ID A0A2I3HE03_NOMLE Unreviewed; 422 AA.
AC A0A2I3HE03;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Zinc finger protein 620 {ECO:0000313|Ensembl:ENSNLEP00000041691.1};
GN Name=ZNF620 {ECO:0000313|Ensembl:ENSNLEP00000041691.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000041691.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000041691.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000041691.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01172442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003256940.1; XM_003256892.3.
DR RefSeq; XP_012351663.1; XM_012496209.1.
DR AlphaFoldDB; A0A2I3HE03; -.
DR Ensembl; ENSNLET00000054400.1; ENSNLEP00000041691.1; ENSNLEG00000005719.3.
DR GeneID; 100579662; -.
DR KEGG; nle:100579662; -.
DR CTD; 253639; -.
DR GeneTree; ENSGT00940000163769; -.
DR OrthoDB; 1383805at2759; -.
DR Proteomes; UP000001073; Chromosome 4.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 8.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23226; ZINC FINGER AND SCAN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23226:SF412; ZINC FINGER PROTEIN 529; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR Pfam; PF13465; zf-H2C2_2; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 11..82
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 196..223
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 224..251
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 252..279
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 280..307
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 308..335
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 336..363
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 364..391
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 392..419
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 422 AA; 48562 MW; 53F270F8BC16A44F CRC64;
MFQTAWRQEP VTFEDVAVYF TQNEWASLDS VQRALYREVM LENYANVASL AFPFTTPVLV
SQLEQGELPW GLDPWEPMGR EAFRGICTGD EARTEKEGLT PKEHVSKETE SFRLMVGELP
GNVSQHLDFG SSLEQPQGHW IIKTKSKRRH FTDTSARHHE AYAVNNGEKF EKLGKTISVS
IQLTTNQTIP SGQISYECGQ CGRYFIRMAD FHRHQKCHTG EKSFECKECG KDFRYNSLLI
RHQIIHTGKK PFKCKECGKG LSSDTALIQH QRIHTGEKPY ECKECSKAFS SSSVFLQHQR
FHTGEKLYEC NECWKTFSCS SSFTVHQRMH TGEKPYECKE CGKRLSSNTA LTQHQRIHTG
EKPFECKECG KAFNQKITLI QHQRVHTGEK PYECKVCGKT FSWCGRFILH QKLHTQKTPV
QA
//
