ID A0A2I3HTV4_NOMLE Unreviewed; 1426 AA.
AC A0A2I3HTV4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=A-kinase anchoring protein 13 {ECO:0000313|Ensembl:ENSNLEP00000047044.1};
GN Name=AKAP13 {ECO:0000313|Ensembl:ENSNLEP00000047044.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000047044.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000047044.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000047044.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; ADFV01044270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01044271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01044272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01044273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01044274; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01044275; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01044276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01044277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01044278; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01044279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000050899.1; ENSNLEP00000047044.1; ENSNLEG00000011353.2.
DR GeneTree; ENSGT00940000154146; -.
DR Proteomes; UP000001073; Chromosome 6.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20878; C1_AKAP13; 1.
DR CDD; cd13392; PH_AKAP13; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR13944:SF18; A-KINASE ANCHOR PROTEIN 13; 1.
DR PANTHER; PTHR13944; AGAP007712-PA; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 421..468
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 616..803
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 843..945
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 85..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1278..1426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 959..990
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 85..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1091..1114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1278..1302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1326..1345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1359..1386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1426 AA; 161021 MW; BACBED06E54763BB CRC64;
MIYIINRENW CTIEPCPDAA SLLASKQSPE CEDFLDVGLG RECTSKQGVL KRESGSDSDL
FHSPSDDMDS IIFTKPEEEQ LACDITGSSS STDDTASLDR HSSHGSDVSL SQILKPNRSR
DRQSLDGFYS HGMGAEGRES ESEPADPGDV EEEEMDSITE VPANCSVLRS SMRSLSPFRR
HSWGPGKNAA SDAEMNHRSS MRVLGDVVRR PPIHRRSFSL EGLTGGAGIG NKPSSSLEVS
SANAKELRHP FSGEERIDSL VSLSEEDLES GQREHRMFDQ QICHRPKQQG FNYCTSAISS
PLTKSISLMT ISHPGLDTIQ QPSSTFYSAS LLFNFCSPLK KSIFLFLFSI TEENYSLLPH
SFSKKDSEWK SGTKVSRTFS YIKNKMSSSK KSKEKEKEKD KIKEKEKDSK DKEKDKKTVN
GHTFSSIPVV GPISCSQCMK PFTNKDAYTC ANCSAFVHKG CRESLASCAK VKMKQPKGSL
QAHDTSSLPT VIMRNKPSQP KERPRSAVLL VDETTATPIF ANRRSHVSIQ NIAGVGNDEN
MSNTWKFLSH STDSLNKISK VNESTESLTD EGVGTDMNEG QLLGDFEIDS KQLEAESWSR
IIDTKFLKQQ KKDVVKRQEV IYELMQTELH HVRTLKIMSD VYSRGMMTDL LFEQQMVEKL
FPCLDELISI HSQFFQRILD EKNFLIKRIG DVLVNQFSGE NAERLKKTYG KFCGQHNQSV
NYFKDLYAKD KRFQAFVKKK MSSSLVRRLG IPECILLVTQ RITKYPVLFQ RILQCTKDNE
VEQEDLAQSL SLVKDVIGAV DSEVASYEKK VRLNEIYTKT DSKSIMRMKS GQMFAKEDLK
RKKLVRDGSV FLKNAAGRLK EVQAVLLTDI LVFLQEKDQK YIFASLDQKS TVISLKKLIV
REVAHEEKGL FLISMGMKDP EMVEVHASSK EERNSWIQII QDTINTLNRD EDEGIPSENE
EEKKMLDTKA RELKEQLQQK DQQILLLLEE KEMIFRDMAE CSTPLPEDCS PTHSPRVLFR
SNTEEALKGG PLMKSAINEV EILQGLVSGN LGGTLGPTVS SPIEQEGVVG PVSLPRRAET
FGGFDSHQMN ASKGGEKEEG DDGQDLRRTE SDSGLKKGGN ANLVFMLKRN SEQVVHSVVH
LHELLSTLQG VVLQQDSYIE DQKLVLSERA LTRSLSRPSS LIEQEKQRSL EKQRQDLANL
QKQQAQYLEE KRRREREWEA RERELREREA LLAQREEKVQ QGQQDLEKER EELQQKKGTY
QYDLERLRAA QKQLEREQEQ LRREAERLSQ RQTERDLCQV SHPHTKLMRI PSFFPSPEEP
HSPSAPSIAK SGSLDSELSV SPKRNSISRT HKDKGPFHIL SSTIQTNKGP EGQSQAPAST
SASARLFGLT KPKEKKEKKK KNKTSRSQPG DGPMSEVSAE GEEIFC
//
