ID A0A2I3HJ77_NOMLE Unreviewed; 1939 AA.
AC A0A2I3HJ77;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN Name=SCN2A {ECO:0000313|Ensembl:ENSNLEP00000043562.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000043562.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000043562.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000043562.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; ADFV01031957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01031958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01031959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01031960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 61853.ENSNLEP00000043562; -.
DR Ensembl; ENSNLET00000051301.1; ENSNLEP00000043562.1; ENSNLEG00000003112.2.
DR GeneTree; ENSGT00940000154224; -.
DR InParanoid; A0A2I3HJ77; -.
DR OMA; ISVIPXH; -.
DR Proteomes; UP000001073; Chromosome 17.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0014704; C:intercalated disc; IEA:Ensembl.
DR GO; GO:0033270; C:paranode region of axon; IEA:Ensembl.
DR GO; GO:0042734; C:presynaptic membrane; IEA:Ensembl.
DR GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR GO; GO:0021542; P:dentate gyrus development; IEA:Ensembl.
DR GO; GO:0008340; P:determination of adult lifespan; IEA:Ensembl.
DR GO; GO:0008627; P:intrinsic apoptotic signaling pathway in response to osmotic stress; IEA:Ensembl.
DR GO; GO:0007613; P:memory; IEA:Ensembl.
DR GO; GO:0021675; P:nerve development; IEA:Ensembl.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF278; SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 5.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SMART; SM00015; IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 383..410
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 733..757
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 769..790
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 860..885
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 935..957
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1183..1201
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1222..1244
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1250..1270
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1299..1325
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1423..1447
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1505..1523
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1535..1562
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1583..1611
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1687..1710
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 133..416
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 540..691
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 741..964
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 971..1177
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1181..1456
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1504..1551
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1555..1720
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 28..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1094..1139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1869..1939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 407..452
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 28..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..511
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1869..1893
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1894..1911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1912..1939
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1939 AA; 220634 MW; 399C0C2FB64A5B57 CRC64;
MAQSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKAKRPKQE RKDEDDENGP KPNSDLEAGK
SLPFIYGDIP PEMVSVPLED LDPYYINKKT FIVLNKGKAI SRFSATPALY ILTPFNPIRK
LAIKILVHSY PFSNPWLFSL RYTFTGIYTF ESLIKILARG FCLEDFTFLR DPWNWLDFTV
ITFAYVTEFV DLGNVSALRT FRVLRALKTI SVIPGLKTIV GALIQSVKKL SDVMILTVFC
LSVFALIGLQ LFMGNLRNKC LQWPPDNSSF EINITSFFNN SLDGNGTTFN RTVSMFNWDE
YIEDKSHFYF LEGQNDALLC GNSSDAGQCP EGYICVKAGR NPNYGYTSFD TFSWAFLSLF
RLMTQDFWEN LYQLTLRAAG KTYMIFFVLV IFLGSFYLIN LILAVVAMAY EEQNQATLEE
AEQKEAEFQQ MLEQLKKQQE EAQAAAAAAS AESRDFSGAG GIGVFSESSS VASKLSSKSE
KELKNRRKKK KQKEQSGEEE KNDRVRKSES EDSIRRKGFR FSLEGSRLTY EKRFSSPHQS
LLSIRGSLFS PRRNSRASLF SFRGRAKDIG SENDFADDEH STFEDNDSRR DSLFVPHRHG
ERRHSNVSQA SRASRVLPIL PMNGKMHSAV DCNGVVSLVG GPSTLTSAGQ LLPEGTTTET
EIRKRRSSSY HVSMDLLEDP TSRQRAMSIA SILTNTMEEL EESRQKCPPC WYKFANMCLI
WDCCKPWLKV KHLVNLVVMD PFVDLAITIC IVLNTLFMAM EHYPMTEQFS SVLSVGNLVF
TGIFTAEMFL KIIAMDPYYY FQEGWNIFDG FIVSLSLMEL DLANVEGLPS LRSFRLLRVF
KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV GMQLFGKSYK ECVCKISNDC
ELPRWHMHDF FHSFLIVFRV LCGEWIETMW DCMEVNVLIT CFPTVFQVLN LFLALLLSSF
SSDNLAATDD DNEMNNLQIA VGRMQKGIDF VKRKIREFIQ KAFVRKQKAL DEIKPLEDLN
NKKDSCISNH TTIEIGKDLN YLKDGNGTTS GIGSSVEKYV VDESDYMSFI NNPSLTVTVP
IAVGESDFEN LNTEEFSSES DMEESKEKLN ATSSSEGSTV DIGAPAEGEQ PEVEPEESLE
PEACFTEDCV RKFKCCQISI EEGKGKLWWN LRKTCYKIVE HNWFETFIVF MILLSSGALA
FEDIYIEQRK TIKTMLEYAD KVFTYIFILE MLLKWVAYGF QVYFTNAWCW LDFLIVDVSL
VSLTANALGY SELGAIKSLR TLRALRPLRA LSRFEGMRVV VNALLGAIPS IMNVLLVCLI
FWLIFSIMGV NLFAGKFYHC INYTTGEMFD VSVVNNYSEC KALIESNQTA RWKNVKVNFD
NVGLGYLSLL QVATFKGWMD IMYAAVDSRN VELQPKYEDN LYMYLYFVIF IIFGSFFTLN
LFIGVIIDNF NQQKKKISQD IFMTEEQKKY YNAMKKLGSK KPQKPIPRPA NKFQGMVFDF
VTKQVFDISI MILICLNMVT MMVETDDQSQ EMTNILYWIN LVFIVLFTGE CYFVSPTLFR
VIRLARIGRI LRLIKGAKGI RTLLFALMMS LPALFNIGLL LFLVMFIYAI FGMSNFAYVK
REVGIDDMFN FETFGNSMIC LFQITTSAGW DGLLAPILNS GPPDCDPEKD HPGSSVKGDC
GNPSVGIFFF VSYIIISFLV VVNMYIAVIL ENFSVATEES AEPLSEDDFE MFYEVWEKFD
PDATQFIEFA KLSDFADALD PPLLIAKPNK VQLIAMDLPM VSGDRIHCLD ILFAFTKRVL
GESGEMDALR IQMEERFMAS NPSKVSYEPI TTTLKRKQEE VSAIIIQRAY RRYLLKQKVK
KVSSIYKKDK GKECDGTPIK EDTLIDKLNE NSTPEKTDMT PSTTSPPSYD SVTKPEKEKF
EKDKSEKEDK GKDIRESKK
//
