ID A0A2I3HTA1_NOMLE Unreviewed; 667 AA.
AC A0A2I3HTA1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Regulator of G-protein signaling 9 {ECO:0000256|ARBA:ARBA00034540};
GN Name=RGS9 {ECO:0000313|Ensembl:ENSNLEP00000046760.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000046760.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000046760.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000046760.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
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DR EMBL; ADFV01011204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01011205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01011206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01011207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01011208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01011209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01011210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01011211; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01011212; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01011213; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3HTA1; -.
DR Ensembl; ENSNLET00000041110.1; ENSNLEP00000046760.1; ENSNLEG00000014838.3.
DR GeneTree; ENSGT00940000156505; -.
DR Proteomes; UP000001073; Chromosome 19.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd04450; DEP_RGS7-like; 1.
DR CDD; cd00068; GGL; 1.
DR CDD; cd08739; RGS_RGS9; 1.
DR Gene3D; 1.10.1240.60; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR047016; RGS6/7/9/11.
DR InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR InterPro; IPR047077; RGS9_RGS.
DR InterPro; IPR040759; RGS_DHEX.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45746; LP21163P; 1.
DR PANTHER; PTHR45746:SF1; REGULATOR OF G-PROTEIN SIGNALING 9; 1.
DR Pfam; PF00631; G-gamma; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF18148; RGS_DHEX; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00049; DEP; 1.
DR SMART; SM01224; G_gamma; 1.
DR SMART; SM00224; GGL; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Vision {ECO:0000256|ARBA:ARBA00023305}.
FT DOMAIN 295..410
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT REGION 486..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 667 AA; 75866 MW; F9298A5D97D465B9 CRC64;
MALHNFQNCS RQSAFSCSVL QIEALVKDMQ NPETGVRMQN QRVLVTSVPH AMTVLAWNRP
HRSNTAQNLG NFIVRYGYIY PLQDPKNLIL KPDGSLYRFQ TPYFWPTQQW PAEDTDYAIY
LAKRNIKKKG ILEEYEKENY NFLNQKMNYK WDFVIMQAKE QYRAGKERNK ADRYALDCQE
KAYWLVHRCP PGMDNVLDYG LDRVTNPNEV KKQTVVAVKK EIMYYQQALT RSTVKSSVSL
GGIVKYSEQF SSNDAIMSGC LPSNPWITDD TQFWDLNAKL VEIPTKMRVE RWAFNFSELI
RDPKGRQSFQ YFLKKEFSGE NLGFWEACED LKYGDQSKVK EKAEEIYKLF LAPGARRWIN
IDGKTMDITV KGLKHPHRYV LDAAQTHIYM LMKKDSYARY LKSPIYKEML AKAIEPQETT
KKSSTLPFMR RHLRSSPSPV ILRQLEEEAK AREAANTVDI TQPGQHMAPS PHLTVYTGTC
VPPSPSSPFS SSCRSPRKPF ASPSRFIRRP SSTICPSPIR VALESSSGLE QKGECSGSMA
PRGPSVTESS EASLDTSWPR SRPRAPPKAR MALSFSRFLR RGCLASPVFA RLSPKCPAVS
HGRVQPLGDV GQQLPRLKSK RVANFFQIKM DVPTGSGTCL MDSEDAGTGE SGDRATEKEV
ICPWESL
//
