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Database: UniProt
Entry: A0A2I3HEA9_NOMLE
LinkDB: A0A2I3HEA9_NOMLE
Original site: A0A2I3HEA9_NOMLE 
ID   A0A2I3HEA9_NOMLE        Unreviewed;       420 AA.
AC   A0A2I3HEA9;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   18-SEP-2019, entry version 12.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000041801};
GN   Name=KCNJ6 {ECO:0000313|Ensembl:ENSNLEP00000041801};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000041801, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000041801, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000041801}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; ADFV01019306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01019307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01019308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01019309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01019310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01019311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01019312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01019313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01019314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01019315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSNLET00000056210; ENSNLEP00000041801; ENSNLEG00000004741.
DR   GeneTree; ENSGT00970000193368; -.
DR   Proteomes; UP000001073; Chromosome 25.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015467; F:G-protein activated inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003275; K_chnl_inward-rec_Kir3.2.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF19; PTHR11767:SF19; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01328; KIR32CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     90    114       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    164    188       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       54    193       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      200    369       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      387    420       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    389    420       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   SITE        179    179       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   420 AA;  48160 MW;  031AFE2E5B71D2B0 CRC64;
     QTRSKTNVLE GDSMDQDVES PVAIHQPKLP KQARDDLPRH ISRDRTKRKI QRYVRKDGKC
     NVHHGNVRET YRYLTDIFTT LVDLKWRFNL LIFVMVYTVT WLFFGMIWWL IAYIRGDMDH
     IEDPSWTPCV TNLNGFVSAF LFSIETETTI GYGYRVITDK CPEGIILLLI QSVLGSIVNA
     FMVGCMFVKI SQPKKRAETL VFSTHAVISM RDGKLCLMFR VGDLRNSHIV EASIRAKLIK
     SKQTSEGEFI PLNQTDINVG YYTGDDRLFL VSPLIISHEI NQQSPFWEIS KAQLPKEELE
     IVVILEGMVE ATGMTCQARS SYITSEILWG YRFTPVLTLE DGFYEVDYNS FHETYETSTP
     SLSAKELAEL ASRAELPLSW SVSSKLNQHA ELETEEEEKN LEEQTERNGD VANLENESKV
//
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