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Database: UniProt
Entry: A0A2I3HA68_NOMLE
LinkDB: A0A2I3HA68_NOMLE
Original site: A0A2I3HA68_NOMLE 
ID   A0A2I3HA68_NOMLE        Unreviewed;      2749 AA.
AC   A0A2I3HA68;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 5.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 3 {ECO:0000313|Ensembl:ENSNLEP00000040390};
GN   Name=ITPR3 {ECO:0000313|Ensembl:ENSNLEP00000040390};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000040390, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000040390, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000040390}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
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DR   EMBL; ADFV01130918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130921; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSNLET00000040584; ENSNLEP00000040390; ENSNLEG00000008373.
DR   GeneTree; ENSGT00940000157078; -.
DR   Proteomes; UP000001073; Chromosome 1a.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2279   2304       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2316   2334       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2346   2366       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2402   2427       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2447   2469       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2576   2599       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    173       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    224       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      232    288       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      295    352       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      360    416       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       90    110       {ECO:0000256|SAM:Coils}.
FT   COILED     2707   2734       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2749 AA;  312797 MW;  E43691D446DFFD6B CRC64;
     MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC
     PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS
     VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG
     DKVILNPVNA GQPLHASNYE LSDNAGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV
     VRLFHAEQEK FLTCDEYKGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
     NGLYRFKHLA TGNYLAAEVS RRQRASWGSC CVRSSTAGGC AHGNDIASLL SWTPHLQKTD
     SFVPRNSYVR LRHLCTNTWI QSTNVPIDIE EERPIRLMLG TCPTKEDKEA FAIVSVPVSE
     IRDLDFANDA SSMLASAVEK LNEGFISQND RRFVIQLLED LVFFVSDVPN NGQNVLDIMV
     TKPNRERQKL MREQNILKQI FGILKAPFRE KGGEGPLVRL EELSDQKNAP YQHMFRLCYR
     VLRHSQEDYR KNQEHIAKQF GMMQSQIGYD ILAEDTITAL LHNNRKLLEK HITKTEVETF
     VSLVRKNREP RFLDYLSDLC VSNHIAIPVT QELICKCVLD PKNSDILIRT ELRPVKEMAQ
     SHEYLSIEYS DEEVWLTWTD KNNEHHEKSV RQLAQEARAG NAHDENVLSY YRYQLKLFAR
     MCLDRQYLAI DEISQQLGVD LIFLCMADEM LPFDLRASFC HLMLHVHVDR DPQELVTPVK
     FARLWTEIPT AITIKDYDSN LNASRDDKKN KFANTMEFVE DYLNNVVSEA VPFANEEKNK
     LTFEVVSLAH NLIYFGFYSF SELLRLTRTL LGIIDCVQGP PAMLQAYEDP GGKNVRRSIQ
     GVGHMMSTMV LSRKQSVFSA PSLSAGASAA EPLDRSKFEE NEDIVVMETK LKILEILQFI
     LNVRLDYRIS YLLSVFKKEF VEVFPMQDSG ADGTAPAFDS TTANMNLDRI GEQAEAMFGV
     GKTSSMLEVD DEGGRMFLRV LIHLTMHDYA PLVSGALQLL FKHFSQRQEA MHTFKQVQLL
     ISAQDVENYK VIKSELDRLR TMVEKSELWV DKKGSSKGEE VEAGAAKDKK EVRALAHPPP
     LQILERLNKM CGVGEQMRKK QQRLLKNMDA HKVMLDLLQI PYDKGDAKMM EILRYTHQFL
     QKFCAGNPGN QALLHKHLHL FLTPGLLEAE TMQHIFLNNY QLCSEISEPV LQHFVHLLAT
     HGRHVQYLDF LHTVIKAEGK YVKKCQDMIM TELTNAGDDV VVFYNDKASL AHLLDMMKAA
     RDGVEDHSPL MYHISLVDLL AACAEGKNVY TEIKCTSLLP LEDVVSVVTH EDCITEVKMA
     YVNFVNHCYV DTEVEMKEIY TSNHIWTLFE NFTLDMARVC SKREKRVADP TLEKYVLSVV
     LDTINAFFSS PFSENSTSLQ THQTIVVQLL QSTTRLLECP WLQQQHKGSV EACIRTLCAG
     ALASSKPLLL PLGRAILLPM DLDAHISSML SSGASCAAAA QRNASSYKAT TRAFPRVTPT
     ANQWDYKNII EKLQDIITAL EERLKPLVQA ELSVLVDVLH WPELLFLEGS EAYQRCESGG
     FLSKLIQHTK DLMESEEKLC IKVLRTLQQM LLKKTKYGDR GNQLRKMLLQ NYLQNRKSTS
     RGDXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXGLDPDW
     SAICRLDKEG ATKLVCDLIT STKNEKIFPG EHRPGHPLLD GGNTEIQKSF HNLMMSDKKS
     ERFFKVLHDR MKRAQQETKS TVAVNMNDLG SQPHEDREPV DPTTKGRLAS FSIPGSSSRC
     SLGPSLHRGH EVSERVQSNE MGTSVLIMQP ILRFLQLLCE NHNRDLQNFL RCQNNKTNYN
     LVCETLQFLD IMCGSTTGGL GLLGLYINED NVGLVIQTLE TLTEYCQGPC HENQTCIVTH
     ESNGIDIITA LILNDISPLC KYRMDLVLQL KDNASKLLLA LMESRHDSEN AERILISLRP
     QELVDVIKKA YLQEEERENS EVSPREVGHN IYILALQLSR HNKQLQHLLK PVKRIQEEEA
     EGISSMLSLN NKQLSQMLKS SVPAQEEEED PLAYYENHTS QIEIVRQDRS MEQIVFPVPG
     ICQFLTEETK HRLFTTTEQD EQGSKVSDFF DQSSFLHNEM EWQRKLRSMP LIYWFSRRMT
     LWGSISFNLA VFINIIIAFF YPYMEGASTG VLDSPLISLL FWILICFSIA ALFTKRYSIR
     PLIVALILRS IYYLGIGPTL NILGALNLTN KIVFVVSFVG NRGTFIRGYK AMVMDMEFLY
     HVGYILTSVL GLFAHELFYS ILLFDLIYRE ETLFNVIKSV TRNGRSILLT ALLALILVYL
     FSIVGFLFLK DDFILEVDRL PNNHSTASPL GMPHGAAAFV DTCSGDKMDC VSGVSVPEVL
     EEDGELDSTE RACDTLLMCI VTVMNHGLRN GGGVGDILRK PSKDESLFPA RVVYDLLFFF
     IVIIIVLNLI FGVIIDTFAD LRSEKQKKEE ILKTTCFICG LERDKFDNKT VSFEEHIKLE
     HNMWNYLYFI VLVRVKNKTD YTGPESYVAQ MIKNKNLDWF PRMRAMSLVS NEGEGEQNEI
     RILQDKLNST MKLVSHLTAQ LNELKEQMTE QRKRRQRLGF VDVQNCMSR
//
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