ID A0A2I3HWN4_NOMLE Unreviewed; 157 AA.
AC A0A2I3HWN4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Interleukin-1 {ECO:0000256|RuleBase:RU003753};
GN Name=IL1RN {ECO:0000313|Ensembl:ENSNLEP00000047932.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000047932.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000047932.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000047932.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Anti-inflammatory antagonist of interleukin-1 family of
CC proinflammatory cytokines such as interleukin-1beta/IL1B and
CC interleukin-1alpha/IL1A. Protects from immune dysregulation and
CC uncontrolled systemic inflammation triggered by IL1 for a range of
CC innate stimulatory agents such as pathogens.
CC {ECO:0000256|ARBA:ARBA00034096}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU003753}.
CC -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000256|ARBA:ARBA00010448,
CC ECO:0000256|RuleBase:RU003753}.
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DR EMBL; ADFV01102548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3HWN4; -.
DR Ensembl; ENSNLET00000057847.1; ENSNLEP00000047932.1; ENSNLEG00000002015.3.
DR GeneTree; ENSGT00950000182943; -.
DR Proteomes; UP000001073; Chromosome 14.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005149; F:interleukin-1 receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR CDD; cd00100; IL1; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR020877; IL-1_CS.
DR InterPro; IPR000975; IL-1_fam.
DR InterPro; IPR003297; IL-1RA/IL-36.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR10078; INTERLEUKIN-1 FAMILY MEMBER; 1.
DR PANTHER; PTHR10078:SF28; INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN; 1.
DR Pfam; PF00340; IL1; 1.
DR PRINTS; PR00264; INTERLEUKIN1.
DR PRINTS; PR01360; INTRLEUKIN1X.
DR SMART; SM00125; IL1; 1.
DR SUPFAM; SSF50353; Cytokine; 1.
DR PROSITE; PS00253; INTERLEUKIN_1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Secreted {ECO:0000256|RuleBase:RU003753};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
SQ SEQUENCE 157 AA; 17689 MW; CCABDC380E1AD0ED CRC64;
MATVCRPFGR KSSKMQAFRI WDVNQKTFYL RNNQLVAGYL QGPNVNLEEK IDVVPIKPHA
LFLGIHGGKM CLSCVKSGDE TRLQLEAVNI TDLSENRKQD KRFTFIRSDS GPTTSFESAA
CPGWFLCTAM EADQPVSLTN MPDEGVVVTK FYFQEDE
//
