ID A0A2I3HAG9_NOMLE Unreviewed; 1276 AA.
AC A0A2I3HAG9;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=ALF transcription elongation factor 2 {ECO:0000313|Ensembl:ENSNLEP00000040639.1};
GN Name=AFF2 {ECO:0000313|Ensembl:ENSNLEP00000040639.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000040639.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000040639.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000040639.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
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DR EMBL; ADFV01068631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01068632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01068633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01068634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01068635; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01068636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01068637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01068638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01068639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01068640; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012354162.1; XM_012498708.1.
DR AlphaFoldDB; A0A2I3HAG9; -.
DR Ensembl; ENSNLET00000046946.1; ENSNLEP00000040639.1; ENSNLEG00000013346.2.
DR GeneID; 100580859; -.
DR CTD; 2334; -.
DR GeneTree; ENSGT00950000182974; -.
DR OrthoDB; 4254515at2759; -.
DR Proteomes; UP000001073; Chromosome X.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 6.10.250.2670; -; 1.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR043639; AF4_int.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF18; AF4_FMR2 FAMILY MEMBER 2; 1.
DR Pfam; PF05110; AF-4; 2.
DR Pfam; PF18875; AF4_int; 1.
DR Pfam; PF18876; AFF4_CHD; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 1021..1275
FT /note="AF4/FMR2 C-terminal homology"
FT /evidence="ECO:0000259|Pfam:PF18876"
FT REGION 96..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..578
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..678
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..833
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..878
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1276 AA; 140977 MW; BCF4F1593E8686FE CRC64;
MDLFDFFRDW DLEQQCHYEQ DRSALKKREW ERRNQEVQQE DDLFSSGFDL FGEPYKVAEY
TNKGDALANR VQNTLGNYDE MKDLLTNHSN QNHLVGIPKN SVPQNPINKN EPSFFPEQKN
RIIPPHQDNT HPSAPMPPPS VVILNSTLIH SNRKSKPEWS RDSHNPSTVL ASQASGQPNK
MQTLTQDQSQ AKLEDFFVYP AEQPQTGEVE ESNPSTKEDS NPKSSGEDAF KEIFQSNSPE
ESEFAVQAPG SPLVASSLLA PSSGLSVQNF PPGLYCKTSM GQQKPTAYVR PMDGQDQAPD
ISPTLKPSIE FENSFGNLSF GTLLDGKPSA ASSKTKLPKF TILQTSEVSL PSDPSCVEEI
LRESQHLTPG FTLQKWNDPT TRASTKMLED DLKLSSDEDD LEPVKTLTTQ CTATELYQAV
EKAKPRNNPV NPPLATPQPP PAVQASGGSG SSSESESSSE SDSDTESSTT DSESNEAPRV
ATPEPEPPST NKWQLDKWLN KVTSQNKSFI CGQNETPMET ISLPPPIIQP MEVQMKAKTN
ASQVPAEPKE RPLLSLIREK ARPRPTQKIP ETKALKHKLS TTSETVSQRT IGKKQPKKVE
KNTSIDEFTW PKPNITSSTP KEKESVELHD PPRGRNKATA HKPAPRKEPR PNIPLAPEKK
KYRGPGKIVP KSREFIETDS STSDSNTDQE ETLQIKVLPP CIISGGNTAK SKEICGASLT
LSTLMSSSGS NNNLSISNEE PTFSPIPVMQ TEMLSPLQDH ENLKNLWVKI DLDLLSRVPG
HNSLHAAPAK PDHKETATKP KRQTTVTAVE KPAPKGKRKH KPTEVAEKIP EKKQRLEEAT
TICLLPPCIS PAPPHKPPNT RENNSSRRAN RRKEEKLFPP PLSPLPEDPP RRRNVSGNNG
PFGQDKNIAM TGQVTSTKPK RTEGKFCATF KGISVNEGDT PKKASSATIT VTNTAIATAT
VTATAIVTTT VTATATATAT TTTTTTTIST ITSTITTGLM DSSHLEMTSW AALPLLSSSS
TNVRRPKLTF DDSVHNADYY MQEAKKLKHK ADALFEKFGK AVNYADAALS FTECGNAMER
DPLEAKSPYT MYSETVELLR YAMRLKNFAS PLASDGDKKL AVLCYRCLSL LYLRMFKLKK
DHAMKYSRSL MEYFKQNASK VAQIPSPWVG NGKNTPSPVS LNNVSPINAM GNCNNGPVTI
PQRIHHMAAS HVNITSNVLR GYEHWDMADK LTRENKEFFG DLDTLMGPLT QHSSMTNLVR
YVRQGLCWLR IDAHLL
//
