ID A0A2I3HGR2_NOMLE Unreviewed; 548 AA.
AC A0A2I3HGR2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=PWWP domain-containing protein {ECO:0000259|PROSITE:PS50812};
GN Name=HDGFL2 {ECO:0000313|Ensembl:ENSNLEP00000042799.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000042799.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000042799.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000042799.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01099291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01099292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01099293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01099294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01125198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01125199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01125200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01125201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01145445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01145446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3HGR2; -.
DR STRING; 61853.ENSNLEP00000042799; -.
DR Ensembl; ENSNLET00000060017.1; ENSNLEP00000042799.1; ENSNLEG00000013287.3.
DR GeneTree; ENSGT00940000153942; -.
DR InParanoid; A0A2I3HGR2; -.
DR OMA; AEETHNN; -.
DR Proteomes; UP000001073; Chromosome 17.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042692; P:muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0043403; P:skeletal muscle tissue regeneration; IEA:Ensembl.
DR CDD; cd20149; PWWP_HDGFL2; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR036218; HIVI-bd_sf.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR PANTHER; PTHR12550; HEPATOMA-DERIVED GROWTH FACTOR-RELATED; 1.
DR PANTHER; PTHR12550:SF18; HEPATOMA-DERIVED GROWTH FACTOR-RELATED PROTEIN 2; 1.
DR Pfam; PF00855; PWWP; 1.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF140576; HIV integrase-binding domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 7..64
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT REGION 86..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..359
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..505
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..548
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 548 AA; 60723 MW; 4F550A949169ABCB CRC64;
MPHAFKPGDL VFAKMKGYPH WPARIDDIAD GAVKPPPNKY PIFFFGTHET AFLGPKDLFP
YDKCKDKYGK PNKRKGFNEG LWEIQNNPHA SYSAPPPVSS SDSEAPEANP AGGSDADEDD
EDRGVMAVTA VTATAASDRM ESDSDSDKSS DNNGLKRKTP VLKMSVSKRA RKASSDLDQA
SMSPSEEENS ESSSESEKTS DQDFTPEKKA VVRAPRRGPL GGRKKKVAES ERMREREGER
RERERVRGRE KRERERERER EGEARGREKR GEEREVCAGA YISGLCVCVL SLCTCAKKSA
KKLQSSSTEP ARKPGQKEKR ARPEEKPQAK PVKVERTRKR SEGFSMDRKV EKKKEPSVEE
KLQKLHSEIK FALKVDSPDV KRCLNGRCTW VSQASSLGGQ IRRYKANKDV MEKAAEVYTR
LKSRVLGPKI EAVQKANKAG TEKEKAEEKL AGEELAGEEA PQEKAEDKPS TDLSAPVNGE
ATSQKGESAE DKEHEEGRDL EEGPRCVSRA VGFGLLSGSG GPDLDRPGSD RQERERARGD
SEALDEES
//
