ID A0A2I3HJ37_NOMLE Unreviewed; 574 AA.
AC A0A2I3HJ37;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=CD166 antigen {ECO:0000256|ARBA:ARBA00015291};
DE AltName: Full=Activated leukocyte cell adhesion molecule {ECO:0000256|ARBA:ARBA00030009};
GN Name=ALCAM {ECO:0000313|Ensembl:ENSNLEP00000043634.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000043634.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000043634.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000043634.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Cell projection,
CC dendrite {ECO:0000256|ARBA:ARBA00004279}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; ADFV01005893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01005894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01005895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01005896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3HJ37; -.
DR Ensembl; ENSNLET00000050964.1; ENSNLEP00000043634.1; ENSNLEG00000003402.3.
DR GeneTree; ENSGT00940000156881; -.
DR Proteomes; UP000001073; Chromosome 21.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00096; Ig; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR11973:SF2; CD166 ANTIGEN; 1.
DR PANTHER; PTHR11973; CELL SURFACE GLYCOPROTEIN MUC18-RELATED; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 519..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 129..238
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 249..332
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 351..413
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 420..505
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 574 AA; 64429 MW; C0D081786A7254AF CRC64;
MHLEVICHFK KTFKILFSLS LFFPPRPKGL GWYTVNSAYG DTIIMPCRLD VPQNLMFGKW
KYEKPDGSPV FIAFRSSTKK SVQYDDVPEY KDRLSLSENY TLSISNARIS DEKRFVCMLV
TEDNVFEAPT IVKVFKQPSK PEIVSKALFL ETEQLKKLGD CISEDSYPDG NITWYRNGKV
LHPLEGAVVI IFKKEMDPVT QLYTMTSTLE YKTTKADIQM PFTCSVTYYG PSGQKTIHSE
RAVFDIYYPT EQVTIQVLPP KNAIKEGDNI TLKCLGNGNP PPEEFLFYLP GQPEGIRSSN
TYTLTDVRRN ATGDYKCSLI DKKSMIASTA ITVHYLDLSL NPSGEVTRQI GDALPVSCTI
SASRNATVVW MKDNIRLRSS PSFSSLHYQD AGNYVCETAL QEVEGLKKRE SLTLIVEGKP
QIKMTKKTDP SGLSKTIICH VEGFPKPAIQ WTITGSGSVI NQTEESPYIN GRYYSKIIIS
PEENVTLTCT AENQLERTVN SLNVSANENR EKVNDQAKLI VGIVVGLLLA ALVAGVVYWL
YMKKSKAASK HVNKDLGNME ENKKLEENNH KTEA
//
