ID A0A2I3HUR6_NOMLE Unreviewed; 1293 AA.
AC A0A2I3HUR6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Cytoplasmic linker associated protein 2 {ECO:0000313|Ensembl:ENSNLEP00000047221.1};
GN Name=CLASP2 {ECO:0000313|Ensembl:ENSNLEP00000047221.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000047221.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000047221.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000047221.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01172098; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172100; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000053236.1; ENSNLEP00000047221.1; ENSNLEG00000004683.3.
DR GeneTree; ENSGT00940000155574; -.
DR Proteomes; UP000001073; Chromosome 4.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:UniProt.
DR GO; GO:0008017; F:microtubule binding; IEA:UniProt.
DR GO; GO:0051494; P:negative regulation of cytoskeleton organization; IEA:UniProt.
DR GO; GO:1902904; P:negative regulation of supramolecular fiber organization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF9; CLIP-ASSOCIATING PROTEIN; 1.
DR Pfam; PF21040; CEP104-like_TOG; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR SMART; SM01349; TOG; 3.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 84..317
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 647..884
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1050..1286
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 877..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 951..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..645
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 957..972
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1293 AA; 140879 MW; 366A7858296E0FAE CRC64;
MAMGDDKSFD DEESVDGNRP SSAASAFKVP APKTSGNPAN SARKPGSAGG PKVGGASKEG
GAGAVDEDDF IKAFTDVPSI QIYSSRELEE TLNKIREILS DDKHDWDQRA NALKKIRSLL
VAGAAQYDCF FQHLRLLDGA LKLSAKDLRS QVVREACITV AHLSTVLGNK FDHGAEAIVP
TLFNLVPNSA KVMATSGCAA IRFIIRHTHV PRLIPLITSN CTSKSVPVRR RSFEFLDLLL
QEWQTHSLER HAAVLVETIK KGIHDADAEA RVEARKTYMG LRNHFPGEAE TLYNSLEPSY
QKSLQTYLKS SGSVASLPQS DRSSSSSQES LNRAFSSKWS TANPSTVAGR VSAGSSKASS
LPGSLQRSRS DIDVNAAAGA KAHHAAGQSV RSGRLGAGAL NAGSYASLED TSDKLDGTAS
EDGRVRAKLS APLAGMGNAK TDSRGRSRTK MVSQSQPGSR SGSPGRVLTT TALSTVSSGV
QRVLVNSASA QKRSKIPRSQ GCSREASPSR LSVARSSRIP RPSVSQGCSR EASRESSRDT
SPVRSFQPLA SRHHSRSTGA LYAPDVYGAS GPGYGISQSS RLSSSVSAMR VLNTGSDVEE
AVADALKKPA RRRYESYGMH SDDDANSDAS SACSERSYSS RNGSIPTYMR QTEDVAEVLN
RCASSNWSER KEGLLGLQNL LKNQRTLSRV ELKRLCEIFT RMFADPHGKV FSMFLETLVD
FIQVHKDDLQ DWLFVLLTQL LKKMGADLLG SVQAKVQKAL DVTRESFPND LQFNILMRFT
VDQTQTPSLK VKVAILKYIE TLAKQMDPGD FINSSETRLA VSRVITWTTE PKSSDVRKAA
QSVLISLFEL NTPEFTMLLG ALPKTFQDGA TKLLHNHLRN TGNGTQSSMG SPLTRPTPRS
PANWSSPLTS PTNTSQNTLS PSAFDYDTEN MNSEDIYSSL RGVTEAIQNF SFRSQEDMNE
PLKRDSKKDD GDSICGGPGM SDPRAGGDAT DSSQTALDNK ASLLHSMPTH SSPRSRDYNP
YNYSDSISPF NKSALKEAMF DDDADQFPDD LSLDHSDLVA ELLKELSNHN ERVEERKIAL
YELMKLTQEE SFSVWDEHFK TILLLLLETL GDKEPTIRAL ALKVLREILR HQPARFKNYA
ELTVMKTLEA HKDPHKEVVR SAEEAASVLA TSISPEQCIK VLCPIIQTAD YPINLAAIKM
QTKVIERVSK ETLNLLLPEI MPGLIQGYDN SESSVRKACV FCLVAVHAVI GDELKPHLSQ
LTGSKMKLLN LYIKRAQTGS GGADPTTDVS GQS
//
