ID A0A2I3HJM8_NOMLE Unreviewed; 383 AA.
AC A0A2I3HJM8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Delta like non-canonical Notch ligand 2 {ECO:0000313|Ensembl:ENSNLEP00000043824.1};
GN Name=DLK2 {ECO:0000313|Ensembl:ENSNLEP00000043824.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000043824.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000043824.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000043824.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; ADFV01032238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003266283.1; XM_003266235.2.
DR AlphaFoldDB; A0A2I3HJM8; -.
DR Ensembl; ENSNLET00000057360.1; ENSNLEP00000043824.1; ENSNLEG00000030265.1.
DR GeneID; 100596983; -.
DR KEGG; nle:100596983; -.
DR CTD; 65989; -.
DR GeneTree; ENSGT00940000160761; -.
DR InParanoid; A0A2I3HJM8; -.
DR OMA; SVPEPTW; -.
DR OrthoDB; 5475408at2759; -.
DR Proteomes; UP000001073; Chromosome 17.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0045598; P:regulation of fat cell differentiation; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 4.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF19; PROTEIN CRUMBS HOMOLOG 2; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF00008; EGF; 4.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..383
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014115787"
FT TRANSMEM 307..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..58
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 91..129
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 131..172
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 174..210
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 212..248
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 48..57
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 119..128
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 162..171
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 200..209
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 238..247
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 383 AA; 40507 MW; 60BB67CB8BD64EA7 CRC64;
MPSGCRCLHL VCLLCILGAP GQPVRADDCS SHCDLAHGCC APDGSCRCDP GWEGLHCERC
VRMPGCQHGT CHQPWQCICH SGWAGKFCDK DEHICTTQSP CQNGGQCMYD GGGEYHCVCL
PGFHGRDCER KAGPCEQAGS PCRNGGQCQD DQGFALNFTC RCLVGFVGAR CEVNVDDCLM
RPCANGATCL DGINRFSCLC PEGFAGRFCT INLDDCASRP CQRGARCRDR VHDFDCVCPS
GYGGKTCELV LPVPDPPTTV DTPLGPTSAV MVPATGPAPH SAGAGLLRIS VKEVVRRQEA
GLGEPSLVAL VVFGALTAAL VLATVLLTLR AWRRGVCPPG PCCYPAPHYA PACQDQECQV
SMLPAGLPLP PDLPPEPGKT TAL
//
