ID A0A2I3HMQ0_NOMLE Unreviewed; 439 AA.
AC A0A2I3HMQ0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Target of myb1 like 2 membrane trafficking protein {ECO:0000313|Ensembl:ENSNLEP00000044899.1};
GN Name=TOM1L2 {ECO:0000313|Ensembl:ENSNLEP00000044899.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000044899.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000044899.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000044899.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TOM1 family. {ECO:0000256|ARBA:ARBA00007708,
CC ECO:0000256|PIRNR:PIRNR036948}.
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DR EMBL; ADFV01121186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01121187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01121188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01121189; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3HMQ0; -.
DR Ensembl; ENSNLET00000059379.1; ENSNLEP00000044899.1; ENSNLEG00000013722.3.
DR GeneTree; ENSGT00940000156940; -.
DR Proteomes; UP000001073; Chromosome 14.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR CDD; cd14238; GAT_TM1L2; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 2.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR014645; TOM1.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR13856:SF31; TOM1-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR13856; VHS DOMAIN CONTAINING PROTEIN FAMILY; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR PIRSF; PIRSF036948; TOM1; 2.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 2.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR036948};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR036948}.
FT DOMAIN 2..54
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 55..84
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 151..239
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT REGION 93..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 48029 MW; 9C537D0DFCEB0572 CRC64;
KATDGSLQSE DWTLNMEICD IINETEEGPK DAIRALKKRL NGNRNYREVM LALTAWADAF
RSSPDLTGVV HIYEELKRKG VEFPMADLDA LSPIHTPQRS VPEVDPAATM PRSQSQQRTS
AGSYSSPPPA PYSAPQAPAL SVTGPITANS EQIARLRSEL DVVRGNTKVM SEMLTEMVPG
QEDSSDLELL QELNRTCRAM QQRIVELISR VSNEEVTEEL LHVNDDLNNV FLRYERFERY
RSGRSVQNAS NGVLNEVTED NLIDLGPGSP AVVSPMVGNT APPSSLSSQL AGLDLGTESV
SGTLSSLQQC IPRDGFDMFA QTRGNSLAEQ RKMVTYEDPQ AVGGLASALD NRKQSSEGIP
VAQPSVMDDI EVWLRTDLKG DDLEEGVTSE EFDKFLEERA KAAEMVPDLP SPPMEAPAPA
SNPSGRKKPE RSEDALFAL
//
