ID A0A2I3HZL7_NOMLE Unreviewed; 3911 AA.
AC A0A2I3HZL7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Ankyrin 2 {ECO:0000313|Ensembl:ENSNLEP00000048947.1};
GN Name=ANK2 {ECO:0000313|Ensembl:ENSNLEP00000048947.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000048947.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000048947.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000048947.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; ADFV01049623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049628; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000049758.1; ENSNLEP00000048947.1; ENSNLEG00000016262.2.
DR GeneTree; ENSGT00940000155279; -.
DR Proteomes; UP000001073; Chromosome 18.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08804; Death_ank2; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF49; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 3.
DR Pfam; PF12796; Ank_2; 5.
DR Pfam; PF13637; Ank_4; 3.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 20.
DR PROSITE; PS50088; ANK_REPEAT; 20.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 45..77
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 78..110
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 111..143
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 214..246
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 247..279
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 280..312
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 313..345
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 346..378
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 379..411
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 412..444
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 445..477
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 478..510
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 511..543
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 544..576
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 577..609
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 610..642
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 643..675
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 676..708
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 709..741
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 742..774
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 950..1114
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1116..1262
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 3517..3601
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1617..2083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2145..2278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2303..2359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2378..2432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2456..2534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2552..2854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2869..2900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2935..2959
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3020..3047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3084..3410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3680..3711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3725..3806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1617..1631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1658..1685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1712..1750
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1765..1804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1812..1851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1917..1931
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1954..1987
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1988..2003
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2018..2073
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2203..2234
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2247..2263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2304..2327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2468..2506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2513..2534
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2552..2571
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2596..2617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2642..2669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2670..2720
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2731..2746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2762..2783
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2787..2802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2836..2854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2874..2900
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3125..3140
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3144..3164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3171..3215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3241..3255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3284..3300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3308..3338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3353..3382
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3390..3406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3725..3748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3757..3775
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3777..3791
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3911 AA; 428580 MW; 4A07B00B5A8A16E2 CRC64;
GHKFNTMNGN SDSNASFLRA ARAGNLDKVV EYLKGGIDIN TCNQNGLNAL HLAAKEGHVG
LVQELLGRGS SVDSATKKGN TALHIASLAG QAEVVKVLVK EGANINAQSQ NGFTPLYMAA
QENHIDVVKY LLENGANQST ATEDGFTPLA VALQQGHNQA VAILLENDTK GKVRLPALHI
AARKDDTKSA ALLLQNDHNA DVQSKMMVNR TTESGFTPLH IAAHYGNVNV ATLLLNRGAA
VDFTARNGIT PLHVASKRGN TNMVKLLLDR GGQIDAKTRD GLTPLHCAAR SGHDQVVELL
LERGAPLLAR TKNGLSPLHM AAQGDHVECV KHLLQHKAPV DDVTLDYLTA LHVAAHCGHY
RVTKLLLDKR ANPNARALNG FTPLHIACKK NRIKVMELLV KYGASIQAIT ESGLTPIHVA
AFMGHLNIVL LLLQNGASPD VTNIRGETAL HMAARAGQVE VVRCLLRNGA LVDARAREEQ
TPLHIASRLG KTEIVQLLLQ HMAHPDAATT NGYTPLHISA REGQVDVASV LLEAGAAHSL
ATKKGFTPLH VAAKYGSLDV AKLLLQRRAA ADSAGKNGLT PLHVAAHYDN QKVALLLLEK
GASPHATAKN GYTPLHIAAK KNQMQIASTL LNYGAETNIV TKQGVTPLHL ASQEGHTDMV
TLLLDKGANI HMSTKSGLTS LHLAAQEDKV NVADILTKHG ADQDAHTKLG YTPLIVACHY
GNVKMVNFLL KQGANVNAKT KNGYTPLHQA AQQGHTHIIN VLLQHGAKPN ATTANGNTAL
AIAKRLGYIS VVDTLKVVTE EVTTTTTTIT EKHKLNVPET MTEVLDVSDE EGDDTMTGDG
GEYLRPEDLK ELGDDSLPSS QFLDGMNYLR YSLEGGRSDS LRSFSSDRSH TLSHASYLRD
SAVMDDSVVI PSHQVSTLAK EAERNSYRLS WGTENLDNVA LSSSPIHSGF LVSFMVDARG
GAMRGCRHNG LRIIIPPRKC TAPTRVTCRL VKRHRLATMP PMVEGEGLAS RLIEVGPSAC
VRYMKSLGWN GKRPVIVEIP HFAALRGKER ELVVLRSENG DSWKEHFCDY TEDELNEILN
GMDEVLDSPE DLEKKRICRI ITRDFPQYFA VVSRIKQDSN LIGPEGGVLS STVVPQVQAV
FPEGALTKRI RVGLQAQPMH SELVKKILGN KATFSPIVTL EPRRRKFHKP ITMTIPVPKA
SSDVMLNGFG GDAPTLRLLC SITGGTTPAQ WEDITGTTPL TFVNECVSFT TNVSARFWLI
DCRQIQESVT FASQVYREII CVPYMAKFVV FAKSHDPIEA RLRCFCMTDD KVDKTLEQQE
NFAEVARSRD VEVLEGKPIY VDCFGNLVPL TKSGQHHIFS FFAFKENRLP LFVKVRDTTQ
EPCGRLSFMK EPKSTRGLVH QAICNLNITL PIYTKESESD QEQEEETEST ETSVLKSHLV
NEVPVLASPD LLSEVSEMKQ DLIKMTAILT TDVSDKAGSI KVKELVKAAE EEPGEPFEIV
ERVKEDLEKV NEILRSGTCT RDESSVQSSR SERGLVEEEW VIVSDEEIEE ARQKAPLEIT
EYPCVEVRID KEMKGKVEKD STGLVNYLTD DLNSSVPLPK EQLQTVQDKA GKKCEALAVG
RSSEKEGKVI PPDETQSTQK QHKPSLGIKK PVRRKLKEKQ KQKEEGLQAS AEKAEIKKGS
SEESLDEDPG LAPEPLPTVK ATSPLIEETP IGSIKDKVKA LQKRVEDEQK GRSKLPIRVK
GKEDVPKKTT HRTPPAASPS LKSERHAPGS PSSKTERHSA LSSSAKTERH PPVSPSSKTE
KHSPVSPSAK MERHSPVSSS SKTEKHSPVS PSTKAERHSP LSSTKTERHP PVSPSGKTDK
RPPVSPSGRT EKHPPVSPGR TEKRLPVSPS GRTDKHQPVS TAGKTEKHLP VSPSGKTEKQ
PPVSPTSKTE RIEETMSVRE LMKAFQSGQD PSKHKTGLFE HKSAKQKQPQ EKGKVRVEKE
KGPILTQRET QKTENQTIKR GQRLPVTGTA ESKRGVRVSS IGVKKEDAAG GKEKILSHKI
PEPVQSAPEE ESHRESKVPK EKMADEQGDM DLQISPDRKT STDFSEVIKQ ELEDNDKYQQ
FRLSEETEKA QLHLDQVLTS PFNTTFPLDY MKDEFLPALS LQSGALDGSS ESLKNEGVAG
SPCGSLMEGT PQISSEESYK HEGLAETPET SPESLSFSPK KSEEQTGETK ESTKIETTTE
IHSEKEDPTT KDITGGSEER GATVTEDSET STESFQKEAT LGSPKDTSPK REDDCTGSCS
VALAKETPAG LTEEAACDAG QRTFGSSAHK TQTDSEAQES TATSDETKAL PLPEASVKTD
TGTESKPQGV IRSPQGLELA LPSRDSEVLS AVADDSLAVS HKDSLEASPV LEDNSSHKTP
DSLEPSPLKE SPCRDSLESS PVEPKMKAGI FPSHFPLPAA VAKTELLMEV ASVRSRLLRD
PDGSAEDDSL EQTSLMESSG KSPLSPDTPS SEEVSYEVTP KTTDVSTPKP AVIHECAEED
DSENGEKKRF TPEEEMFKMV TKIKMFDELE QEAKQKRDYK KEPKLEESSS SSDPDADCSV
DVDELKHAGS GENESAVPVL VTSESRKVSS SSESEPELAQ LKKGADSGLL PEPVIRVQPP
SPLPSSMDSN SSPEEVQFQP IVSKQYTFKM NEDTQEEPGK SEEEKDSESH LAEDSHAVST
EAADRSYDKL NRDTDQPKIC DGHGCEAMSP SSSAAPVSSG LQSPTGDDVD EQPVIYKESL
ALQGTHEKDT EGEELDVSRA ESPRADCPSE SFSSSSSLLH CSVSEGKELD EDISATSSIQ
KTEVTKTDET FENLPKDCPS QDSSITTQTD RFSMDVPVSD LAETDEIYDP QITSPYENVP
SQSFFSSEES KTQTDANHTT SFHSSEVYSV TVTSPVEDVV VASSSSGTIL SKESNFEGQN
IKMESQQEST SWEMQSDSVS SSFEPTVSAT TAVVGEQISK VIITKTDVDS DSWSEIREDD
EAFEARVKEE EQKIFGLMVD RQSQGTTPDT TPARTPTEEG TPTSEQNPFL FQEGKLFEMT
RSGAIDMTKR SYADESFHFF QIGQESREET LSEDVKEGAT GAEPLPLETS AESLALSESK
ETVDDEAELL PDDMSEEVEE IPASDAQLNS QMGISASTEA PTKEAVSVGT KDLPTVQTGD
ISPLSGVKQI SCPDSSEPAV QVQLDFSTLT RSVYSDRGDD SPDSSPEEQK SVIEIPTAPM
ENVPSTESKS KIPVRTMPIS TPAPPSAEYE SSLSEDFLSS VDEENKEDEA KPKSKLPVKV
PLHRVEQQLS DLDTSVQKTV APQGQDMTSI APDNRSKSES DASSLDSKTK CPVKTRSYTD
TETESRERAE ELELESEEGA TRPKILTSRL PVKSRSTTSS CRVGTSPTKE SKEHFFDLYR
NSIEFFEEIS DEASKLVDRL TQSEREQEIV SDDESSSALE VSVIENLPPV ETEHSVPEDI
FDTRPIWDES IETLIERIPD ENGHDHAEDP QDEQERIEER LAYIADHLGF SWTELARELD
FTEEQIHQIR IENPNSLQDQ SHALLKYWLE RDGKHATDTN LVECLTKINR MDIVHLMETN
TEPLQERISH SYAEIEQTIT LDHSEGFSVL QEELCTAQHK QKKEQAVSKE SETCDHPPIV
SEEDISVGYS TFQDGIPKTE GDSSATALFP QTHKEQVQQD FSGKMQDLPE ESSLEYQQAY
FVTTPGTEAS ETQKPTIVPS SPSKTPEEVS TPPEEERLYL QTPTSSEQGG SPIIQEPEET
SEHREESSPR KTSLVIVESA DHQPETCERL DEDAAFEKGD DMPEIPPETV TEEEYIDEHG
HTVVKKVTRK IIRRYVSSEG TEKEEIMVQG MPQEPVSIEE GDGYSKVIKR VVLKSDTEQS
EVRQPDSLKP I
//
