ID A0A2I3HV23_NOMLE Unreviewed; 566 AA.
AC A0A2I3HV23;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit beta-2 {ECO:0000256|ARBA:ARBA00019005};
DE AltName: Full=Calcium channel voltage-dependent subunit beta 2 {ECO:0000256|ARBA:ARBA00030521};
GN Name=CACNB2 {ECO:0000313|Ensembl:ENSNLEP00000047395.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000047395.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000047395.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000047395.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004278}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004278}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004278}.
CC -!- SIMILARITY: Belongs to the calcium channel beta subunit family.
CC {ECO:0000256|ARBA:ARBA00010836}.
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DR EMBL; ADFV01176411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01176412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01176413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01176414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01176415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01176416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01176417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01176418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01176419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01176420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3HV23; -.
DR Ensembl; ENSNLET00000053423.1; ENSNLEP00000047395.1; ENSNLEG00000012660.3.
DR GeneTree; ENSGT00950000182837; -.
DR Proteomes; UP000001073; Chromosome 9.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR CDD; cd12040; SH3_CACNB2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035605; CACNB2_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR005444; VDCC_L_b2su.
DR InterPro; IPR000584; VDCC_L_bsu.
DR PANTHER; PTHR11824; VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT; 1.
DR PANTHER; PTHR11824:SF9; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR PRINTS; PR01626; LCACHANNELB.
DR PRINTS; PR01628; LCACHANNELB2.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT DOMAIN 31..100
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 107..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..547
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 63630 MW; F1551A624D8933A8 CRC64;
VQEFKTTGRG GGRLKPRSCH CSPAWATRTK PVAFAVRTNV SYSAAHEDDV PVPGMAISFE
AKDFLHVKEK FNNDWWIGRL VKEGCEIGFI PSPVKLENMR LQHEQRAKQG KFYSRGNSSS
SLGDIVPSSR KSTPPSSAID IDATGLDAEE NDIPANHRSP KPSANSVTSP HSKEKRMPFF
KKEQHSSGND GGTFPWGPVV LVTDMMQKAL FDFLKHRFEG RISITRVTAD ISLAKRSVLN
NPSKHAIIER SNTRSSLAEV QSEIERIFEL ARTLQLVVLD ADTINHPAQL SKTSLAPIIV
YVKISSPKVL QRLIKSRGKS QAKHLNVQMV AADKLAQCPP ELFDVILDEN QLEDACEHLA
DYLEAYWKAT HPPSSSLPNP LLSRTLATSS LPLSPTLASN SQGSQGDQRT DRSAPIRSAS
QAEEEPSVEP VKKSQHRSSS SAPHHNHRSG TSRGLSRQET FDSETQESRD SAYVEPKEDY
SHDHVDHYAS HRDHNHRDET HGSSDHRHRE SRHRSRDVDR EQDHNECNKQ RSRHKSKDRY
CEKDGEVISK KRNEAGEWNR DVYIRQ
//
