ID A0A2I3HBZ4_NOMLE Unreviewed; 703 AA.
AC A0A2I3HBZ4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=ROCK2 {ECO:0000313|Ensembl:ENSNLEP00000041017.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000041017.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000041017.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000041017.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00009903}.
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DR EMBL; ADFV01073212; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01073213; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01073214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01073215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01073216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01073217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3HBZ4; -.
DR SMR; A0A2I3HBZ4; -.
DR Ensembl; ENSNLET00000046728.1; ENSNLEP00000041017.1; ENSNLEG00000014043.2.
DR GeneTree; ENSGT01030000234517; -.
DR OMA; NSQWIVQ; -.
DR Proteomes; UP000001073; Chromosome 19.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:UniProtKB-UniRule.
DR CDD; cd20875; C1_ROCK2; 1.
DR CDD; cd01242; PH_ROCK; 1.
DR CDD; cd22250; ROCK_SBD; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.20.5.730; Single helix bin; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015008; ROCK_Rho-bd_dom.
DR PANTHER; PTHR22988; MYOTONIC DYSTROPHY S/T KINASE-RELATED; 1.
DR PANTHER; PTHR22988:SF28; RHO-ASSOCIATED PROTEIN KINASE 2; 1.
DR Pfam; PF08912; Rho_Binding; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF103652; G protein-binding domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51859; RHO_BD; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01206, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 294..362
FT /note="RhoBD"
FT /evidence="ECO:0000259|PROSITE:PS51859"
FT DOMAIN 465..664
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 575..630
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 660..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 9..324
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 371..416
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 678..703
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 703 AA; 82149 MW; 23BDD34321929F96 CRC64;
MEIDMTYQLK VIQQSLEQEE AEHKATKARL ADKNKIYESI EEAKSEAMKE MEKKLLEERT
LKQKVENLLL EAEKRCSLLD CDLKQSQQKI NELLKQKDVL NEDVRNLTLK IEQETQKRCL
TQNDLKMQTQ QVNTLKMSEK QLKQENNHLM EMKMNLEKQN AELRKERQDA DGQMKELQDQ
LEAEQYFSTL YKTQVRELKE ECEEKTKLGK ELQQKKQELQ DERDSLAAQL EITLTKADSE
QLARSIAEEQ YSDLEKEKIM KELEIKEMMA RHKQELTEKD ATIASLEETN RTLTSDVANL
ANEKEELNNK LKDVQEQLSR LKDEEISAAA IKAQFEKQLL TERTLKTQAV NKLAEIMNRK
EPVKRGNDTD VRRKEKENRK LHMELKSERE KLTQQMIKYQ KELNEMQAQI AEESQIRIEL
QMTLDSKDSD IEQLRSQLQA LHIGLDSSSI GSGPGDAEAD DGFPESRLEG WLSLPVRNNT
KKFGWVKKYV IVSSKKILFY DSEQDKEQSN PYMVLDIDKL FHVRPVTQTD VYRADAKEIP
RIFQILYANE GESKKEQEFP VEPVGEKSNY ICHKGHEFIP TLYHFPTNCE ACMKPLWHMF
KPPPALECRR CHIKCHKDHM DKKEEIIAPC KVYYDISTAK NLLLLANSTE EQQKWVSRLV
KKIPKKPPAP DPFARSSPRT SMKIQQNQSI RRPSRQLAPN KPS
//
