HHLCTSHYLD
LFITGVIGLN VVTMAMEHYQ QPQILDEALK ICNYIFTVIF VLESVFKLVA FGFRRFFQDR
WNQLDLAIVL LSIMGITLEE IEVNASLPIN PTIIRIMRVL RIARVLKLLK MAVGMRALLD
TVMQALPQVH RFYFFSSFPG GEPGTSLHVV FFIFAALGVE LFGDLVSWGR GVSTGDNWNW
HYEGKGLGLD TLRDCDQEST CYNTVISPIY FVSFVLTAQF VLVNVVIAVL MKHLEESNKE
AKEEAELEAE LELEMKTLSP QPHSPLGSPF LWPGVEGPDS PDSPKPGAPH PAAHARSASH
FSLQHPTMQP HPTELPGPDL LTVRKSGVSR THSLPNDSYM CRHGSTAEGP LGHRGWGLPK
AQSGSVLSVH SQPADTSYIL QLPKDAPHLL QPHSTPTWGT IPKLPPPGRS PLAQRPLRRQ
AAIRTDSLDV QGLGSREDLL AEEPPSPRDL KKCYSVEAQS CQRRATSWLD EQRRHSIAVS
CLDSGSQPHL GTDPSNLGGH RPKKKLSPPS ISIDPPESQG PRPLPSPGVC LRRRAPSSDS
KEPLASGPPD SMAASPSPKK DVLSLSGLSS DPADLDP
//
