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Database: UniProt
Entry: A0A2I3HPI8_NOMLE
LinkDB: A0A2I3HPI8_NOMLE
Original site: A0A2I3HPI8_NOMLE 
ID   A0A2I3HPI8_NOMLE        Unreviewed;       548 AA.
AC   A0A2I3HPI8;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=Hepatocyte nuclear factor 1-beta {ECO:0000256|ARBA:ARBA00039291};
DE   AltName: Full=Transcription factor 2 {ECO:0000256|ARBA:ARBA00041233};
GN   Name=HNF1B {ECO:0000313|Ensembl:ENSNLEP00000045452.1};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000045452.1, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000045452.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000045452.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the HNF1 homeobox family.
CC       {ECO:0000256|ARBA:ARBA00009966}.
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DR   AlphaFoldDB; A0A2I3HPI8; -.
DR   Ensembl; ENSNLET00000059073.1; ENSNLEP00000045452.1; ENSNLEG00000002919.3.
DR   GeneTree; ENSGT00940000153818; -.
DR   Proteomes; UP000001073; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProt.
DR   GO; GO:0030073; P:insulin secretion; IEA:InterPro.
DR   GO; GO:0001889; P:liver development; IEA:InterPro.
DR   GO; GO:0031016; P:pancreas development; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR   InterPro; IPR039066; HNF-1.
DR   InterPro; IPR006899; HNF-1_N.
DR   InterPro; IPR044869; HNF-1_POU.
DR   InterPro; IPR023219; HNF1_dimer_N_dom_sf.
DR   InterPro; IPR006897; HNF1b_C.
DR   InterPro; IPR044866; HNF_P1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   PANTHER; PTHR11568; HEPATOCYTE NUCLEAR FACTOR 1; 1.
DR   PANTHER; PTHR11568:SF2; HEPATOCYTE NUCLEAR FACTOR 1-BETA; 1.
DR   Pfam; PF04814; HNF-1_N; 1.
DR   Pfam; PF04812; HNF-1B_C; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF100957; Dimerization cofactor of HNF-1 alpha; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR   PROSITE; PS51937; HNF_P1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS51936; POU_4; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          1..32
FT                   /note="HNF-p1"
FT                   /evidence="ECO:0000259|PROSITE:PS51937"
FT   DOMAIN          93..188
FT                   /note="POU-specific atypical"
FT                   /evidence="ECO:0000259|PROSITE:PS51936"
FT   DOMAIN          229..310
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        231..311
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          64..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          324..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   548 AA;  60186 MW;  144CE7A096FF6710 CRC64;
     MVSKLTSLQQ ELLSALLSSG VTKEVLIQAL EELLPSPNFG VKLETLPLSP GSGAEPDTKP
     VFHTLTNGHA KGRLSGDEGS EDGDDYDTPP ILKELQALNT EEAAEQRAEV DRMLSEDPWR
     AAKMIKGYMQ QHNIPQREVV DVTGLNQSHL SQHLNKGTPM KTQKRAALYT WYVRKQREIL
     RQFNQTVQSS GNMTDKSSQD QLLFLFPEFS QQSQGPGQSD DACSEPTNKK MRRNRFKWGP
     ASQQILYQAY DRQKNPSKEE REALVEECNR AECLQRGVSP SKAHGLGSNL VTEVRVYNWF
     ANRRKEEAFR QKLAMDAYSS NQTHSLNPLL SHSSPHHQPS SSPPNKLSGV RYSQQGNNEV
     TSSSTISHHG NSAMVTSQSV LQQVSPASLD PGHNLLSPDG KMISVSGGGL PPVSTLTNIH
     SLSHHNPQQS QNLIMTPLSG VMAIAQSLNT SQAQSVPVIN SVAGSLAALQ PVQFSQQLHS
     PHQQPLMQQS PGGHMAQQPF MAAVTQLQNS HMSSTSLVMP THHLLCVQQQ GPCFPHHHPL
     GSCHGKAQ
//
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