ID A0A2I3HJT5_NOMLE Unreviewed; 2097 AA.
AC A0A2I3HJT5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN Name=CACNA1D {ECO:0000313|Ensembl:ENSNLEP00000043767.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000043767.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000043767.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000043767.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. CACNA1D subfamily. {ECO:0000256|ARBA:ARBA00010354}.
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DR EMBL; ADFV01173522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173526; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173529; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000058888.1; ENSNLEP00000043767.1; ENSNLEG00000007223.3.
DR GeneTree; ENSGT00940000154839; -.
DR Proteomes; UP000001073; Chromosome 4.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031688; CAC1F_C.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR005452; LVDCC_a1dsu.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005446; VDCC_L_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF11; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16885; CAC1F_C; 3.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01630; LVDCCALPHA1.
DR PRINTS; PR01636; LVDCCALPHA1D.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|PIRSR:PIRSR602077-3};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..2097
FT /note="Voltage-dependent L-type calcium channel subunit
FT alpha"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014169852"
FT TRANSMEM 98..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 612..631
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 684..711
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 846..864
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 884..904
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 916..942
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 962..992
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1074..1099
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1153..1171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1183..1203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1288..1306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1380..1403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1537..1571
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 26..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 725..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1623..1737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1823..1857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2044..2088
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..747
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..781
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..797
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1636..1651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1676..1705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1721..1737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1823..1844
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 325
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 664
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT CARBOHYD 290
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-3"
SQ SEQUENCE 2097 AA; 237407 MW; 5E965C564E7688ED CRC64;
SIFFLLCFLV APMSTLHMSD ATVKDTKRGP LSVENPGLQG TEGMEGVSGR GGLLAEYKPE
SLPKALGHMG GRAKQRSDPY LAASSLCSPF DSNVDSNLCS FFCLLFLPCP YFFGMFLCFS
SQEKVEYAFL IIFTVETFLK IIAYGLLLHP NAYVRNGWNL LDFVIVIVGL FSVILEQLTK
ETEGGNHSSG KSGGFDVKAL RAFRVLRPLR LVSGVPSLQV VLNSIIKAMV PLLHIALLVL
FVIIIYAIIG LELFIGKMHK TCFFADSDIV AEEDPAPCAF SGNGRQCTAN GTECRSGWVG
PNGGITNFDN FAFAMLTVFQ CITMEGWTDV LYWMNDAMGF ELPWVYFVSL VIFGSFFVLN
LVLGVLSGEF SKEREKAKAR GDFQKLREKQ QLEEDLKGYL DWITQAEDID PENEEEGGEE
GKRNTSMPTS ETESVNTENV SGDARTECGE HFQAISKSKL SRRWRRWNRF NRRRCRAAVK
SVTFYWLVIV LVFLNTLTIS SEHYDQPDWL TQIQDIANKV LLALFTCEML VKMYSLGLQA
YFVSLFNRFD CFVVCGGITE TILVELEIMS PLGISVFRCV RLLRIFKVTR HWTSLSNLVA
SLLNSMKSIA SLLLLLFLFI IIFSLLGMQL FGGKFNFDET QTKRSTFDNF PQALLTVFQI
LTGEDWNAVM YDGIMAYGGP SSSGMIVCIY FIILFICGNY ILLNVFLAIA VDNLADAESL
NTAQKEEAEE KERKKIARKE SLENKKNNKP EVNQIANSDN KVTIDDYREE DEDKDPYPPC
DVPVGEEEEE EEEDEPEVPA GPRPRRISEL NMKEKIAPIP EGSAFFILSK TNPIRVGCHK
LINHHIFTNL ILVFIMLSSA ALAAEDPIRS HSFRNTMLGY ADYVFTGTFA FEIILKMTTF
GAFLHKGAFC RNYFNLLDML VVGVSLVSFG IQSSAISVVK ILRVLRVLRP LRAINRAKGL
KHVVQCVFVA IRTIGNIMIV TTLLQFMFAC IGVQLFKGKF YRCTDEAKSN PEELLKRGVL
EREDLGRQRA GPCGLGGLGR SSLGFSLSRL LYKAIDSNGE NIGPIYNHRV EISIFFIIYI
IIVAFFMMNI FVGFVIVTFQ EQGEKEYKNC ELDKNQRQCV EYALKARPLR RYIPKNPYQY
KFWYVVNSSP FEYMMFVLIM LNTLCLAMQH YEQSKMFNDA MDILNMVFTG VFTVEMVLKV
IAFKPKGYFS DAWNTFDSLI VIGSIIDVAL SEADVSMHLA WPPPNSEESN RISITFFRLF
RVMRLVKLLS RGEGIRTLLW TFIKSFQALP YVALLIAMLF FIYAVIGMQM FGKVAMRDNN
QINRNNNFQT FPQAVLLLFR CATGEAWQEI MLACLPGKLC DPESDYNPGE EYTCGSNFAI
VYFISFYMLC AFLIINLFVA VIMDNFDYLT RDWSILGPHH LDEFKRIWSE YDPEAKGRIK
HLDVVTLLRR IQPPLGFGKL CPHRVACKRL VAMNMPLNSD GTVMFNATLF ALVRTALKIK
TEGNLEQANE ELRAVIKKIW KKTSMKLLDQ VVPPAGDDEV TVGKFYATFL IQDYFRKFKK
RKEQGLVGKY PAKNTTIALQ AGLRTLHDIG PEIRRAISCD LQDDEPEETK REEEDDVFKR
NGALLGNHVN HVNSDRRDSL QQTNTTHRPL HVQRPSIPPA SDTEKPLFPP AGNSVCHNHH
NHNSIGKQVP TSTNANLNNA NMSKAAHGKR PSIGNLEHVS ENGHHSSHKP DRGASEKVQT
RYYETYIRSD SGDEQLPTIC REDPEIHGYF RDPRCLGEQE YFSSEECYED DSSPTWSRQN
YGYYSRYPGR NIDFERPQGY HHPQGFLEDD DSPVCYDSRR SPRRRLLPPT PASHRRSSFN
FECLRRQSSQ EEVPLSPTFP HRTALPLHLM QQQIMAVAGL DSSKAQKYSP SHSTRSWATP
PATPPYRDWT PCYTPLIQVE QSEALDQVNG SLPSLHRSSW YTDEPDISYR TFTPASLTVP
SSFRNKNSDK QRSADSLVEA VLISEGLGRY ARDPKFVSAT KHEIADACDL TIDEMESAAS
TLLNGNVHPR ANGDVGPLSH RQDYELQDFG PGYSDEEPDP GRDEEDLADE MICITTL
//
