ID A0A2I3HSY9_NOMLE Unreviewed; 903 AA.
AC A0A2I3HSY9;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=FYVE, RhoGEF and PH domain containing 4 {ECO:0000313|Ensembl:ENSNLEP00000046596.1};
GN Name=FGD4 {ECO:0000313|Ensembl:ENSNLEP00000046596.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000046596.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000046596.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000046596.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; ADFV01103424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01103425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01103426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01103427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01103428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01103429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01103430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01103431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01103432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01103433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3HSY9; -.
DR STRING; 61853.ENSNLEP00000046596; -.
DR Ensembl; ENSNLET00000034475.1; ENSNLEP00000046596.1; ENSNLEG00000016556.2.
DR GeneTree; ENSGT00940000155765; -.
DR InParanoid; A0A2I3HSY9; -.
DR OMA; EREHSFY; -.
DR Proteomes; UP000001073; Chromosome 23.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15741; FYVE_FGD1_2_4; 1.
DR CDD; cd15791; PH1_FDG4; 1.
DR CDD; cd13236; PH2_FGD1-4; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR037742; FDG4_N_PH.
DR InterPro; IPR035941; FGD1-4_PH2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF98; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 343..530
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 559..658
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 696..756
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 780..877
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..903
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 903 AA; 100844 MW; F84A8BA8529901C3 CRC64;
MSGEGGSNFR RVAIRRKSNP SYLPPGVPRP WSRPASQLGR VGTAAFKGQV PSGATGSSTC
PKIALVPPCS TSSTTTLVGE NVSEEEAQGI NGNRPAKHSA ASPKPQVPPK PLHLQNSPSS
NIHQTPRHKA LPSAKPRMEE IKPASASCVS KEKPSKVSDL ISRFEGGSSL SNYNDLKKES
AVNLNAPKTP GRHGLTTTPQ QKLLSQHLPQ RQGNDTDKTQ GAQTCVANGV MAAQNQMECE
EEKAAALSPD TSIQASEPLL DTHVVNGERD ETATAPASPT TDSCDGNVSD SSYRTPGIGP
VLPLEERGAE TETNVQEREN GESPLELEQL DQHHEMKETN EQKLHKIANE LLLTERAYVN
RLDLLDQVFY CKLLEEANRG SFPAEMVNKI FSNISSINAF HSKFLLPELE KRMQEWETTP
RIGDILQKLA PFLKMYGEYV KGFDNAMELV KNMTERIPQF KSVVEEIQKQ KICGSLTLQH
HMLEPVQRIP RYEMLLKDYL RKLPPDSLDW NDAKKSLEII STAASHSNSA IRKMENLKKL
LEIYEMLGEE EDIVNPSNEL IKEGQILKLA ARNTSAQERY LFLFNNMLLY CVPRFSLVGS
KFTVRTRVGI DGMKIVETQN EEYPHTFQVS GKERTLELQA SSAQDKEEWI KALQETIDAF
HQRHETFRNA IAKDNDIHSE VSTAELGKRA PRWIRDNEVT MCMKCKEPFN ALTRRRHHCR
ACGYVVCWKC SDYKAQLEYD GGKLSKVCKD CYQIISGFTD SEEKKRKGIL EIESAEVSGN
SVVCSFLQYM EKSKPWQKAW CVIPKQDPLV LYMYGAPQDV RAQATIPLLG YVVDEVPKSA
DLPHSFKLTQ SKSVHSFAAD SEELKQKWLK VVLLAVTGET AGGPNEHPAT LDDHPEPKKK
SEC
//
