ID A0A2I3HBX5_NOMLE Unreviewed; 435 AA.
AC A0A2I3HBX5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Metaxin-1 {ECO:0000256|ARBA:ARBA00039748};
DE AltName: Full=Mitochondrial outer membrane import complex protein 1 {ECO:0000256|ARBA:ARBA00042095};
GN Name=MTX1 {ECO:0000313|Ensembl:ENSNLEP00000041153.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000041153.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000041153.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000041153.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in transport of proteins into the mitochondrion.
CC Essential for embryonic development. {ECO:0000256|ARBA:ARBA00037753}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004294}.
CC -!- SIMILARITY: Belongs to the metaxin family.
CC {ECO:0000256|ARBA:ARBA00009170}.
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DR EMBL; ADFV01183578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01183579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01183580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3HBX5; -.
DR Ensembl; ENSNLET00000035756.1; ENSNLEP00000041153.1; ENSNLEG00000011933.2.
DR GeneTree; ENSGT00950000182919; -.
DR Proteomes; UP000001073; Chromosome 12.
DR GO; GO:0001401; C:SAM complex; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd03212; GST_C_Metaxin1_3; 1.
DR CDD; cd03078; GST_N_Metaxin1_like; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR019564; Sam37/metaxin_N.
DR PANTHER; PTHR12289; METAXIN RELATED; 1.
DR PANTHER; PTHR12289:SF34; METAXIN-1; 1.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF10568; Tom37; 2.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG01180; SUF1; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 390..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 172..226
FT /note="Mitochondrial outer membrane transport complex
FT Sam37/metaxin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10568"
FT DOMAIN 228..262
FT /note="Mitochondrial outer membrane transport complex
FT Sam37/metaxin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10568"
FT DOMAIN 292..355
FT /note="Metaxin glutathione S-transferase"
FT /evidence="ECO:0000259|Pfam:PF17171"
FT REGION 1..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 435 AA; 48111 MW; 6CC44226C070866C CRC64;
MLLGGPPRSP RSGTSPKGPR SSTRHVQFGK SPQTWPRRTR PRSPEPAAPS GVRGSTWPRR
RDSPRRAGPT VLSRYVGHLW MGRRPPSPEA RGPVPRSSVA SRARRSLASP GTSLGPLTAT
TGGAVAGGGP MHGRVEAHKE VFPGQRAGKM AAPMELFCWS GGWGLPSVDL DSLAVLTYAR
FTGAPLKVHK ISNPWRSPSG TLPALRTSHG EVISVPHKII THLRKEVHTF WIDTKNYVEV
TRKWYAEAMP FPLNFFLPGR MQRQYMERLQ LLTGEHRPED EEELEKELYR EARECLTLLS
QRLGSQKFFF GDAPASLDAF IFSYLALLLQ AKLPSGKLQV HLRGLHNLCA YCTNILSLYF
PWDGAEVPPQ RQTPAGPETE EEPYRRRNQI LSVLAGLAAM VGYALLSGIV SIQRATPARA
PGTRTLGMAE EDEEE
//
