ID A0A2I3HI54_NOMLE Unreviewed; 510 AA.
AC A0A2I3HI54;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Amiloride-sensitive sodium channel subunit beta {ECO:0000256|ARBA:ARBA00039757};
DE AltName: Full=Beta-NaCH {ECO:0000256|ARBA:ARBA00043222};
DE AltName: Full=Epithelial Na(+) channel subunit beta {ECO:0000256|ARBA:ARBA00042602};
DE AltName: Full=Nonvoltage-gated sodium channel 1 subunit beta {ECO:0000256|ARBA:ARBA00042734};
DE AltName: Full=SCNEB {ECO:0000256|ARBA:ARBA00041932};
GN Name=SCNN1B {ECO:0000313|Ensembl:ENSNLEP00000043146.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000043146.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000043146.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000043146.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR EMBL; ADFV01197248; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197249; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197250; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197251; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197252; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197253; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3HI54; -.
DR Ensembl; ENSNLET00000038634.1; ENSNLEP00000043146.1; ENSNLEG00000012065.2.
DR GeneTree; ENSGT00940000160893; -.
DR Proteomes; UP000001073; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690:SF18; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT BETA; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 2.
DR PRINTS; PR01078; AMINACHANNEL.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022480};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679}; Taste {ECO:0000256|ARBA:ARBA00022480};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|RuleBase:RU000679}.
FT REGION 462..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 510 AA; 57394 MW; 1D7C58487961595E CRC64;
DFPAVTICNA SPFKYSKIKH LLKDLDELME AVLERILAPE LGHRTPNSSI WNHTPLVLID
ERNPHHPVVL DLFGDNHNGL TSSSASEKIC NAQGCKMAMR LCSLNGTQCT FRNFTSATQA
VTEWYFLQAT NIFAQVPQQE LVEMSHPGEQ MILACLFGAE PCNYRNFTSI FYPHYGNCYI
FNWGMTEKAL PSANPGTEFG LKLILDIGQE DYVPFLTSTA GVRLMLHEQR SYPFIRDEGI
YAMSGTETSI GVLVACLRSC FQDHMIHNCN CGHYLYPLPR GEKYCNNRDF PDWAHCYSDL
QMSVAQRETC IGMCKESCND TQYKMTISMA DWPSEASEDW IFHVLSQERD QSTNITLSRK
GIVKLNIYFQ EFNYRTIEES AANNIVWLLS NLGGQFGFWM GGSVLCLIEF GEIIIDFVWI
TIIKLVALAK SLRQRRAQAS YAGPPPTVAE LVEAHTNFGF QPDTAPRIPN TGPYPSEQAL
PIPGTPPPNY DSLRLQPLDV IESDSEGDAI
//
