ID A0A2I3HSJ2_NOMLE Unreviewed; 498 AA.
AC A0A2I3HSJ2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=SHC-transforming protein 1 {ECO:0000256|ARBA:ARBA00020297};
DE AltName: Full=Src homology 2 domain-containing-transforming protein C1 {ECO:0000256|ARBA:ARBA00031530};
GN Name=LOC101176901 {ECO:0000313|Ensembl:ENSNLEP00000046563.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000046563.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000046563.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000046563.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; ADFV01072467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3HSJ2; -.
DR STRING; 61853.ENSNLEP00000046563; -.
DR Ensembl; ENSNLET00000052081.1; ENSNLEP00000046563.1; ENSNLEG00000031693.1.
DR GeneTree; ENSGT00950000182870; -.
DR InParanoid; A0A2I3HSJ2; -.
DR Proteomes; UP000001073; Chromosome X.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01209; PTB_Shc; 1.
DR CDD; cd09925; SH2_SHC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006019; PID_Shc-like.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035676; SHC_SH2.
DR PANTHER; PTHR10337; SHC TRANSFORMING PROTEIN; 1.
DR PANTHER; PTHR10337:SF2; SHC-TRANSFORMING PROTEIN 1; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00629; SHCPIDOMAIN.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 138..267
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 387..494
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 19..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 498 AA; 53456 MW; 825197DDEEF5FB45 CRC64;
MNLLPHKPKY NALRNESLSS LKEGPSGSTL PEELPSPSAS SLGPILPLLP RNPSPTTLNL
RLANRARGHL GPKGDPGRAA NDGEGIVGDM NKLSGGGGCR TQVEGGQLGG EEWTRHGSFV
NKPMWGWLHP SDKVMRPGVS YLVWYMGCVE VLQSMSALDF NTWTQVTREA ISLVCQGAGG
TGRRKPCSHP LSSILGRSNL KFAGMIITTA NIITNHHMQS ISFASSGDPD TAEYVTNIAK
DPVNQKACHI LECPQGLAQD VISTTGQKPP KLVTPYDRMT GFDGLAWDEE EGEPPGHQLR
EGAAPGAARP TPPSAQTPSH LGATLPLGQS VGGDPEVCKQ MPPPPPCLAR ELFDDPSNVN
MQNLDKSWQA GGGAGTPNPA INGSTPWDLF DMKPFEDALH MPPPPQLVSM REAEALLQLN
GDFLVQESMT TPGQYVLTGL QSGDPKHLLL VDPEGVVRTK DHRFESVSHL ISYHMDNHLP
IISAGSELCL QQPVEQKL
//
