ID A0A2I3HCP1_NOMLE Unreviewed; 1569 AA.
AC A0A2I3HCP1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=ATP binding cassette subfamily C member 8 {ECO:0000313|Ensembl:ENSNLEP00000041409.1};
GN Name=ABCC8 {ECO:0000313|Ensembl:ENSNLEP00000041409.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000041409.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000041409.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000041409.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts with KCNJ11. {ECO:0000256|ARBA:ARBA00011132}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; ADFV01112616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01112617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01112618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01112619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01112620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 61853.ENSNLEP00000041409; -.
DR Ensembl; ENSNLET00000044046.1; ENSNLEP00000041409.1; ENSNLEG00000017729.2.
DR GeneTree; ENSGT00940000156626; -.
DR InParanoid; A0A2I3HCP1; -.
DR OMA; ANTVVLW; -.
DR Proteomes; UP000001073; Chromosome 15.
DR GO; GO:0008282; C:inward rectifying potassium channel; IEA:Ensembl.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0043531; F:ADP binding; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0005267; F:potassium channel activity; IEA:Ensembl.
DR GO; GO:0008281; F:sulfonylurea receptor activity; IEA:InterPro.
DR GO; GO:0044325; F:transmembrane transporter binding; IEA:Ensembl.
DR GO; GO:0061535; P:glutamate secretion, neurotransmission; IEA:Ensembl.
DR GO; GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
DR GO; GO:0050905; P:neuromuscular process; IEA:Ensembl.
DR GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
DR CDD; cd18591; ABC_6TM_SUR1_D1_like; 1.
DR CDD; cd18602; ABC_6TM_SUR1_D2_like; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR000844; ABCC8.
DR InterPro; IPR000388; ABCC8/9.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR PANTHER; PTHR24223:SF187; ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR PRINTS; PR01093; SULFNYLUR1.
DR PRINTS; PR01092; SULFNYLUREAR.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 33..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 988..1009
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1050..1076
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1140..1165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1241..1259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1265..1284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 291..593
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 670..917
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1002..1294
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1332..1566
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 923..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..970
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1569 AA; 175707 MW; 3491413FAFBB9923 CRC64;
MPLAFCGSEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG ECAQRARREL
GTWIPFPRHP NRQYLTHPYP VCFSLPSQVT ESRHLHLYMP AGMAFMAAVT SVVYYHNIET
SNFPKLLIAL LVYWTLAFIT KTIKFVKFSD HAIGFSQLRF CLTGLLVILY GMLLLVEVNV
IRVRRYIFFK TPREVKPPED LQDLGVRFLQ PFVNLLSKGT YWWMNAFIKT AHKKPIDLRA
IGKLPIAMRA LTNYQRLCEA FDAQVRKDVQ GTQGARAIWQ ALSHAFGRRL ILSSTFRILA
DLLGFAGPLC IFGIVDHLGK ENGVFQPKTQ FLGVYFVSSQ EFLANAYVLA VLLFLALLLQ
RTFLQASYYV AIETGINLRG AIQTKIYNKI MHLSTSNLSM GEMTAGQICN LVAIDTNQLM
WFFFLCPNLW AMPVQIIVGV ILLYYILGVS ALIGAAVIIL LAPVQYFVAT KLSQAQRSTL
EYSNERLKQT NEMLRGIKLL KLYAWENIFR TRVETTRRKE MTSLRAFAIY TSISIFMNTA
IPIAAVLITF VGHVSFFKEA DFSPSVAFAS LSLFHILVTP LFLLSSVVRS TVKALVSVQK
LSEFLSSAEI HEEQCAPHEP TPQGPASKYQ AVPLKVVNRK RPAREDCRGL TGPLQSLVPS
ADGDADNCCV QIMGGYFTWT PDGIPTLSNI TIRIPRGQLT MIVGQVGCGK SSLLLAALGE
MQKVSGAVFW SSVPFLPCCS PERETATDLD IRKRGPVAYA SQKPWLLNAT VEENIIFESP
FNKQRYKMVI EACSLQPDID ILPHGDQTQI GERGINLSGG QRQRISVARA LYQHANVVFL
DDPFSALDIH LSDHLMQAGI LELLRDDKRT VVLVTHKLQY LPHADWIIAM KDGTIQREGT
LKDFQRSECQ LFEHWKTLMN RQDQELEKET VTERKATEPP PGLSRAMSSR DGLLQDEEEE
EEEAAESEED DNLSSVLHQR AEIPWRACAK YLSSAGILLL SLLVFSQLLK HMVLVAIDYW
LAKWTDSALT LTPAVRNCSL SQECTLDQTV YAMVFTVLCS LGIVLCLVTS VTVEWTGLKV
AKRLHRSLLN RIILAPMRFF ETTPLGSILN RFSSDCNTID QHIPSTLECL SRSTLLCVSA
LAVISYVTPV FLVALLPLAI VCYFIQKYFR VASRDLQQLD DTTQLPLLSH FAETVEGLTT
IRAFRYEARF QQKLLEYTDS NNIASLFLTA ANRWLEVRME YIGACVVLIA AVTSISNSLH
RELSAGLVGL GLTYALMVSN YLNWMVRNLA DMELQLGAVK RIHGLLKTEA ESYEGLLAPS
LIPKNWPDQG KIQIQNLSVR YDSSLKPVLK HVNALISPGQ KIGICGRTGS GKSSFSLAFF
RMVDTFEGHI IIDGIDIAKL PLHTLRSRLS IILQDPVLFS GTIRFNLDPE RKCSDSTLWE
ALEIAQLKLV VKALPGGLDA IITEGGENFS QGQRQLFCLA RAFVRKTSIF IMDEATASID
MATENILQKV VMTAFADRTV VTIAHRVHTI LSADLVIVLK RGAILEFDKP EKLLSRKDSV
FASFVRADK
//
