ID A0A2I3HMR4_NOMLE Unreviewed; 800 AA.
AC A0A2I3HMR4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Adhesion G protein-coupled receptor E1 {ECO:0000313|Ensembl:ENSNLEP00000044943.1};
GN Name=ADGRE1 {ECO:0000313|Ensembl:ENSNLEP00000044943.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000044943.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000044943.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000044943.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01133670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01133671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01133672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01133673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01133674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01133675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01133676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01133677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01133678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01133679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3HMR4; -.
DR Ensembl; ENSNLET00000054702.1; ENSNLEP00000044943.1; ENSNLEG00000000380.2.
DR GeneTree; ENSGT00940000161354; -.
DR Proteomes; UP000001073; Chromosome 10.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR001740; GPCR_2_EMR1-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR12011:SF449; ADHESION G PROTEIN-COUPLED RECEPTOR E1; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF07645; EGF_CA; 6.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR01128; EMR1HORMONER.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 6.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023040};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 585..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 627..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 665..690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 710..732
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 738..761
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..47
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 59..97
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 111..150
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 151..188
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 200..235
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 247..284
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 576..762
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 776..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 204..214
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 800 AA; 87988 MW; 06F0DAED00AF25F7 CRC64;
MRGFNLLLFW GNNCRDSTMC PAYATCTNTV DSYYCTCKQG FLSSNGQNHF KGPGVQCKDI
DECSQSPQPC GPNSSCKNLS GRFKCSCLDG FSSPTGNNWV PGKPGNFSCT DINECLTGRV
CPEHSDCVNS MGSYNCSCQV GFISRNSICE DVDECADPRA CPEHATCNNT VGNYSCFCNP
GFESSSGHLS FQGLKASCED IDECTEMCPI NSTCTNTPGS YFCTCHPGFA PSNGQLNFTD
QEVECRDIDE CRQDPSTCGP NSICTNALGS YNCGCIAGFH PNPEGSQNDG NFSCQRVLFK
CKEDVISDNE QVQQCQEGTA VKPAYVSFCA QINNILSILD KVCENKTTVV SLKNTAESFV
PVLKQISTWT KFTKEETSSL ATVFLESVES MTLASFWKPS ANVTLAVRTE YLDIESKVIN
KECSEENVTL NLVAKGDKMK IGCSTIEESE STGTTGVAFV SFVGMESVLN ERFFQDHQAP
LTTSEIKLKM NSRVTGGIMT GEKKDGFSDP VIYTLENIQP KQKFERPICV SWSTDVEGGR
WTSFGCVILE ASETYTVCSC NRMANLAVIM ASGELTTGCA IIAGFLHYLF LACFFWMLVE
AVILFLMVRN LKVVNYFSSR NIKMLHICAF GYGLPVLLVV ISASVQPQGY GMHNRCWLNT
ETGFIWSFLG PVCAVIVINS ILLTWTLWIL RQRLSSVNAE VSTLKDTRLL TFKAFAQLFI
LGCSWVLGIF QIGPVAGVMA YLFTIINSLQ GAFIFLIHCL LNHQVREEYK RWTIGKTKPS
SQSQTSRILL SSMPSTSKMG
//
