GenomeNet

Database: UniProt
Entry: A0A2I3HHX6_NOMLE
LinkDB: A0A2I3HHX6_NOMLE
Original site: A0A2I3HHX6_NOMLE 
ID   A0A2I3HHX6_NOMLE        Unreviewed;      1255 AA.
AC   A0A2I3HHX6;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=Adhesion G protein-coupled receptor B2 {ECO:0000313|Ensembl:ENSNLEP00000043204.1};
GN   Name=ADGRB2 {ECO:0000313|Ensembl:ENSNLEP00000043204.1};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000043204.1, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000043204.1, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000043204.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ADFV01094556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01094557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01094558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01094559; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01094560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2I3HHX6; -.
DR   Ensembl; ENSNLET00000042278.1; ENSNLEP00000043204.1; ENSNLEG00000002059.3.
DR   GeneTree; ENSGT00940000160103; -.
DR   Proteomes; UP000001073; Chromosome 12.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR   Gene3D; 1.25.40.610; -; 1.
DR   Gene3D; 2.60.220.50; -; 1.
DR   Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR   InterPro; IPR032471; GAIN_dom_N.
DR   InterPro; IPR046338; GAIN_dom_sf.
DR   InterPro; IPR017981; GPCR_2-like_7TM.
DR   InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR   InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR000203; GPS.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   PANTHER; PTHR12011:SF41; ADHESION G PROTEIN-COUPLED RECEPTOR B2; 1.
DR   PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF16489; GAIN; 1.
DR   Pfam; PF01825; GPS; 1.
DR   Pfam; PF02793; HRM; 1.
DR   Pfam; PF00090; TSP_1; 3.
DR   PRINTS; PR01694; BAIPRECURSOR.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   SMART; SM00303; GPS; 1.
DR   SMART; SM00008; HormR; 1.
DR   SMART; SM00209; TSP1; 3.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR   PROSITE; PS50221; GPS; 1.
DR   PROSITE; PS50092; TSP1; 3.
PE   4: Predicted;
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        665..686
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        698..719
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        731..755
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        767..792
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        847..868
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        874..898
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          250..320
FT                   /note="G-protein coupled receptors family 2 profile 1"
FT                   /evidence="ECO:0000259|PROSITE:PS50227"
FT   DOMAIN          661..899
FT                   /note="G-protein coupled receptors family 2 profile 2"
FT                   /evidence="ECO:0000259|PROSITE:PS50261"
FT   REGION          496..535
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1048..1073
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1112..1143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1185..1255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1255 AA;  137979 MW;  F3C524DB019EE1DC CRC64;
     SLGVNGLMSE DGPICDERAH RRGGGQLCLG SPQAEGKQDC LHCATVTEPS WPLLSPCRHL
     RVPGEEPEEE PKVKTQWPRS ADEPGLYMAQ TVHGVWEEWG SWSLCSRSCG RGSRSRMRTC
     VPPQHGGKAC EGPELQTKLC SMAACPVEGQ WLEWGPWGPC STSCANGTQQ RSRKCSVAGP
     AWATCTGALT DTRECSNLEC PATDSKWGPW NAWSLCSKTC DTGWQRRFRM CQATGTQGYP
     CEGTGEEVKP CSEKRCPAFH EMCRDEYVML MTWKKAAAGE IIYNKCPPNA SGSASRRCLL
     SAQGVAYWGL PSFARCISHE YRYLYLSLRE HLAKGQRMLA GEGMSQVVRS LQELLARRTY
     YSGDLLFSVD ILRNVTDTFK RATYVPSADD VQRFFQVVSF MVDAENKEKW DDAQQVSPGS
     VHLLRVVEDF IHLVGDALKA FQSSLIVTDN LVISIQREPV SAVSSDITFP MRGRRGMKDW
     VRHSEDRLFL PKEVLSLSSP GKPATSGAAG SPGRGRGPGT VPPGPGHSHQ RLLPADPDES
     SYFVIGAVLY RTLGLILPPP RPPLAVTSRV MTVTVRPPTQ PPAEPLITVE LSYIINGTTD
     PRCASWDYSR ADASSGDWDT ENCQTLETQA AHTRCQCQHL STFAVLAQPP KDLTLELAGS
     PSVPLVIGCA VSCMALLTLL AIYAAFWRFI KSERSIILLN FCLSILASNI LILVGQSRVL
     SKGVCTMTAA FLHFFFLSSF CWVLTEAWQS YLAVIGRMRT RLVRKRFLCL GWGLPALVVA
     VSVNMLIGII VFNKLMARDG ISDKSKKQRA GSERCPWASL LLPCSACGAV PSPLLSSASA
     RNAMASLWSS CVVLPLLALT WMSAVLAMTD RRSVLFQALF AVFNSAQGFV ITAVHCFLRR
     EVQDVVKCQM GVCRADESED SPDSCKNGQL QILSDFEKDV DLACQTGDSV KEVNTCKPVH
     HHGHAIPLSW MRMRSPSLAR QLSFSPLPGN ILVPMAASPG LGEPPPPQEA NPVYMCGEGG
     LRQLDLTWLR PAEPGSEGDY MVLPRRTLSL QPGGGGGGGE DAPRARPEGT PRRAAKTVAH
     TEGYPSFLSV DHSGLGLGPA YGSLQNPYGM TFQPPPPTPS ARQVPEPGER SRTMPRTVPG
     STMKMGSLER KKLRYSDLDF EKVMHTRKRH SELYHELNQK FHTFDRYRSQ STAKDKPSPG
     ERPSLSQHRR HQSWSTFKSM TLGSLPPKPR ERLTLHRAAA WEPTEPPDGD FQTEV
//
DBGET integrated database retrieval system