ID A0A2I3HN36_NOMLE Unreviewed; 1967 AA.
AC A0A2I3HN36;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Myosin XVIIIA {ECO:0000313|Ensembl:ENSNLEP00000045058.1};
GN Name=MYO18A {ECO:0000313|Ensembl:ENSNLEP00000045058.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000045058.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000045058.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000045058.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; ADFV01099473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01099474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01099475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01099476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01099477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01099478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01099479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01099480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000048084.1; ENSNLEP00000045058.1; ENSNLEG00000003253.2.
DR GeneTree; ENSGT00940000155768; -.
DR Proteomes; UP000001073; Chromosome 19.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008094; F:ATP-dependent activity, acting on DNA; IEA:InterPro.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006259; P:DNA metabolic process; IEA:InterPro.
DR CDD; cd01386; MYSc_Myo18; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR036064; MYSc_Myo18.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR020587; RecA_monomer-monomer_interface.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF13; UNCONVENTIONAL MYOSIN-XVIIIA; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00595; PDZ; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50163; RECA_3; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 220..311
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 349..401
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 405..1184
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 542..607
FT /note="RecA family profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50163"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1454..1479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1780..1829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1867..1967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1248..1352
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1673..1714
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 140..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..338
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1867..1889
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1912..1927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1929..1944
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1945..1967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 498..505
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1967 AA; 222400 MW; EF642FB9DB200FEC CRC64;
MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS LRRGFFNLNR SSKRESKTRL
EISNPIPIKV ASGSDLHLTD IDSDSNRGSV ILDSGHLSTA SSSDDLKGEE GSFRGSVLQR
AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA SETSTPSEHS AAPSPQVEVR TLEGQLVQHP
GPGIPRPGHR SRAPELVTKK FPVDLRLPPV VPLPPPALRE LELQRRPTGD FGFSLRRTTM
LDRGPEGQAY RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GHNVESKSRD EIVEMIRQSG
DSVRLKVQPI PELSELSRSW LRSGEGPRRE PSDAKTEEQI AAEEAWNETE KVWLVHRDGF
SLASQLKSEE LNLPEGKVRV KLDHDGAILD VDEDDVEKAN APSCDRLEDL ASLVYLNESS
VLHTLRQRYG ASLLHTYAGP SLLVLGPRGA PAVYSEKVMH MFKGCRREDM APHIYAVAQT
AYRAMLMSRQ DQSIILLGSS GSGKTTSCQH LVQYLATIAG ISGNKVFSVE KWQALYTLLE
AFGNSPTIMN GNATRFSQIL SLDFDQAGQV ASASIQTMLL EKLRVARRPA SEATFNVFYY
LLACGDGTLR TELHLNHLAE NMCLGLCGLS PQPEENHNAS QQFNKLQAAM KVLGISPDEQ
KACWLILAAI YHLGAAGATK AGRKQFARHE WAQKAAYLLG CSLEELSSAI FKHQHKGGTL
QRSTSFRQGP EESGLGDGTG PKLSALECLE GMAAGLYSEL FTLLVSLVNR ALKSSQHSLC
SMMIVDTPGF QNPEQGGSAR GASFEELCHN YTQDRLQRLF HERTFVQELE RYKEENIELA
FDDLEPPTDD SVAAVDQASH QSLVRSLART DEARGLLWLL EEEALVPGAS EDALLERLFS
YYGPQEGDKK GQSPLLHSSK PHHFLLGHSH GTNWVEYNVT GWLNYTKQNP ATQNAPRLLQ
DSQKKIISNL FVGRAGSATV LSGSIAGLEG GSQLALRRVT SMRKSFATGM AAVKKKSLCI
QMKLQVDALI DTIKKSKLHF VHCFLPVAEG WAGEPRSAAS RRVSSSSELD LPSGDHCEAG
LLQLDVPLLR TQLRGSRLLD AMRMYRQGYP DHMVFSEFRR RFDVLAPHLT KKHGRNYIVV
DERRVASVTS VIVSLDCALP PACAGLSSVF FRAGTLARLE EQRDEQTSRN LTLFQAACRG
YLARQHFKKR KIQDLAIRCV QKNIKKNKGV KDWPWWKLFT TVRPLIEVQL SEEQIRNKDE
EIQQLRSKLE KVEKERNELR LNNDRLESRI SELTSELTDE RNTGESASQL LDAETAERLR
AEKEMKELQT QYDALKKQME VMEMEVMEAR LIRAAEINGE VDDDDAGGEW RLKYERAVRE
VDFTKKRLQQ EFEDKLEVEQ QNKRQLERRL GDLQADSEES QRALQQLKKK CQRLTAELQD
TKLHLEGQQV RNHELEKKQR RFDSELSQAH EEAQREKLQR EKLQREKDML LAEAFSLKQQ
LEEKDMDIAG FTQKVVSLEA ELQDISSQES KDEASLAKVK KQLRDLEAKV KDQEEELDEQ
AGTIQMLEQL KQMEVQLEEE YEDKQKVLRE KRELEGKLAT LSDQVNRRDF ESEKRLRKDL
KRTKALLADA QLMLDHLKNS APSKREIAQL KNQLEESEFT CAAAVKARKA MEIDDIAKAK
TALEEQLSRL QREKNEIQNR LEEDQEDMNE LMKKHKLLWL STPARSPLQS QVEFLEQSMV
DKSMVSRQEV KIRELETRLE FERTQVKRLE SLASRLKENM EKLTEERDQR IAAENREKEH
NKRLQRQLRD TKEEMGELAR KEAEASRKKH ELEMDLESLE AANQSLQADL KLAFKRIGDL
QAAIEDEMES DENEDLINSE GDSDVDSELE DRVDGVKSWL SKNKGPSKAA SDDGSLKSSS
PTSYWKSLAP DRSDDEHDPL DNTSRPRYSH SYLSDSDTEA KLTETSA
//
