ID A0A2I3HYG8_NOMLE Unreviewed; 547 AA.
AC A0A2I3HYG8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Adenosine deaminase domain containing 1 {ECO:0000313|Ensembl:ENSNLEP00000048653.1};
GN Name=ADAD1 {ECO:0000313|Ensembl:ENSNLEP00000048653.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000048653.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000048653.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000048653.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01065157; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01065158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01065159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01065160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01065161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01065162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3HYG8; -.
DR Ensembl; ENSNLET00000045645.1; ENSNLEP00000048653.1; ENSNLEG00000009415.2.
DR GeneTree; ENSGT00940000156842; -.
DR Proteomes; UP000001073; Chromosome 7b.
DR GO; GO:0004000; F:adenosine deaminase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd19905; DSRM_ADAD1; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR InterPro; IPR002466; A_deamin.
DR InterPro; IPR044455; ADAD1_DSRM.
DR InterPro; IPR014720; dsRBD_dom.
DR PANTHER; PTHR10910:SF103; ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR10910; EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN; 1.
DR Pfam; PF02137; A_deamin; 1.
DR Pfam; PF00035; dsrm; 1.
DR SMART; SM00552; ADEAMc; 1.
DR SMART; SM00358; DSRM; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR PROSITE; PS50137; DS_RBD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 96..164
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 249..542
FT /note="A to I editase"
FT /evidence="ECO:0000259|PROSITE:PS50141"
SQ SEQUENCE 547 AA; 60842 MW; 36F19825DE9A8DC5 CRC64;
MASNNHWFQS SQVPSFAQML KKNLPVQPAT KTITTPTGCS SESYSLSKMA SKVTQVTGNF
PEPLLSKSLS SISNPVLPPK KIPKEFIMKY KRGEINPVSA LHQFAQMQRV QLDLKETVTT
GNVMGPYFAF CAVVDGIQYK TGLGQNKKES RSNAAKLALD ELLQLDEPEP RILETSGPPP
FPAEPVVLPE PAYVSKVHYE GRHIQYAKIS QIVKETFDQL ISNRSEYLKY SSSLAAFIIE
RAGQHEVVAI GTGEYNYSQD IKPNGRVLHD THAVVTARRS LLRYFYRQLL LFYSKNPAMM
EKSIFCTEPT SNLLTLKQNI NICLYMNQLP KGSAQIKSQL RLNPHSISAF EANEELCLHV
AVEGKIYLTV YCPKDGVNRI SSMSSSDKLT RWEVLGVQGA LLSHFIQPVY ISSILVGDGN
CSDTRGLEIA IKQRVDDALT SKLPMFYLVN RPHISLVPSA YPLQMNLEYK FLSLNWAQGD
VSLEIVDGLS GKITESSPFK SGMSMASRLC KAAMLSRFNL LAKEAKKELL EAGTYHAAKV
TSDLNLI
//
