ID A0A2I3HHX6_NOMLE Unreviewed; 1255 AA.
AC A0A2I3HHX6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Adhesion G protein-coupled receptor B2 {ECO:0000313|Ensembl:ENSNLEP00000043204.1};
GN Name=ADGRB2 {ECO:0000313|Ensembl:ENSNLEP00000043204.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000043204.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000043204.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000043204.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; ADFV01094556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01094557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01094558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01094559; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01094560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3HHX6; -.
DR Ensembl; ENSNLET00000042278.1; ENSNLEP00000043204.1; ENSNLEG00000002059.3.
DR GeneTree; ENSGT00940000160103; -.
DR Proteomes; UP000001073; Chromosome 12.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR12011:SF41; ADHESION G PROTEIN-COUPLED RECEPTOR B2; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF00090; TSP_1; 3.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 3.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50092; TSP1; 3.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 665..686
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 698..719
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 731..755
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 767..792
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 847..868
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 874..898
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 250..320
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 661..899
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 496..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1048..1073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1112..1143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1185..1255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1255 AA; 137979 MW; F3C524DB019EE1DC CRC64;
SLGVNGLMSE DGPICDERAH RRGGGQLCLG SPQAEGKQDC LHCATVTEPS WPLLSPCRHL
RVPGEEPEEE PKVKTQWPRS ADEPGLYMAQ TVHGVWEEWG SWSLCSRSCG RGSRSRMRTC
VPPQHGGKAC EGPELQTKLC SMAACPVEGQ WLEWGPWGPC STSCANGTQQ RSRKCSVAGP
AWATCTGALT DTRECSNLEC PATDSKWGPW NAWSLCSKTC DTGWQRRFRM CQATGTQGYP
CEGTGEEVKP CSEKRCPAFH EMCRDEYVML MTWKKAAAGE IIYNKCPPNA SGSASRRCLL
SAQGVAYWGL PSFARCISHE YRYLYLSLRE HLAKGQRMLA GEGMSQVVRS LQELLARRTY
YSGDLLFSVD ILRNVTDTFK RATYVPSADD VQRFFQVVSF MVDAENKEKW DDAQQVSPGS
VHLLRVVEDF IHLVGDALKA FQSSLIVTDN LVISIQREPV SAVSSDITFP MRGRRGMKDW
VRHSEDRLFL PKEVLSLSSP GKPATSGAAG SPGRGRGPGT VPPGPGHSHQ RLLPADPDES
SYFVIGAVLY RTLGLILPPP RPPLAVTSRV MTVTVRPPTQ PPAEPLITVE LSYIINGTTD
PRCASWDYSR ADASSGDWDT ENCQTLETQA AHTRCQCQHL STFAVLAQPP KDLTLELAGS
PSVPLVIGCA VSCMALLTLL AIYAAFWRFI KSERSIILLN FCLSILASNI LILVGQSRVL
SKGVCTMTAA FLHFFFLSSF CWVLTEAWQS YLAVIGRMRT RLVRKRFLCL GWGLPALVVA
VSVNMLIGII VFNKLMARDG ISDKSKKQRA GSERCPWASL LLPCSACGAV PSPLLSSASA
RNAMASLWSS CVVLPLLALT WMSAVLAMTD RRSVLFQALF AVFNSAQGFV ITAVHCFLRR
EVQDVVKCQM GVCRADESED SPDSCKNGQL QILSDFEKDV DLACQTGDSV KEVNTCKPVH
HHGHAIPLSW MRMRSPSLAR QLSFSPLPGN ILVPMAASPG LGEPPPPQEA NPVYMCGEGG
LRQLDLTWLR PAEPGSEGDY MVLPRRTLSL QPGGGGGGGE DAPRARPEGT PRRAAKTVAH
TEGYPSFLSV DHSGLGLGPA YGSLQNPYGM TFQPPPPTPS ARQVPEPGER SRTMPRTVPG
STMKMGSLER KKLRYSDLDF EKVMHTRKRH SELYHELNQK FHTFDRYRSQ STAKDKPSPG
ERPSLSQHRR HQSWSTFKSM TLGSLPPKPR ERLTLHRAAA WEPTEPPDGD FQTEV
//