ID A0A2I3HMU7_NOMLE Unreviewed; 897 AA.
AC A0A2I3HMU7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Carnosine synthase 1 {ECO:0000313|Ensembl:ENSNLEP00000044771.1};
GN Name=CARNS1 {ECO:0000313|Ensembl:ENSNLEP00000044771.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000044771.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000044771.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000044771.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01079914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01079915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01079916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01079917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000056676.1; ENSNLEP00000044771.1; ENSNLEG00000006317.3.
DR GeneTree; ENSGT00390000018717; -.
DR Proteomes; UP000001073; Chromosome 4.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0047730; F:carnosine synthase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0035499; P:carnosine biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR041472; BL00235/CARNS1_N.
DR InterPro; IPR031046; CARNS1.
DR PANTHER; PTHR48066; CARNOSINE SYNTHASE 1; 1.
DR PANTHER; PTHR48066:SF1; CARNOSINE SYNTHASE 1; 1.
DR Pfam; PF18130; ATPgrasp_N; 1.
DR Pfam; PF15632; ATPgrasp_Ter; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 586..790
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 897 AA; 96036 MW; E76A2FCB07ED209B CRC64;
MLSLDPSGPE WDCPLGSKDL EEEGPWGGGS GLPPTGCFPG SWRQDVGLDC KGSPEGAEAR
AWSVYYYSLL QSCLQQAGLP ETQDRSQVPR TGCPGAEVTL CVLGSPSTFL PVLLEGGVQS
PGNMLLCLSP AWLMKVPAPG QPGEAALLVS KAVSFHPGGL TFLDDFVPPR RATYFLAXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XQLLAQQGGV AVPETLPPGL LRGGDASPGL
RLMELSGKEG QETLVKEEVE AFLRSEALGD ILQVAVKLSG WRWRGRQALR LHPRVELGAV
VDTVLALLEK LEEEESVLVE AVYPPVQLPC SDGLSPGPGL AVRICAVVCR TQGDRPLLSK
VVCGVGRGDR PLRHHNSLPR TLEVAALAAV LALEAGVDFA LTAAGGVLTP VALELNGGLC
LEACGALEGL WAAPRLGPAA DDAAAAPLVE TMLRRSARCL MEGKQLLVVG AGGVSKKFVW
EAARDYGLQL HLVESDPNHF ASQLVQTFIH FDMTEHRRDE ENARLLAELV RARGLKLDGC
FSYWDDCLVL TALLCQELGL PCSSPAAMRL AKQKSLTQLH LLRHHGPPWP APSLHAVPCC
PLESEADVER AVHQVPLPGV MKLEFGAGAV GVRLVEDVPQ CHEHFSRITR DLQGEADHPG
IGLGWGNAML LMEFVEGTEH DVDLVLFGGR LLAAFVSDNG PTRLPGFTET AACMPTGLAP
EQEAQMVQAA FRCCLGCGLL DGVFNVELKL TGAGPRLIEI NPRMGGFYLR DWILELYGVD
LLLAAVMVAC GLRPALPTHP RARGHLVGVM CLVSQHLQAL SSTASRETLQ ALHDRGLLRL
NLLEEALVPG EYEEPYCSVA CAGPSPTEAR LRLLGLCQGL GIDGPSYPVA HFLSHFK
//
