ID   A0A2I3HFX1_NOMLE        Unreviewed;       493 AA.
AC   A0A2I3HFX1;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=ADP-ribosylation factor GTPase-activating protein 2 {ECO:0000256|ARBA:ARBA00039244};
DE   AltName: Full=Zinc finger protein 289 {ECO:0000256|ARBA:ARBA00043100};
GN   Name=ARFGAP2 {ECO:0000313|Ensembl:ENSNLEP00000042407.1};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000042407.1, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000042407.1, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000042407.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Golgi
CC       apparatus membrane {ECO:0000256|ARBA:ARBA00004255}; Peripheral membrane
CC       protein {ECO:0000256|ARBA:ARBA00004255}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004255}.
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DR   EMBL; ADFV01115836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003279007.1; XM_003278959.3.
DR   AlphaFoldDB; A0A2I3HFX1; -.
DR   Ensembl; ENSNLET00000049593.1; ENSNLEP00000042407.1; ENSNLEG00000014290.2.
DR   GeneTree; ENSGT00940000155568; -.
DR   Proteomes; UP000001073; Chromosome 15.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   CDD; cd09029; ArfGap_ArfGap2; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   PANTHER; PTHR45686; ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED; 1.
DR   PANTHER; PTHR45686:SF10; ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 2; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00105; ArfGap; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00288}; Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Transport {ECO:0000256|ARBA:ARBA00022448};
KW   Zinc {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00288}.
FT   DOMAIN          11..117
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   REGION          128..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          190..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          368..392
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          243..277
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        141..174
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        373..389
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   493 AA;  53509 MW;  F4D00D0FB4E48BA7 CRC64;
     MAAEPNKTEI QTLFKRLRAV PTNKACFDCG AKNPSWASIT YGVFLCIDCS GVHRSLGVHL
     SFIRSTELDS NWNWFQLRCM QVGGNANATA FFRQHGCTAN DANTKYNSRA AQMYREKIRQ
     LGSAALARHG TDPPAWDAPA TEPSGTQQPA LSTESSGLTQ PEHGPNTDLL GTSPKASLEL
     KSSIIGKKKP AAAKKGLGAK KGLGAQKVSS QSFSEIERQA QVAEKLREQQ AADAKKQAEE
     SMVASMRLAY QELQIDRKKE EKKLQNLEGK KREQAERLGM GLVSRSSVSH SVLSEMQVIE
     QETPVSAKSS RSQLDVFDDV GTFASGPPKY KDNPFSLGES FGSRWDTDAA WGMDRVEEKE
     PEVTISSIRP ISERATNRRE VESRSSGLES SEARQKFAGA KAISSDMFFG REVDAEYEAR
     SRLQQLSGSS AISSSDLFGD MDGAHGAGSV SLGNVLPTAD IAQFKQGVKS VAGKMAVLAN
     GVMNSLQDRY GSY
//