ID   A0A2I3HM57_NOMLE        Unreviewed;       845 AA.
AC   A0A2I3HM57;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=dipeptidyl-peptidase IV {ECO:0000256|ARBA:ARBA00012062};
DE            EC=3.4.14.5 {ECO:0000256|ARBA:ARBA00012062};
GN   Name=DPP8 {ECO:0000313|Ensembl:ENSNLEP00000044531.1};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000044531.1, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000044531.1, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000044531.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a
CC         polypeptide, preferentially when Yaa is Pro, provided Zaa is neither
CC         Pro nor hydroxyproline.; EC=3.4.14.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00001257};
CC   -!- SIMILARITY: Belongs to the peptidase S9B family. DPPIV subfamily.
CC       {ECO:0000256|ARBA:ARBA00010036}.
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DR   EMBL; ADFV01035801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01035802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01035803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01035804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01035805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01035806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01035807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01035808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01035809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01035810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2I3HM57; -.
DR   Ensembl; ENSNLET00000033494.1; ENSNLEP00000044531.1; ENSNLEG00000012689.3.
DR   GeneTree; ENSGT00940000160717; -.
DR   Proteomes; UP000001073; Chromosome 6.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR045785; Dpp_8/9_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002469; Peptidase_S9B_N.
DR   PANTHER; PTHR11731:SF98; DIPEPTIDYL PEPTIDASE 8; 1.
DR   PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR   Pfam; PF19520; Dpp_8_9_N; 1.
DR   Pfam; PF00930; DPPIV_N; 2.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT   DOMAIN          1..146
FT                   /note="Dipeptidyl peptidase 8 /9 ,N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19520"
FT   DOMAIN          160..235
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          247..541
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          634..837
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   845 AA;  97123 MW;  B36D5DA813FE6B9D CRC64;
     MAAAMETEQL GVEIFETADC EENIESQDRP KLEPFYVERY SWSQLKKLLA DTRKYHGYMM
     AKAPHDFMFV KRNDPDGPHS DRIYYLAMSG ENRENTLFYS EIPKTINRAA VLMLSWKPLL
     DLFQATLDYG MYSREEELLR ERKRIGTVGI ASYDYHQGSG TFLFQAGSGI YHVKDGGPQG
     FTQQPLRPNL VETSCPNIRM DPKLCPADPD WIAFIHSNDI WISNIVTREE RRLTYVHNAP
     SGGKILRILY EENDESEVEI IHVTSPMLET RRADSFRYPK TGTANPKVTF KMSEIMIDAE
     GRIIDVIDKE LIQPFEILFE GVEYIARAGW TPEGKYAWSI LLDRSQTRLQ IVLISPELFI
     PVEDDVMERQ RLIESVPDSV TPLIIYEETT DIWINIHDIF HVFPQSHEEE IEFIFASECK
     TGFRHLYKIT SILKESKYKR SSGGLPAPSD FKCPIKEEIA ITSGEWEVLG RHGSNIQVDE
     VRRLVYFEGT KDSPLEHHLY VVSYINPGEV TRLTDRGYSH SCCISQHCDF FISKYSNQKN
     PHCVSLYKLS SPEDDPTCKT KEFWATILDS AGPLPDYTPP EIFSFESTTG FTLYGMLYKP
     HDLQPGKKYP TVLFIYGGPQ VQLVNNRFKG VKYFRLNTLA SLGYVVVVID NRGSCHRGLK
     FEGAFKYKMG QIEIDDQVEG LQYLASRYDF IDLDRVGIHG WSYGGYLSLM ALMQRSDIFR
     VAIAGAPVTL WIFYDTGYTE RYMGHPDQNE QGYYLGSVAM QAEKFPSEPN RLLLLHGFLD
     ENVHFAHTSI LLSFLVRAGK PYDLQIYPQE RHSIRVPESG EHYELHLLHY LQENLGSRIA
     ALKVI
//