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Database: UniProt
Entry: A0A2I3HS58_NOMLE
LinkDB: A0A2I3HS58_NOMLE
Original site: A0A2I3HS58_NOMLE 
ID   A0A2I3HS58_NOMLE        Unreviewed;       727 AA.
AC   A0A2I3HS58;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-JUN-2019, entry version 10.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000046321};
GN   Name=ADAM22 {ECO:0000313|Ensembl:ENSNLEP00000046321};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000046321, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000046321, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000046321}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
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DR   EMBL; ADFV01000680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01000681; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01000682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01000683; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01000684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01000685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01000686; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01000687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01000688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01000689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSNLET00000039757; ENSNLEP00000046321; ENSNLEG00000015048.
DR   GeneTree; ENSGT00940000156889; -.
DR   Proteomes; UP000001073; Chromosome 11.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR013111; EGF_extracell.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR034027; Reprolysin_adamalysin.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF07974; EGF_2; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   PRINTS; PR00289; DISINTEGRIN.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; SSF57552; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS00022; EGF_1; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00068,
KW   ECO:0000256|SAAS:SAAS00429857};
KW   Membrane {ECO:0000256|SAAS:SAAS01078504, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Transmembrane {ECO:0000256|SAAS:SAAS01078486,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS01078482,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    600    623       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      102    301       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN      307    394       Disintegrin. {ECO:0000259|PROSITE:
FT                                PS50214}.
FT   REGION      642    727       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2I3HS58}.
FT   COMPBIAS    645    669       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A2I3HS58}.
FT   DISULFID    366    386       {ECO:0000256|PROSITE-ProRule:PRU00068}.
SQ   SEQUENCE   727 AA;  81005 MW;  9907B8784FDDE186 CRC64;
     MILFWDESRW PCLIFFFVVG SGMFYDGNHT YLIEPEENDT TQEDFHFHSV YKSRLFEFSL
     DDLPSEFQQV NITPPKFILK PRPKRSKRQL RRYPRNVEEE TKYIELMIVN DHLMFKKHRL
     SVVHTNTYAK SVVNMADVIY KDQLKTRIVL VAMETWATDN KFAISENPLI TLREFMKYRR
     DFIKEKSDAV HLFSGSQFES SRSGAAYIGG ICSLLKGGGV NEFGKTDLMA VTLAQSLAHN
     IGIISDKRKL ASGECKCEDT WSGCIMGDTG YYLPKKFTQC NIEEYHDFLN SGGGACLFNK
     PSKLLDPPEC GNGFIETGEE CDCGTPAECV LEGAECCKKC TLTQDSQCSD GLCCKKCKFQ
     PMGTVCREAV NDCDIRETCS GNSSQCAPNI HKMDGYSCDG VQGICFGGRC KTRDRQCKYI
     WGQKVTASDK YCYEKLNIEG TEKGNCGKDK DTWIQCNKRD VLCGYLLCTN IGNIPRLGEL
     DGEITSTLVV QQGRTLNCSG GHVKLEEDVD LGYVEDGTPC GPQMMCLEHR CLPVASFNFS
     TCLSSKEGTI CSGNGVCSNE LKCVCNRHWI GSDCNTYFPH NDDAKTGITL SGNGVAGTNI
     IIGIIAGTIL VLALILGITA WGYKQLPQGD YVKKPGDGDS FYSDIPPGVS TNSASSSKKR
     SNGLSHSWSE RIPDTKHISD ICENGRPRSN SWQGNLGGNK KKIRGKRFRP RSNSTEHLRN
     YAHTNVH
//
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